Measurement of Renal Functional Reserve

Description

Single arm physiological study to measure renal functional reserve as a biomarker of kidney function and health

Study Start Date

July, 12 2017

Estimated Completion Date

June 2019

Interventions

  • Dietary Supplement: Ingestion of protein

Study ID

Brigham and Women's Hospital -- 2016P002287

Status

Unknown

Trial ID

NCT03190070

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

30

Sponsor

Brigham and Women's Hospital

Inclusion Criteria

    1. Age ?18 2. Estimated GFR >30 mL/min/1.73m2

Exclusion Criteria

    1. Allergy to iothalamate, shellfish or iodine 2. Use of metformin or amiodarone 3. Inability to maintain a stable regimen of medications which affect GFR for > one week prior to participation (e.g. non-steroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers) 4. Use of medications which directly affect elimination of creatinine (e.g. cimetidine and trimethoprim) 5. Acute exacerbation of asthma or chronic obstructive pulmonary disease within 3 months requiring hospitalization or oral steroid therapy 6. Inadequate intravenous access 7. Severe anemia (Hct <21%) 8. Acute kidney injury (rise in creatinine to ?1.5 times the previous baseline or by ? 0.3 mg/dL on most recent labs prior to enrollment) 9. History of contrast-induced nephropathy 10. Hyperthyroidism 11. Pheochromocytoma 12. Sickle cell disease 13. Urinary retention or incontinence 14. Status post organ transplant 15. Pregnancy or active breast feeding 16. Cognitive impairment with inability to give consent 17. Institutionalized status

Gender

All

Ages

18 Years and older

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (4)

Study Location Distance Name Phone Email
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None

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