Short-Term Endogenous Hydrogen Sulfide Upregulation

Description

This research study will compare the impact of dietary restriction pre-operatively before carotid endarterectomy compared to the standard nutrition that a patient typically eats. The investigators want to find out how patients comply and generally how well patients do with this type of dietary restriction before their surgery since animal studies suggest that short - term dietary restriction may be beneficial before surgery.

Study Start Date

September, 14 2017

Estimated Completion Date

June 2018

Interventions

  • Dietary Supplement: ScandiShake

Study ID

Brigham and Women's Hospital -- 2016P002507

Status

Recruiting

Trial ID

NCT03303534

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

40

Sponsor

Brigham and Women's Hospital

Inclusion Criteria

  • consenting adults (men and women)
  • clinical indication for carotid endarterectomy (CEA) as determined by attending vascular surgeon
  • if symptomatic, patients must be able to safely have surgery timed for PCR intervention

Exclusion Criteria

  • intolerance or allergy to any ingredients in the PCR diet (ScandiShake ingredients or almond milk/nuts)
  • active infection
  • pregnancy
  • malnutrition determined by serum albumin lower than BWH reference value of 3.5 g/dL
  • active drug dependency or alcoholism that could interfere with protocol adherence
  • active non-cutaneous cancer under treatment with chemotherapeutic

Gender

All

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (5)

Study Location Distance Name Phone Email
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Charles Keith Ozaki MD None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Charles Keith Ozaki MD None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Charles Keith Ozaki MD None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Charles Keith Ozaki MD None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Charles Keith Ozaki MD None None

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