PERL Continuous Glucose Monitoring (CGM) Study

Description

Seven-point capillary profiles have shown that mean glucose correlates with both diabetic retinopathy and nephropathy risk. However, there remains great controversy as to whether the degree of variability around mean glucose may also contribute to these microvascular complications. The PERL trial (NCT02017171), testing whether treatment with allopurinol can slow down kidney function loss in type 1 diabetes, provides a unique opportunity to assess the role of glycemic variability in the progression of diabetic kidney disease in individuals who already have mild to moderate kidney disease. By applying Continuous Glucose Monitoring (CGM) in the PERL Study population, the investigators will be able to better understand how metrics of glycemia (mean, time above and below range, and various measures of variability) are associated with renal outcomes in the PERL population as a whole, but also in important subgroups (e.g., albuminuric vs. normoalbuminuric subjects with ongoing GFR decline, allopurinol vs. placebo arms). The nvestigators also aim to obtain precise information on the range of blood glucose corresponding to any given HbA1c value in this population since previous studies generally excluded patients with renal disease.

Study Start Date

October, 01 2017

Estimated Completion Date

August 2019

Interventions

  • Other: Mean blood glucose
  • Other: % time above 250 mg/dL
  • Drug: Placebo
  • Other: Blood glucose CV
  • Drug: Allopurinol
  • Other: HBGI (High Blood Glucose Index)
  • Other: % time above 180 mg/dL
  • Other: MAGE (Mean amplitude of glucose excursions)
  • Other: % time 70-180 mg/dL
  • Other: % time below 54 mg/dL
  • Other: LBGI (Low Blood Glucose Index)

Study ID

Joslin Diabetes Center -- 2018PG-T1D014

Status

Recruiting

Trial ID

NCT03334318

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

300

Sponsor

Joslin Diabetes Center

Inclusion Criteria

    • Being an active participant in the PERL clinical trial

Exclusion Criteria

  • Having completed PERL Visit 16
  • Pregnancy
  • History of skin reactions in relation to the application of Abbott Freestyle Libre Pro

