Minimal Residual Disease in Peripheral T-cell Lymphoma

Description

As T-cell receptor sequencing by LymphoTrack is an assay with high sensitivity that can be performed in peripheral blood, the investigators wish to evaluate the ability of this assay to predict which patients are at higher risk of relapse from T-cell lymphoma. Additionally, as more is known about the ability of dynamic monitoring of cfDNA in B-cell lymphomas to predict relapse, the investigators wish to explore the use of this technology in T-cell lymphomas.

Study Start Date

July, 31 2017

Estimated Completion Date

July 2021

Interventions

  • Procedure: Peripheral blood draw
  • Procedure: Tumor biopsy
  • Device: Lymphotrack TCR clonality assay

Study ID

Washington University School of Medicine -- 201706050

Status

Recruiting

Trial ID

NCT03297697

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

42

Sponsor

Washington University School of Medicine

Inclusion Criteria

  • At least 18 years of age.
  • Histologically-confirmed peripheral T-cell lymphoma being treated with curative intent. Eligible histologies include: peripheral T-cell lymphoma, not otherwise specified
  • angioimmunoblastic T-cell lymphoma anaplastic large cell lymphoma, ALK negative and anaplastic large cell lymphoma, ALK positive.
  • Plan for treatment with frontline multi-agent anthracycline containing chemotherapy for curative intent (for example, CHOP, CHOEP, EPOCH). A frontline therapy program can include different sequential phases of treatment, including high-dose therapy and autologous stem cell transplantation.
  • Availability of pre-treatment test specimen from bone marrow, blood, lymph node, or alternate site to identify tumor-specific clonotype, or willingness to undergo biopsy to identify the tumor-specific clonotype if tissue is not available at time of enrollment.
  • Able to understand and willing to sign an IRB approved written informed consent document.

Exclusion Criteria

  • Receiving second line of therapy or greater.
  • Diagnosis of primary cutaneous T-cell lymphoma, extranodal NK-cell lymphoma, acute T-cell lymphoma/leukemia, hepatosplenic T-cell lymphoma.

Gender

All

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (15)

Study Location Distance Name Phone Email
Dana Farber Cancer Institute - Boston, Massachusetts 2.4 miles Eric D Jacobsen MD 617-582-9086 eric_jacobsen@dfci.harvard.edu
Dana Farber Cancer Institute - Boston, Massachusetts 2.4 miles Eric D Jacobsen MD 617-582-9086 eric_jacobsen@dfci.harvard.edu
Dana Farber Cancer Institute - Boston, Massachusetts 2.4 miles Eric D Jacobsen MD 617-582-9086 eric_jacobsen@dfci.harvard.edu
Dana Farber Cancer Institute - Boston, Massachusetts 2.4 miles Eric D Jacobsen MD 617-582-9086 eric_jacobsen@dfci.harvard.edu
Dana Farber Cancer Institute - Boston, Massachusetts 2.4 miles Eric D Jacobsen MD 617-582-9086 eric_jacobsen@dfci.harvard.edu
Memorial Sloan Kettering Cancer Center - New York, New York 187.1 miles Steven Horwitz MD 212-639-3045 None
Memorial Sloan Kettering Cancer Center - New York, New York 187.1 miles Steven Horwitz MD 212-639-3045 None
Memorial Sloan Kettering Cancer Center - New York, New York 187.1 miles Steven Horwitz MD 212-639-3045 None
Memorial Sloan Kettering Cancer Center - New York, New York 187.1 miles Steven Horwitz MD 212-639-3045 None
Memorial Sloan Kettering Cancer Center - New York, New York 187.1 miles Steven Horwitz MD 212-639-3045 None
Washington University School of Medicine - Saint Louis, Missouri 1,039.5 miles Neha MehtaShah MD 314-273-1070 mehta-n@wustl.edu
Washington University School of Medicine - Saint Louis, Missouri 1,039.5 miles Neha MehtaShah MD 314-273-1070 mehta-n@wustl.edu
Washington University School of Medicine - Saint Louis, Missouri 1,039.5 miles Neha MehtaShah MD 314-273-1070 mehta-n@wustl.edu
Washington University School of Medicine - Saint Louis, Missouri 1,039.5 miles Neha MehtaShah MD 314-273-1070 mehta-n@wustl.edu
Washington University School of Medicine - Saint Louis, Missouri 1,039.5 miles Neha MehtaShah MD 314-273-1070 mehta-n@wustl.edu

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