A Trial of BXCL701 and Pembrolizumab in Patients With Small Cell Neuroendocrine Prostate Cancer
Description
An open-label, multicenter, Phase 1b/2 study to determine the composite response rate of BXCL701 administered orally and daily, combined wit PEMBRO, in patients with Small Cell Neuroendocrine Prostate Cancer(SCNC). This study will also assess other efficacy parameters as well as the safety of the combined treatment. This study will consist of two (2) stages. Lead-in Stage, in which the safety and tolerability of the combination will be assessed and confirmed. And the Efficacy Stage, in which patients with SCNC will be treated with BXCL701 combined with PEMBRO.
Study Start Date
February, 12 2019
Estimated Completion Date
June 2022
Interventions
- Drug: Talabostat Mesylate plus Pembrolizumab
Study ID
BioXcel Therapeutics Inc -- BXCL701-201
Status
Oops!
Something went wrong with your request. An error message has been sent to our team to investigate.
Please go back and try your request again, or go back to the home page.
Error Details:
struct | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cause |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Detail | An exception occurred while invoking an event handler method from Application.cfc. The method name is: onRequest. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Message | Event handler exception. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RootCause |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
StackTrace | coldfusion.runtime.EventHandlerException: Event handler exception. at coldfusion.runtime.AppEventInvoker.onRequest(AppEventInvoker.java:309) at coldfusion.filter.ApplicationFilter.invoke(ApplicationFilter.java:470) at coldfusion.filter.RequestMonitorFilter.invoke(RequestMonitorFilter.java:42) at coldfusion.filter.MonitoringFilter.invoke(MonitoringFilter.java:40) at coldfusion.filter.PathFilter.invoke(PathFilter.java:153) at coldfusion.filter.ExceptionFilter.invoke(ExceptionFilter.java:94) at coldfusion.filter.BrowserDebugFilter.invoke(BrowserDebugFilter.java:78) at coldfusion.filter.ClientScopePersistenceFilter.invoke(ClientScopePersistenceFilter.java:28) at coldfusion.filter.BrowserFilter.invoke(BrowserFilter.java:38) at coldfusion.filter.NoCacheFilter.invoke(NoCacheFilter.java:58) at coldfusion.filter.GlobalsFilter.invoke(GlobalsFilter.java:38) at coldfusion.filter.DatasourceFilter.invoke(DatasourceFilter.java:22) at coldfusion.filter.CachingFilter.invoke(CachingFilter.java:62) at coldfusion.CfmServlet.service(CfmServlet.java:219) at coldfusion.bootstrap.BootstrapServlet.service(BootstrapServlet.java:89) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:303) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208) at coldfusion.monitor.event.MonitoringServletFilter.doFilter(MonitoringServletFilter.java:42) at coldfusion.bootstrap.BootstrapFilter.doFilter(BootstrapFilter.java:46) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208) at coldfusion.inspect.weinre.MobileDeviceDomInspectionFilter.doFilter(MobileDeviceDomInspectionFilter.java:57) at coldfusion.bootstrap.BootstrapFilter.doFilter(BootstrapFilter.java:46) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208) at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:219) at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:110) at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:494) at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:169) at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:104) at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:116) at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:458) at org.apache.coyote.ajp.AjpProcessor.process(AjpProcessor.java:196) at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:637) at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:316) at java.util.concurrent.ThreadPoolExecutor.runWorker(Unknown Source) at java.util.concurrent.ThreadPoolExecutor$Worker.run(Unknown Source) at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61) at java.lang.Thread.run(Unknown Source) Caused by: coldfusion.runtime.CFPage$InvalidDateException: Date value passed to date function DateDiff is unspecified or invalid. at coldfusion.runtime.CFPage.DateDiff(CFPage.java:1604) at cftrial2ddetails2ecfm1310202973.runPage(C:\inetpub\wwwroot\trial-details.cfm:187) at coldfusion.runtime.CfJspPage.invoke(CfJspPage.java:247) at coldfusion.tagext.lang.IncludeTag.handlePageInvoke(IncludeTag.java:736) at coldfusion.tagext.lang.IncludeTag.doStartTag(IncludeTag.java:572) at coldfusion.runtime.CfJspPage._emptyTcfTag(CfJspPage.java:3011) at cfindex2ecfm944125949._factor8(C:\inetpub\wwwroot\index.cfm:302) at cfindex2ecfm944125949.runPage(C:\inetpub\wwwroot\index.cfm:1) at