Advanced Glycation Endproducts and Bone Material Strength in T2D Treated With Pyridoxamine
Description
The purpose of this study is to determine if a specific form of Vitamin B known as Pyridoxamine helps improve bone strength over one year in women (>65 yrs old) with Type 2 Diabetes. The investigators know that people with type 2 diabetes have the lower bone material strength and the investigators suspect this is due to high levels of circulating sugars that build up over time (known as Advanced Glycation Endproducts). The investigators will study whether using a specific form of vitamin B, known as pyridoxamine helps improve bone strength and reduce levels of circulating sugars over a one year time period.
Study Start Date
March, 01 2018
Estimated Completion Date
December 2020
Interventions
- Drug: placebo
- Drug: Pyridoxamine Dihydrochloride
Study ID
Columbia University -- AAAR5451
Status
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Error Details:
struct | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Cause |
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Detail | An exception occurred while invoking an event handler method from Application.cfc. The method name is: onRequest. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Message | Event handler exception. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RootCause |
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StackTrace | coldfusion.runtime.EventHandlerException: Event handler exception. at coldfusion.runtime.AppEventInvoker.onRequest(AppEventInvoker.java:309) at coldfusion.filter.ApplicationFilter.invoke(ApplicationFilter.java:470) at coldfusion.filter.RequestMonitorFilter.invoke(RequestMonitorFilter.java:42) at coldfusion.filter.MonitoringFilter.invoke(MonitoringFilter.java:40) at coldfusion.filter.PathFilter.invoke(PathFilter.java:153) at coldfusion.filter.ExceptionFilter.invoke(ExceptionFilter.java:94) at coldfusion.filter.BrowserDebugFilter.invoke(BrowserDebugFilter.java:78) at coldfusion.filter.ClientScopePersistenceFilter.invoke(ClientScopePersistenceFilter.java:28) at coldfusion.filter.BrowserFilter.invoke(BrowserFilter.java:38) at coldfusion.filter.NoCacheFilter.invoke(NoCacheFilter.java:58) at coldfusion.filter.GlobalsFilter.invoke(GlobalsFilter.java:38) at coldfusion.filter.DatasourceFilter.invoke(DatasourceFilter.java:22) at coldfusion.filter.CachingFilter.invoke(CachingFilter.java:62) at coldfusion.CfmServlet.service(CfmServlet.java:219) at coldfusion.bootstrap.BootstrapServlet.service(BootstrapServlet.java:89) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:303) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208) at coldfusion.monitor.event.MonitoringServletFilter.doFilter(MonitoringServletFilter.java:42) at coldfusion.bootstrap.BootstrapFilter.doFilter(BootstrapFilter.java:46) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208) at coldfusion.inspect.weinre.MobileDeviceDomInspectionFilter.doFilter(MobileDeviceDomInspectionFilter.java:57) at coldfusion.bootstrap.BootstrapFilter.doFilter(BootstrapFilter.java:46) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208) at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:219) at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:110) at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:494) at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:169) at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:104) at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:116) at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:458) at org.apache.coyote.ajp.AjpProcessor.process(AjpProcessor.java:196) at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:637) at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:316) at java.util.concurrent.ThreadPoolExecutor.runWorker(Unknown Source) at java.util.concurrent.ThreadPoolExecutor$Worker.run(Unknown Source) at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61) at java.lang.Thread.run(Unknown Source) Caused by: coldfusion.runtime.CFPage$InvalidDateException: Date value passed to date function DateDiff is unspecified or invalid. at coldfusion.runtime.CFPage.DateDiff(CFPage.java:1604) at cftrial2ddetails2ecfm1310202973.runPage(C:\inetpub\wwwroot\trial-details.cfm:187) at coldfusion.runtime.CfJspPage.invoke(CfJspPage.java:247) at coldfusion.tagext.lang.IncludeTag.handlePageInvoke(IncludeTag.java:736) at coldfusion.tagext.lang.IncludeTag.doStartTag(IncludeTag.java:572) at coldfusion.runtime.CfJspPage._emptyTcfTag(CfJspPage.java:3011) at cfindex2ecfm944125949._factor8(C:\inetpub\wwwroot\index.cfm:302) at cfindex2ecfm944125949.runPage(C:\inetpub\wwwroot\index.cfm:1) at coldfusion.runtime.CfJspPage.invoke(CfJspPage.java:247) at