Dose Escalation Study of mRNA 2416 for Intratumoral Injection to Patients With Advanced Malignancies


This clinical study will assess the safety and tolerability of escalating intratumoral doses of mRNA 2416 in patients with relapsed/refractory solid tumor malignancies or lymphoma

Study Start Date

August, 09 2017

Estimated Completion Date

July 2019


  • Biological: mRNA-2416

Study ID

Moderna Therapeutics -- mRNA-2416-P101



Trial ID


Study Type


Trial Phase

Phase 1

Enrollment Quota



Moderna Therapeutics

Inclusion Criteria

  • Written informed consent prior to completing any study-specific procedure
  • Histologically
  • or cytologically-confirmed advanced/metastatic solid tumor or lymphoma that is refractory to standard therapies, or the patient refuses standard therapy
  • Eastern Cooperative Oncology Group (ECOG) performance status of ? 2
  • Adequate hematological and biological function
  • Female patients of childbearing potential must have a negative serum pregnancy test
  • Male and female patients must agree to use a highly reliable method of birth control.

Exclusion Criteria

  • Active central nervous system tumors or metastases
  • Treatment with prohibited medications (eg, concurrent anti-cancer therapy including other chemotherapy, radiation (local radiation for palliative care is permitted), hormonal anti-cancer treatment, biologic therapy, or immunotherapy) < 28 days prior to the first day of study treatment
  • Active or prior autoimmune disorder within the past 2 years
  • History of primary immunodeficiency, solid organ transplantation, or tuberculosis
  • Any plan to receive a live attenuated vaccine during study treatment
  • History of human immunodeficiency virus infection (testing is not required)
  • Active/chronic hepatitis B or C
  • Females who are pregnant or breastfeeding




18 Years and older

Accepts Healthy Volunteers


Study Locations and Contact Information (7)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles None None None
Henry Ford Hospital - Detroit, Michigan 612.3 miles None None None
Sarah Cannon Research Institute - Nashville, Tennessee 942.8 miles None None None
University of Minnesota Medical Center - Minneapolis, Minnesota 1,120.0 miles None None None
University of Colorado Hospital - Aurora, Colorado 1,759.8 miles None None None
Huntsman Cancer Institute - Salt Lake City, Utah 2,094.1 miles None None None
Mayo Clinic - Phoenix, Arizona 2,284.5 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.