coldfusion.runtime.CfJspPage.invoke(CfJspPage.java:247) at coldfusion.tagext.lang.IncludeTag.handlePageInvoke(IncludeTag.java:736) at coldfusion.tagext.lang.IncludeTag.doStartTag(IncludeTag.java:572) at coldfusion.runtime.CfJspPage._emptyTcfTag(CfJspPage.java:3011) at cfApplication2ecfc953308886$funcONREQUEST.runFunction(C:\inetpub\wwwroot\Application.cfc:147) at coldfusion.runtime.UDFMethod.invoke(UDFMethod.java:487) at coldfusion.runtime.UDFMethod$ReturnTypeFilter.invoke(UDFMethod.java:420) at coldfusion.runtime.UDFMethod$ArgumentCollectionFilter.invoke(UDFMethod.java:383) at coldfusion.filter.FunctionAccessFilter.invoke(FunctionAccessFilter.java:95) at coldfusion.runtime.UDFMethod.runFilterChain(UDFMethod.java:334) at coldfusion.runtime.UDFMethod.invoke(UDFMethod.java:231) at coldfusion.runtime.TemplateProxy.invoke(TemplateProxy.java:646) at coldfusion.runtime.TemplateProxy.invoke(TemplateProxy.java:435) at coldfusion.runtime.TemplateProxy.invoke(TemplateProxy.java:405) at coldfusion.runtime.AppEventInvoker.invoke(AppEventInvoker.java:108) at coldfusion.runtime.AppEventInvoker.onRequest(AppEventInvoker.java:301) ... 38 more | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Suppressed |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TagContext |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Type | Expression | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
name | onRequest |
Session:
struct | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
authorized | no | ||||||||||||
cfid | 14984483 | ||||||||||||
cftoken | ce6a5ec563f135e5-AA4CF457-5056-B902-14F37AFE137D2CCC | ||||||||||||
confirm_token | 0 | ||||||||||||
confirmed_ind | 0 | ||||||||||||
country | [empty string] | ||||||||||||
[empty string] | |||||||||||||
fname | [empty string] | ||||||||||||
last_login | [empty string] | ||||||||||||
lname | [empty string] | ||||||||||||
locstruct |
|
||||||||||||
opt_in_ind | 0 | ||||||||||||
profession | [empty string] | ||||||||||||
professiontblvar | REF_PROFESSION | ||||||||||||
refspecialtytblvar | REF_SPECIALTY | ||||||||||||
refspectblvar | REF_SPEC | ||||||||||||
sessionid | CLINICALTRIALSLOCATOR_PROD_14984483_ce6a5ec563f135e5-AA4CF457-5056-B902-14F37AFE137D2CCC | ||||||||||||
spec_id | [empty string] | ||||||||||||
sponsored_modal | 0 | ||||||||||||
state_cd | [empty string] | ||||||||||||
u_spec | [empty string] | ||||||||||||
urltoken | CFID=14984483&CFTOKEN=ce6a5ec563f135e5-AA4CF457-5056-B902-14F37AFE137D2CCC | ||||||||||||
user_id | [empty string] | ||||||||||||
user_type | [empty string] | ||||||||||||
zip | [empty string] |
Form:
struct [empty] |
---|
CGI:
struct | |
---|---|
AUTH_PASSWORD | [empty string] |
AUTH_TYPE | [empty string] |
AUTH_USER | [empty string] |
CERT_COOKIE | [empty string] |
CERT_FLAGS | [empty string] |
CERT_ISSUER | [empty string] |
CERT_KEYSIZE | 256 |
CERT_SECRETKEYSIZE | 4096 |
CERT_SERIALNUMBER | [empty string] |
CERT_SERVER_ISSUER | C=US, S=Arizona, L=Scottsdale, O="GoDaddy.com, Inc.", OU=http://certs.godaddy.com/repository/, CN=Go Daddy Secure Certificate Authority - G2 |
CERT_SERVER_SUBJECT | OU=Domain Control Validated, CN=*.clinicaltrialslocator.com |
CERT_SUBJECT | [empty string] |
CF_TEMPLATE_PATH | C:\inetpub\wwwroot\index.cfm |
CONTENT_LENGTH | 0 |
CONTENT_TYPE | [empty string] |
CONTEXT_PATH | [empty string] |
GATEWAY_INTERFACE | CGI/1.1 |
HTTPS | on |
HTTPS_KEYSIZE | 256 |
HTTPS_SECRETKEYSIZE | 4096 |
HTTPS_SERVER_ISSUER | C=US, S=Arizona, L=Scottsdale, O="GoDaddy.com, Inc.", OU=http://certs.godaddy.com/repository/, CN=Go Daddy Secure Certificate Authority - G2 |
HTTPS_SERVER_SUBJECT | OU=Domain Control Validated, CN=*.clinicaltrialslocator.com |
HTTP_ACCEPT | text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8 |
HTTP_ACCEPT_ENCODING | br,gzip |
HTTP_ACCEPT_LANGUAGE | en-US,en;q=0.5 |
HTTP_CONNECTION | Keep-Alive |
HTTP_COOKIE | [empty string] |
HTTP_HOST | clinicaltrialslocator.com |
HTTP_REFERER | [empty string] |
HTTP_URL | [empty string] |
HTTP_USER_AGENT | CCBot/2.0 (https://commoncrawl.org/faq/) |
LOCAL_ADDR | clinicaltrialslocator.com |
PATH_INFO | /index.cfm |
PATH_TRANSLATED | C:\inetpub\wwwroot\index.cfm |
QUERY_STRING | pg=trial-details&nct_id=NCT03910660&srch_radius=0&srch_zip=06828&srch_phase=&alpha_filter=A&actively_recruiting=Y&srch_condition= |
REMOTE_ADDR | 3.238.250.105 |
REMOTE_HOST | 3.238.250.105 |
REMOTE_USER | [empty string] |
REQUEST_METHOD | GET |
SCRIPT_NAME | /index.cfm |
SERVER_NAME | clinicaltrialslocator.com |
SERVER_PORT | 443 |
SERVER_PORT_SECURE | 1 |
SERVER_PROTOCOL | HTTP/1.1 |
SERVER_SOFTWARE | Microsoft-IIS/8.5 |
WEB_SERVER_API | [empty string] |
© 2021 M3 USA Corporation. All Rights Reserved.
Privacy Policy | Terms of Use