Re-Evaluation of Systemic Early Neuromuscular Blockade and Transthoracic Ultrasound Assessment of the Diaphragm

Description

ROSETTA is a multi-centre study evaluating the time course of diaphragm thickness and function following exposure to neuromuscular blockade or control in patients with acute respiratory distress. ROSETTA is an ancillary study to the Re-evaluation of Systemic Early Neuromuscular Blockade (ROSE) trial (NCT02509078). It is designed to (1) test the feasibility of a multi-center evaluation of the diaphragm structure and function by ultrasound during mechanical ventilation and (2) determine whether neuromuscular blockade accelerates atrophy and dysfunction of the diaphragm in patients with acute respiratory distress syndrome (ARDS).

Study Start Date

October, 12 2017

Estimated Completion Date

December 2019

Interventions

No interventions cited

Study ID

University Health Network, Toronto -- 16-6360

Status

Unknown

Trial ID

NCT03132896

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

180

Sponsor

University Health Network, Toronto

Inclusion Criteria

    1. Patients enrolled in the ROSE PETAL trial (adult patients with moderate-severe acute respiratory distress syndrome who have received invasive mechanical ventilation for less than 5 days)

Exclusion Criteria

    1. Patients expected to be extubated within 24 hours of screening for eligibility 2. Patients with a contraindication to chest ultrasonography (chest tubes inserted over right lower chest wall chest wall trauma)

Gender

All

Ages

19 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (17)

Study Location Distance Name Phone Email
Brigham and Womens Health - Boston, Massachusetts 2.6 miles Israelyan Arman None aisraelyan@partners.org
Brigham and Womens Health - Boston, Massachusetts 2.6 miles Israelyan Arman None aisraelyan@partners.org
Brigham and Womens Health - Boston, Massachusetts 2.6 miles Israelyan Arman None aisraelyan@partners.org
Brigham and Womens Health - Boston, Massachusetts 2.6 miles Israelyan Arman None aisraelyan@partners.org
Baystate Health - Springfield, Massachusetts 78.9 miles Lesley De Souza None Lesley.DeSouza@baystatehealth.org
Cleveland Clinic - Cleveland, Ohio 544.9 miles Jim Bindas None bindasj@cccf.org
The Ohio State University Wexner Medical Center - Columbus, Ohio 641.8 miles Michael Pratts MD None Michael.Prats@osumc.edu
The Ohio State University Wexner Medical Center - Columbus, Ohio 641.8 miles Michael Pratts MD None Michael.Prats@osumc.edu
The Ohio State University Wexner Medical Center - Columbus, Ohio 641.8 miles Michael Pratts MD None Michael.Prats@osumc.edu
The Ohio State University Wexner Medical Center - Columbus, Ohio 641.8 miles Michael Pratts MD None Michael.Prats@osumc.edu
Vanderbilt University - Nashville, Tennessee 944.2 miles Margaret Hays None margaret.hays@Vanderbilt.Edu
Vanderbilt University - Nashville, Tennessee 944.2 miles Margaret Hays None margaret.hays@Vanderbilt.Edu
Vanderbilt University - Nashville, Tennessee 944.2 miles Margaret Hays None margaret.hays@Vanderbilt.Edu
Oregon Health Science University - Portland, Oregon 2,538.3 miles Steven Haberkorn None haberkor@ohsu.edu
Oregon Health Science University - Portland, Oregon 2,538.3 miles Steven Haberkorn None haberkor@ohsu.edu
Oregon Health Science University - Portland, Oregon 2,538.3 miles Steven Haberkorn None haberkor@ohsu.edu
Oregon Health Science University - Portland, Oregon 2,538.3 miles Steven Haberkorn None haberkor@ohsu.edu

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