Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury

Description

Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes. A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury. This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.

Study Start Date

October, 25 2017

Estimated Completion Date

August 2019

Interventions

  • Other: Discarded urine sample

Study ID

Boston Children’s Hospital -- IRB-P00025852

Status

Recruiting

Trial ID

NCT03263325

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

250

Sponsor

Boston Children’s Hospital

Inclusion Criteria

  • less than or equal to 8 years of age
  • scheduled for cardiac surgery

Exclusion Criteria

  • severe pre-existing renal insufficiency

Gender

All

Ages

8 Years and younger

Accepts Healthy Volunteers

No

Study Locations and Contact Information (5)

Study Location Distance Name Phone Email
Boston Childrens Hospital - Boston, Massachusetts 2.6 miles Douglas Atkinson MD 617-355-6225 douglas.atkinson@childrens.harvard.edu
Boston Childrens Hospital - Boston, Massachusetts 2.6 miles Douglas Atkinson MD 617-355-6225 douglas.atkinson@childrens.harvard.edu
Boston Childrens Hospital - Boston, Massachusetts 2.6 miles Douglas Atkinson MD 617-355-6225 douglas.atkinson@childrens.harvard.edu
Boston Childrens Hospital - Boston, Massachusetts 2.6 miles Douglas Atkinson MD 617-355-6225 douglas.atkinson@childrens.harvard.edu
Boston Childrens Hospital - Boston, Massachusetts 2.6 miles Douglas Atkinson MD 617-355-6225 douglas.atkinson@childrens.harvard.edu

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