A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief


The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of surgery, compared to the patients that doctors use only EXPAREL® or bupivacaine to manage their pain. This information will help doctors determine which approach works best for patients who will receive surgery in their lumbar spine in the future.

Study Start Date

December, 01 2016

Estimated Completion Date

December 2019


  • Drug: Exparel
  • Drug: Bupivacaine

Study ID

Virtua Health, Inc. -- VirtuaHealthExparel



Trial ID


Study Type


Trial Phase

Phase 4

Enrollment Quota



Virtua Health, Inc.

Inclusion Criteria

    1. Age 18 or older 2. Primary indication is low back pain, lumbosacral radiculopathy, lumbar disc degeneration, lumbar disc herniation, stenosis, spondylolisthesis, spondylolysis, or deformity requiring surgical intervention 3. Scheduled to undergo primary, 1 or 2 level, posterior lumbar laminectomy with or without fusion, discectomy with fusion, or fusion at Virtua Memorial Hospital 4. Willing to provide informed consent, participate in study, and comply with study protocol.

Exclusion Criteria

    1. Hypersensitivity or allergy to local anesthetics 2. Pregnant or contemplating pregnancy prior to surgery 3. Previous surgery in lumbar spine (i.e. other than microdiscectomy) 4. Prior treatment for alcohol, recreational drug, or opioid abuse 5. Serious spinal conditions (e.g. spinal cord compression, cauda equina syndrome, spinal infection, spinal tumor, spinal fracture, inflammatory or systemic spinal arthritis) 6. Surgery involving more than 2 vertebral levels 7. Worker's compensation or personal injury related to lumbar spine (treatment outcomes may be affected by patient's personal interests [21] could also run into potential issues with reimbursement). 8. Lactating women 9. Patients with end stage liver disease




18 Years and older

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Virtua Memorial Hospital - Mount Holly, New Jersey 118.0 miles Robert Greenleaf MD 609-267-9400 bob.greenleaf1@gmail.com

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