coldfusion.tagext.lang.IncludeTag.handlePageInvoke(IncludeTag.java:736) at coldfusion.tagext.lang.IncludeTag.doStartTag(IncludeTag.java:572) at coldfusion.runtime.CfJspPage._emptyTcfTag(CfJspPage.java:3011) at cfApplication2ecfc953308886$funcONREQUEST.runFunction(C:\inetpub\wwwroot\Application.cfc:147) at coldfusion.runtime.UDFMethod.invoke(UDFMethod.java:487) at coldfusion.runtime.UDFMethod$ReturnTypeFilter.invoke(UDFMethod.java:420) at coldfusion.runtime.UDFMethod$ArgumentCollectionFilter.invoke(UDFMethod.java:383) at coldfusion.filter.FunctionAccessFilter.invoke(FunctionAccessFilter.java:95) at coldfusion.runtime.UDFMethod.runFilterChain(UDFMethod.java:334) at coldfusion.runtime.UDFMethod.invoke(UDFMethod.java:231) at coldfusion.runtime.TemplateProxy.invoke(TemplateProxy.java:646) at coldfusion.runtime.TemplateProxy.invoke(TemplateProxy.java:435) at coldfusion.runtime.TemplateProxy.invoke(TemplateProxy.java:405) at coldfusion.runtime.AppEventInvoker.invoke(AppEventInvoker.java:108) at coldfusion.runtime.AppEventInvoker.onRequest(AppEventInvoker.java:301) ... 38 more | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Suppressed |
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TagContext |
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Type | Expression | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
name | onRequest |
Session:
struct | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
authorized | no | ||||||||||||
cfid | 14984548 | ||||||||||||
cftoken | 9ad20f0ac2621ce3-AA7BA0A3-5056-B902-1491889DBA21CBE0 | ||||||||||||
confirm_token | 0 | ||||||||||||
confirmed_ind | 0 | ||||||||||||
country | [empty string] | ||||||||||||
[empty string] | |||||||||||||
fname | [empty string] | ||||||||||||
last_login | [empty string] | ||||||||||||
lname | [empty string] | ||||||||||||
locstruct |
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opt_in_ind | 0 | ||||||||||||
profession | [empty string] | ||||||||||||
professiontblvar | REF_PROFESSION | ||||||||||||
refspecialtytblvar | REF_SPECIALTY | ||||||||||||
refspectblvar | REF_SPEC | ||||||||||||
sessionid | CLINICALTRIALSLOCATOR_PROD_14984548_9ad20f0ac2621ce3-AA7BA0A3-5056-B902-1491889DBA21CBE0 | ||||||||||||
spec_id | [empty string] | ||||||||||||
sponsored_modal | 0 | ||||||||||||
state_cd | [empty string] | ||||||||||||
u_spec | [empty string] | ||||||||||||
urltoken | CFID=14984548&CFTOKEN=9ad20f0ac2621ce3-AA7BA0A3-5056-B902-1491889DBA21CBE0 | ||||||||||||
user_id | [empty string] | ||||||||||||
user_type | [empty string] | ||||||||||||
zip | [empty string] |
Form:
struct [empty] |
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CGI:
struct | |
---|---|
AUTH_PASSWORD | [empty string] |
AUTH_TYPE | [empty string] |
AUTH_USER | [empty string] |
CERT_COOKIE | [empty string] |
CERT_FLAGS | [empty string] |
CERT_ISSUER | [empty string] |
CERT_KEYSIZE | 256 |
CERT_SECRETKEYSIZE | 4096 |
CERT_SERIALNUMBER | [empty string] |
CERT_SERVER_ISSUER | C=US, S=Arizona, L=Scottsdale, O="GoDaddy.com, Inc.", OU=http://certs.godaddy.com/repository/, CN=Go Daddy Secure Certificate Authority - G2 |
CERT_SERVER_SUBJECT | OU=Domain Control Validated, CN=*.clinicaltrialslocator.com |
CERT_SUBJECT | [empty string] |
CF_TEMPLATE_PATH | C:\inetpub\wwwroot\index.cfm |
CONTENT_LENGTH | 0 |
CONTENT_TYPE | [empty string] |
CONTEXT_PATH | [empty string] |
GATEWAY_INTERFACE | CGI/1.1 |
HTTPS | on |
HTTPS_KEYSIZE | 256 |
HTTPS_SECRETKEYSIZE | 4096 |
HTTPS_SERVER_ISSUER | C=US, S=Arizona, L=Scottsdale, O="GoDaddy.com, Inc.", OU=http://certs.godaddy.com/repository/, CN=Go Daddy Secure Certificate Authority - G2 |
HTTPS_SERVER_SUBJECT | OU=Domain Control Validated, CN=*.clinicaltrialslocator.com |
HTTP_ACCEPT | text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8 |
HTTP_ACCEPT_ENCODING | br,gzip |
HTTP_ACCEPT_LANGUAGE | en-US,en;q=0.5 |
HTTP_CONNECTION | Keep-Alive |
HTTP_COOKIE | [empty string] |
HTTP_HOST | clinicaltrialslocator.com |
HTTP_REFERER | [empty string] |
HTTP_URL | [empty string] |
HTTP_USER_AGENT | CCBot/2.0 (https://commoncrawl.org/faq/) |
LOCAL_ADDR | clinicaltrialslocator.com |
PATH_INFO | /index.cfm |
PATH_TRANSLATED | C:\inetpub\wwwroot\index.cfm |
QUERY_STRING | pg=trial-details&nct_id=NCT03778580&srch_radius=0&srch_zip=06828&srch_phase=&alpha_filter=A&actively_recruiting=Y&srch_condition= |
REMOTE_ADDR | 3.238.250.105 |
REMOTE_HOST | 3.238.250.105 |
REMOTE_USER | [empty string] |
REQUEST_METHOD | GET |
SCRIPT_NAME | /index.cfm |
SERVER_NAME | clinicaltrialslocator.com |
SERVER_PORT | 443 |
SERVER_PORT_SECURE | 1 |
SERVER_PROTOCOL | HTTP/1.1 |
SERVER_SOFTWARE | Microsoft-IIS/8.5 |
WEB_SERVER_API | [empty string] |
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