Circulating RNAs in Acute Congestive Heart Failure


The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo. The investigators are testing the hypothesis that ex-RNA levels change significantly during decongestion therapy and can be used as a marker of those individuals who respond to CHF therapy (in terms of cardiac structure or outcome). Additionally, the translational research design allows the investigators to assay the effects of these RNAs on tissue phenotypes in vitro.

Study Start Date

August, 17 2016

Estimated Completion Date

June 2020


  • Diagnostic Test: Cardiac MRI

Study ID

Massachusetts General Hospital -- 2016P001250



Trial ID


Study Type


Trial Phase


Enrollment Quota



Massachusetts General Hospital

Inclusion Criteria

    1. Age >/= 18 years of age 2. Assessment of LV function within the last year or planned during hospital admission 3. Acute CHF diagnosis, requiring clinical signs and/or symptoms (including exertional or rest dyspnea, orthopnea or PND) AND 1. N-terminal pro-BNP level > 1000 pg/ml or BNP > 400 pg/ml, OR 2. Clinical evidence of congestion:
  • X-ray evidence of pulmonary edema or pleural effusions
  • Elevated JVP, lower extremity edema, or rales on pulmonary examination
  • Right heart catheterization evidence of elevated filling pressures (RA pressure > 10 mmHg
  • PCWP > 18 mmHg) 4. Clinical response to IV diuretic therapy (as judged by a physician)

Exclusion Criteria

    1. Hematocrit at time of consent < 30% 2. End-stage non-cardiovascular diseases 1. Known HIV/AIDS 2. Cirrhosis 3. Hemodialysis-dependent renal failure 3. Pregnancy (as adjudicated by patient history) 4. Ventricular assist device support 5. Acute mechanical support on admission 6. Post-heart transplant 7. Malignancy within the last 1 year or clinically active rheumatologic or autoimmune illnesses




18 Years and older

Accepts Healthy Volunteers


Study Locations and Contact Information (3)

Study Location Distance Name Phone Email
Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.4 miles Pablo Quintero Pinzon MD 617-667-7000
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Michael JeroschHerold PhD 617-525-8959 jeroschherold@gmail.clm
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles Saumya Das MD PhD 617-726-2000 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.