Gender

All

Ages

18 Years to 70 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (64)

Study Location Distance Name Phone Email
Joslin Diabetes Center - Boston, Massachusetts 2.4 miles Alessandro Doria MD PhD MPH 617-309-2406 alessandro.doria@joslin.harvard.edu
Joslin Diabetes Center - Boston, Massachusetts 2.4 miles Alessandro Doria MD PhD MPH 617-309-2406 alessandro.doria@joslin.harvard.edu
Joslin Diabetes Center - Boston, Massachusetts 2.4 miles Alessandro Doria MD PhD MPH 617-309-2406 alessandro.doria@joslin.harvard.edu
Joslin Diabetes Center - Boston, Massachusetts 2.4 miles Alessandro Doria MD PhD MPH 617-309-2406 alessandro.doria@joslin.harvard.edu
Joslin Diabetes Center - Boston, Massachusetts 2.4 miles Alessandro Doria MD PhD MPH 617-309-2406 alessandro.doria@joslin.harvard.edu
Albert Einstein College of Medicine Montefiore Medical Center - The Bronx, New York 176.6 miles Danielle Powell MPH 718-405-8271 PERL@einstein.yu.edu
Albert Einstein College of Medicine Montefiore Medical Center - The Bronx, New York 176.6 miles Danielle Powell MPH 718-405-8271 PERL@einstein.yu.edu
Albert Einstein College of Medicine Montefiore Medical Center - The Bronx, New York 176.6 miles Danielle Powell MPH 718-405-8271 PERL@einstein.yu.edu
Albert Einstein College of Medicine Montefiore Medical Center - The Bronx, New York 176.6 miles Danielle Powell MPH 718-405-8271 PERL@einstein.yu.edu
Albert Einstein College of Medicine Montefiore Medical Center - The Bronx, New York 176.6 miles Danielle Powell MPH 718-405-8271 PERL@einstein.yu.edu
ICAHN School of Medicine at Mount Sinai - New York, New York 183.2 miles Selassie Ogyaadu 212-241-9089 Selassie.Ogyaadu@mssm.edu
ICAHN School of Medicine at Mount Sinai - New York, New York 183.2 miles Selassie Ogyaadu 212-241-9089 Selassie.Ogyaadu@mssm.edu
ICAHN School of Medicine at Mount Sinai - New York, New York 183.2 miles Selassie Ogyaadu 212-241-9089 Selassie.Ogyaadu@mssm.edu
ICAHN School of Medicine at Mount Sinai - New York, New York 183.2 miles Selassie Ogyaadu 212-241-9089 Selassie.Ogyaadu@mssm.edu
SUNY Upstate Medical University - Syracuse, New York 259.8 miles Suzan Bzdick RN CCRC 315-464-9006 bzdicks@upstate.edu
SUNY Upstate Medical University - Syracuse, New York 259.8 miles Suzan Bzdick RN CCRC 315-464-9006 bzdicks@upstate.edu
SUNY Upstate Medical University - Syracuse, New York 259.8 miles Suzan Bzdick RN CCRC 315-464-9006 bzdicks@upstate.edu
SUNY Upstate Medical University - Syracuse, New York 259.8 miles Suzan Bzdick RN CCRC 315-464-9006 bzdicks@upstate.edu
SUNY Upstate Medical University - Syracuse, New York 259.8 miles Suzan Bzdick RN CCRC 315-464-9006 bzdicks@upstate.edu
Henry Ford Health System - Detroit, Michigan 612.3 miles Heather Remtema MPH RD CCRP (313) 916-3906 hremtem1@hfhs.org
Henry Ford Health System - Detroit, Michigan 612.3 miles Heather Remtema MPH RD CCRP (313) 916-3906 hremtem1@hfhs.org
Henry Ford Health System - Detroit, Michigan 612.3 miles Heather Remtema MPH RD CCRP (313) 916-3906 hremtem1@hfhs.org
Henry Ford Health System - Detroit, Michigan 612.3 miles Heather Remtema MPH RD CCRP (313) 916-3906 hremtem1@hfhs.org
Henry Ford Health System - Detroit, Michigan 612.3 miles Heather Remtema MPH RD CCRP (313) 916-3906 hremtem1@hfhs.org
Brehm Center for Diabetes Research University of Michigan - Ann Arbor, Michigan 644.6 miles Ginny Leone MA 734-936-8656 vleone@med.umich.edu
Brehm Center for Diabetes Research University of Michigan - Ann Arbor, Michigan 644.6 miles Ginny Leone MA 734-936-8656 vleone@med.umich.edu
Brehm Center for Diabetes Research University of Michigan - Ann Arbor, Michigan 644.6 miles Ginny Leone MA 734-936-8656 vleone@med.umich.edu
Brehm Center for Diabetes Research University of Michigan - Ann Arbor, Michigan 644.6 miles Ginny Leone MA 734-936-8656 vleone@med.umich.edu
Brehm Center for Diabetes Research University of Michigan - Ann Arbor, Michigan 644.6 miles Ginny Leone MA 734-936-8656 vleone@med.umich.edu
Northwestern University Feinberg School of Medicine - Chicago, Illinois 847.9 miles Diane Larsen 312-503-2873 d-larsen@northwestern.edu
Northwestern University Feinberg School of Medicine - Chicago, Illinois 847.9 miles Diane Larsen 312-503-2873 d-larsen@northwestern.edu
