Neural and Mobile Assessment OF Behavior Change Among Problem Drinkers

Description

This study will examine the neural mechanisms underlying both spontaneous behavior change and behavior change in response to a brief intervention among problem drinkers.

Study Start Date

February, 27 2018

Estimated Completion Date

February 2022

Interventions

  • Behavioral: Brief intervention

Study ID

New York State Psychiatric Institute -- 7390

Status

Recruiting

Trial ID

NCT03457077

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

150

Sponsor

New York State Psychiatric Institute

Inclusion Criteria (Problem Drinkers):
  • Age 21-55
  • English language fluency
  • Strongly right-handed
  • Have an average weekly consumption of greater than 14 standard drinks for women, and greater than 24 standard drinks for men.
  • Current DSM-V mild or moderate alcohol use disorder (AUD) diagnosis Inclusion Criteria (Healthy Controls):
  • Age 21-55
  • English language fluency
  • Strongly right-handed
  • Have an average weekly consumption of less than 7 standard drinks for women and less than 14 standard drinks for men and no heavy drinking days (>4/5 standard drinks for a woman/man)
  • No lifetime diagnosis of AUD

    Exclusion Criteria

    • Past or current severe AUD as defined by DSM
    • V
    • Currently seeking treatment or attempting to stop drinking
    • Past or current alcohol withdrawal symptoms
    • Current DSM-V diagnosis of substance use disorder (other than nicotine or caffeine).
    • Recent use (past month, more than weekly) of recreational drugs.
    • Current or recent (past 5 years) Major Depressive Disorder, Psychotic Disorder, Bipolar
    • Substantial risk of suicide or violence
    • MRI contraindications (e.g., metallic implants, pacemaker, weight > 350 lbs, waist > 55")
    • Hearing impaired/hearing aids, unable to read newspaper at arm's length with corrective
    • Objective cognitive impairment
    • Current or recent (evidence of disease x 5 years) non-skin neoplastic disease or melanoma.
    • Active hepatic disease (not a history of hepatitis) or primary renal disease requiring dialysis, primary untreated endocrine diseases, e.g., Cushing's disease or primary hypothalamic failure or insulin dependent diabetes (Type I or II). Well-treated hypothyroidism will not be excluded.
    • HIV infection
    • Pregnant, lactating (participation allowed 3 months after ceasing lactation), or currently intending to become pregnant
    • Medications that target CNS (e.g., neuroleptics, anticonvulsants, antidepressants, benzodiazepines) within the last month.
    • Any history of ECT
    • Brain disorder such as stroke, tumor, infection, epilepsy, multiple sclerosis, degenerative diseases, head injury (LOC > 5 minutes), mental retardation
    • Diagnosed learning disability, dyslexia, or ADHD
    • For women: Current pregnancy or intention to be pregnant in the near future
  • Gender

    All

    Ages

    21 Years to 55 Years

    Accepts Healthy Volunteers

    Accepts Healthy Volunteers

    Study Locations and Contact Information (1)

    Study Location Distance Name Phone Email
    NYPInstitute - New York, New York 44.8 miles Nasir H Naqvi MD PhD 212-923-3031 nhn2102@columbia.edu

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