Circulating RNAs in Acute Congestive Heart Failure

Description

The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo. The investigators are testing the hypothesis that ex-RNA levels change significantly during decongestion therapy and can be used as a marker of those individuals who respond to CHF therapy (in terms of cardiac structure or outcome). Additionally, the translational research design allows the investigators to assay the effects of these RNAs on tissue phenotypes in vitro.

Study Start Date

August, 17 2016

Estimated Completion Date

June 2020

Interventions

  • Diagnostic Test: Cardiac MRI

Study ID

Massachusetts General Hospital -- 2016P001250

Status

Recruiting

Trial ID

NCT03345446

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

200

Sponsor

Massachusetts General Hospital

Inclusion Criteria

    1. Age >/= 18 years of age 2. Assessment of LV function within the last year or planned during hospital admission 3. Acute CHF diagnosis, requiring clinical signs and/or symptoms (including exertional or rest dyspnea, orthopnea or PND) AND 1. N-terminal pro-BNP level > 1000 pg/ml or BNP > 400 pg/ml, OR 2. Clinical evidence of congestion:
  • X-ray evidence of pulmonary edema or pleural effusions
  • Elevated JVP, lower extremity edema, or rales on pulmonary examination
  • Right heart catheterization evidence of elevated filling pressures (RA pressure > 10 mmHg
  • PCWP > 18 mmHg) 4. Clinical response to IV diuretic therapy (as judged by a physician)

Exclusion Criteria

    1. Hematocrit at time of consent < 30% 2. End-stage non-cardiovascular diseases 1. Known HIV/AIDS 2. Cirrhosis 3. Hemodialysis-dependent renal failure 3. Pregnancy (as adjudicated by patient history) 4. Ventricular assist device support 5. Acute mechanical support on admission 6. Post-heart transplant 7. Malignancy within the last 1 year or clinically active rheumatologic or autoimmune illnesses

Gender

All

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (3)

Study Location Distance Name Phone Email
Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.4 miles Pablo Quintero Pinzon MD 617-667-7000 pquinter@bidmc.harvard.edu
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Michael JeroschHerold PhD 617-525-8959 jeroschherold@gmail.clm
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles Saumya Das MD PhD 617-726-2000 sdas@partners.org

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