Biology of Juvenile Myoclonic Epilepsy

Description

The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.

Study Start Date

July, 13 2017

Estimated Completion Date

June 2020

Interventions

  • Other: Blood draw
  • Other: Existing samples

Study ID

King's College London -- 199351

Status

Unknown

Trial ID

NCT03400371

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

1000

Sponsor

King's College London

Inclusion Criteria

  • Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria
  • Age of myoclonus onset 10-25 years
  • Seizures comprising predominant or exclusive early morning myoclonus of upper extremities
  • EEG interictal generalized spikes and/or polyspike and waves with normal background
  • Current age 10-40 years

Exclusion Criteria

  • Myoclonus only associated with carbamazepine or lamotrigine therapy
  • EEG showing predominant focal interictal epileptiform discharges or abnormal background
  • Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures
  • Global learning disability
  • Dysmorphic syndrome
  • Unable to provide informed consent

Gender

All

Ages

10 Years to 40 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (3)

Study Location Distance Name Phone Email
St Lukes Roosevelt Hospital - New York, New York 47.4 miles Professor Steven Wolf None None
Mount SinaiBeth Israel Medical Center - New York, New York 51.3 miles Professor Steven Wolf None None
Nationwide Childrens Hospital - Columbus, Ohio 515.5 miles David A Greenberg None None

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