Biology of Juvenile Myoclonic Epilepsy
Description
The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.
Study Start Date
July, 13 2017
Estimated Completion Date
June 2020
Interventions
- Other: Blood draw
- Other: Existing samples
Study ID
King's College London -- 199351
Status
Unknown
Trial ID
Study Type
Observational
Trial Phase
N/A
Enrollment Quota
1000
Sponsor
King's College London
Inclusion Criteria
- Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria
- Age of myoclonus onset 10-25 years
- Seizures comprising predominant or exclusive early morning myoclonus of upper extremities
- EEG interictal generalized spikes and/or polyspike and waves with normal background
- Current age 10-40 years
Exclusion Criteria
- Myoclonus only associated with carbamazepine or lamotrigine therapy
- EEG showing predominant focal interictal epileptiform discharges or abnormal background
- Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures
- Global learning disability
- Dysmorphic syndrome
- Unable to provide informed consent
Gender
All
Ages
10 Years to 40 Years
Accepts Healthy Volunteers
No
Study Locations and Contact Information (3)
Study Location | Distance | Name | Phone | |
---|---|---|---|---|
St Lukes Roosevelt Hospital - New York, New York | 47.4 miles | Professor Steven Wolf | None | None |
Mount SinaiBeth Israel Medical Center - New York, New York | 51.3 miles | Professor Steven Wolf | None | None |
Nationwide Childrens Hospital - Columbus, Ohio | 515.5 miles | David A Greenberg | None | None |