Emory University Grady Memorial Hospital - Atlanta, Georgia 936.6 miles Clementina Ramos MD 404-616-3951 clemenramos@emory.edu
Emory University Grady Memorial Hospital - Atlanta, Georgia 936.6 miles Clementina Ramos MD 404-616-3951 clemenramos@emory.edu
Emory University Grady Memorial Hospital - Atlanta, Georgia 936.6 miles Clementina Ramos MD 404-616-3951 clemenramos@emory.edu
Emory University Grady Memorial Hospital - Atlanta, Georgia 936.6 miles Clementina Ramos MD 404-616-3951 clemenramos@emory.edu
Emory University Grady Memorial Hospital - Atlanta, Georgia 936.6 miles Clementina Ramos MD 404-616-3951 clemenramos@emory.edu
Washington University - Saint Louis, Missouri 1,039.5 miles Carol Recklein RN MHS CDE 314-362-8606 crecklein@dom.wustl.edu
Washington University - Saint Louis, Missouri 1,039.5 miles Carol Recklein RN MHS CDE 314-362-8606 crecklein@dom.wustl.edu
Washington University - Saint Louis, Missouri 1,039.5 miles Carol Recklein RN MHS CDE 314-362-8606 crecklein@dom.wustl.edu
Washington University - Saint Louis, Missouri 1,039.5 miles Carol Recklein RN MHS CDE 314-362-8606 crecklein@dom.wustl.edu
Washington University - Saint Louis, Missouri 1,039.5 miles Carol Recklein RN MHS CDE 314-362-8606 crecklein@dom.wustl.edu
University of Minnesota - Minneapolis, Minnesota 1,120.0 miles Madeleine Hermans 612-626-3286 herma583@umn.edu
University of Minnesota - Minneapolis, Minnesota 1,120.0 miles Madeleine Hermans 612-626-3286 herma583@umn.edu
University of Minnesota - Minneapolis, Minnesota 1,120.0 miles Madeleine Hermans 612-626-3286 herma583@umn.edu
Barbara Davis Center University of Colorado Denver - Aurora, Colorado 1,759.8 miles Victoria Gage RN BSN CDE 303-724-8369 Victoria.Gage@ucdenver.edu
Barbara Davis Center University of Colorado Denver - Aurora, Colorado 1,759.8 miles Victoria Gage RN BSN CDE 303-724-8369 Victoria.Gage@ucdenver.edu
Barbara Davis Center University of Colorado Denver - Aurora, Colorado 1,759.8 miles Victoria Gage RN BSN CDE 303-724-8369 Victoria.Gage@ucdenver.edu
Barbara Davis Center University of Colorado Denver - Aurora, Colorado 1,759.8 miles Victoria Gage RN BSN CDE 303-724-8369 Victoria.Gage@ucdenver.edu
Barbara Davis Center University of Colorado Denver - Aurora, Colorado 1,759.8 miles Victoria Gage RN BSN CDE 303-724-8369 Victoria.Gage@ucdenver.edu
Providence Sacred Heart Medical Center - Spokane, Washington 2,266.1 miles Mary Bates RN 509-474-4962 mary.bates@providence.org
Providence Sacred Heart Medical Center - Spokane, Washington 2,266.1 miles Mary Bates RN 509-474-4962 mary.bates@providence.org
Providence Sacred Heart Medical Center - Spokane, Washington 2,266.1 miles Mary Bates RN 509-474-4962 mary.bates@providence.org
Providence Sacred Heart Medical Center - Spokane, Washington 2,266.1 miles Mary Bates RN 509-474-4962 mary.bates@providence.org
Providence Sacred Heart Medical Center - Spokane, Washington 2,266.1 miles Mary Bates RN 509-474-4962 mary.bates@providence.org
University of Washington - Seattle, Washington 2,487.2 miles Dawn Lum 206-685-4633 PERL-UW@nephrology.washington.edu
University of Washington - Seattle, Washington 2,487.2 miles Dawn Lum 206-685-4633 PERL-UW@nephrology.washington.edu
University of Washington - Seattle, Washington 2,487.2 miles Dawn Lum 206-685-4633 PERL-UW@nephrology.washington.edu
University of Washington - Seattle, Washington 2,487.2 miles Dawn Lum 206-685-4633 PERL-UW@nephrology.washington.edu
University of Washington - Seattle, Washington 2,487.2 miles Dawn Lum 206-685-4633 PERL-UW@nephrology.washington.edu
Virginia Mason Medical Center - Seattle, Washington 2,489.8 miles Katherine Wilder 206-223-6169 katherine.wilder@virginiamason.org
Virginia Mason Medical Center - Seattle, Washington 2,489.8 miles Katherine Wilder 206-223-6169 katherine.wilder@virginiamason.org
Virginia Mason Medical Center - Seattle, Washington 2,489.8 miles Katherine Wilder 206-223-6169 katherine.wilder@virginiamason.org
Virginia Mason Medical Center - Seattle, Washington 2,489.8 miles Katherine Wilder 206-223-6169 katherine.wilder@virginiamason.org
Virginia Mason Medical Center - Seattle, Washington 2,489.8 miles Katherine Wilder 206-223-6169 katherine.wilder@virginiamason.org

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