Biology of Juvenile Myoclonic Epilepsy

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Description

The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.

Study Start Date

July, 13 2017

Estimated Completion Date

June 2020

Interventions

Other: Blood draw
Other: Existing samples

Study ID

King's College London -- 199351

Status

Unknown

Trial ID

NCT03400371

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

1000

Sponsor

King's College London

Inclusion Criteria

Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria
Age of myoclonus onset 10-25 years
Seizures comprising predominant or exclusive early morning myoclonus of upper extremities
EEG interictal generalized spikes and/or polyspike and waves with normal background
Current age 10-40 years

Exclusion Criteria

Myoclonus only associated with carbamazepine or lamotrigine therapy
EEG showing predominant focal interictal epileptiform discharges or abnormal background
Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures
Global learning disability
Dysmorphic syndrome
Unable to provide informed consent

Gender

All

Ages

10 Years to 40 Years

Accepts Healthy Volunteers

Study Locations and Contact Information (3)

Study Location	Distance	Name	Phone	Email
St Lukes Roosevelt Hospital - New York, New York	47.4 miles	Professor Steven Wolf	None	None
Mount SinaiBeth Israel Medical Center - New York, New York	51.3 miles	Professor Steven Wolf	None	None
Nationwide Childrens Hospital - Columbus, Ohio	515.5 miles	David A Greenberg	None	None

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