The TCF7L2 Gene: Dietary Prevention of T2DM
Nutrients and chemicals in food are able to regulate expression of genetic elements. Gene-nutrient interaction in response specific diets can increase an individual's risk, shifting the individual from health toward the development of chronic disease. The Transcription Factor 7 Like 2 (TCF7L2) gene may either put individuals at risk for or protect from Type 2 diabetes mellitus in the presence of certain foods. The main purpose of this four-week study is to examine diet-induced gene-nutrient interaction, with a focus on glucose, insulin, inflammation (CRP) and the plasma metabolome in individuals who have either the CC or the TT form of the rs7903146 single nucleotide polymorphism (SNP) (C/T) within the TCF7L2 gene. The (2) one-week study diets, one Mediterranean diet (MedDiet) based and the other low-fat based will be separated by a (1) week return to a regular habitual diet.
Study Start Date
February, 15 2018
Estimated Completion Date
- Other: Mediterranean Diet
- Other: Low-fat diet
Tufts University -- TCF7L2_2965
- Men and women.
- 18 years or older.
- Women who are not pregnant.
- A BMI ranging between 27 and 34
- Unexplained elevation in serum transaminases (i.e. >1.5 times the upper limit of normal) or with evidence of active liver disease, including primary biliary cirrhosis or pre-existing gallbladder disease.
- Severe renal dysfunction (serum creatinine >2.0mg/dL).
- Excessive alcohol consumption (>2 drinks/day).
- Preexisting CVD.
- Stable exertional angina pectoris requiring sublingual nitroglycerin within the prior 3 months.
- Uncontrolled T2D (fasting glucose >126 mg/dl) or other significant endocrine disease.
- Uncontrolled hypertension (systolic blood pressure >180 mmHg or diastolic blood pressure >100 mmHg).
- History of pancreatitis within 1 yr. prior to screening.
- Subjects on lipid-lowering or diabetes medications.
- Body mass index (BMI) below 27 or greater than 34 kg/m2
- Participants will also be excluded for drug abuse, extreme dietary habits, multiple food allergies, extreme levels of physical or athletic activity, or by changes in body weight >20 lbs. during the last 6 months.
- Inability to follow any of the experimental diets or to perform the sampling required for this study.
- Thyroid diseases.
- Use of omega-3 supplements (unless it is discontinued one month prior to the beginning of the study).
18 Years and older
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Study Locations and Contact Information (1)
|JMUSDA Human Nutrition Research Center on Aging at Tufts University - Boston, Massachusetts||3.2 miles||Cheryl H Gilhooly PHD RD||617-556-3154||Cheryl.Gilhooly@tufts.edu|