A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis.

Description

A Phase 3, randomized, double-masked, vehicle-controlled trial to evaluate the safety and efficacy of ADX-102 ophthalmic solution in Subjects with non-infectious anterior-uveitis.

Study Start Date

April, 26 2017

Estimated Completion Date

December 2018

Interventions

  • Drug: ADX-102 Ophthalmic Solution (0.5%)
  • Drug: Vehicle of ADX-102 Ophthalmic Solution

Study ID

Aldeyra Therapeutics, Inc. -- ADX-102-UV-005

Status

Recruiting

Trial ID

NCT03131154

Study Type

Interventional

Trial Phase

Phase 3

Enrollment Quota

100

Sponsor

Aldeyra Therapeutics, Inc.

Inclusion Criteria

  • Male or female subjects aged ? 18 years and ? 85 years.
  • Subjects with acute non-infectious anterior uveitis with onset of symptoms within the previous 2 weeks.
  • Best corrected visual acuity (BCVA) better than or equal to 35 letters in the study eye and 65 letters in the non-study eye using ETDRS testing.

Exclusion Criteria

  • Have severe/serious ocular pathology in the study eye(s) which may preclude study completion, in the judgement of the Investigator.
  • Active intermediate or posterior uveitis in the study eye(s).
  • Previous anterior uveitis episode in the study eye ? 4 weeks prior to screening.
  • Have participated in another investigational device or drug study within 30 days prior to screening.
  • Participation in a prior ADX-102 study.

Gender

All

Ages

18 Years to 85 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (100)

Study Location Distance Name Phone Email
Ophthalmic Consultants of Boston - Boston, Massachusetts 2.8 miles Lana Rifkin MD None None
Ophthalmic Consultants of Boston - Boston, Massachusetts 2.8 miles Lana Rifkin MD None None
Ophthalmic Consultants of Boston - Boston, Massachusetts 2.8 miles Lana Rifkin MD None None
Ophthalmic Consultants of Boston - Boston, Massachusetts 2.8 miles Lana Rifkin MD None None
Ocular Immunology Uveitis Foundation - Waltham, Massachusetts 4.7 miles Stephen Foster MD None None
Ocular Immunology Uveitis Foundation - Waltham, Massachusetts 4.7 miles Stephen Foster MD None None
Ocular Immunology Uveitis Foundation - Waltham, Massachusetts 4.7 miles Stephen Foster MD None None
Ocular Immunology Uveitis Foundation - Waltham, Massachusetts 4.7 miles Stephen Foster MD None None
Valley Eye Physicians Surgeons - Ayer, Massachusetts 27.8 miles Gisela Velez MD None None
Valley Eye Physicians Surgeons - Ayer, Massachusetts 27.8 miles Gisela Velez MD None None
Valley Eye Physicians Surgeons - Ayer, Massachusetts 27.8 miles Gisela Velez MD None None
Valley Eye Physicians Surgeons - Ayer, Massachusetts 27.8 miles Gisela Velez MD None None
Danbury Eye Physicians Surgeons - Danbury, Connecticut 139.0 miles Matthew Paul MD None None
Danbury Eye Physicians Surgeons - Danbury, Connecticut 139.0 miles Matthew Paul MD None None
Danbury Eye Physicians Surgeons - Danbury, Connecticut 139.0 miles Matthew Paul MD None None
Danbury Eye Physicians Surgeons - Danbury, Connecticut 139.0 miles Matthew Paul MD None None
Metropolitan Eye Research and Surgery Institute - Palisades Park, New Jersey 183.0 miles David Chu MD None None
Metropolitan Eye Research and Surgery Institute - Palisades Park, New Jersey 183.0 miles David Chu MD None None
Metropolitan Eye Research and Surgery Institute - Palisades Park, New Jersey 183.0 miles David Chu MD None None
Metropolitan Eye Research and Surgery Institute - Palisades Park, New Jersey 183.0 miles David Chu MD None None
Virginia Eye Consultants - Norfolk, Virginia 468.9 miles John Sheppard MD None None
Virginia Eye Consultants - Norfolk, Virginia 468.9 miles John Sheppard MD None None
Virginia Eye Consultants - Norfolk, Virginia 468.9 miles John Sheppard MD None None
Virginia Eye Consultants - Norfolk, Virginia 468.9 miles John Sheppard MD None None
Oakland Ophthalmic Surgery - Birmingham, Michigan 618.5 miles Maria Jancevski MD None None
Oakland Ophthalmic Surgery - Birmingham, Michigan 618.5 miles Maria Jancevski MD None None
Oakland Ophthalmic Surgery - Birmingham, Michigan 618.5 miles Maria Jancevski MD None None
Oakland Ophthalmic Surgery - Birmingham, Michigan 618.5 miles Maria Jancevski MD None None
Midwest Eye Institute - Indianapolis, Indiana 804.6 miles Milan Shah MD None None
Midwest Eye Institute - Indianapolis, Indiana 804.6 miles Milan Shah MD None None
Midwest Eye Institute - Indianapolis, Indiana 804.6 miles Milan Shah MD None None
Midwest Eye Institute - Indianapolis, Indiana 804.6 miles Milan Shah MD None None
UAB Department of Ophthalmology - Birmingham, Alabama 1,051.7 miles Russell Read MD None None
UAB Department of Ophthalmology - Birmingham, Alabama 1,051.7 miles Russell Read MD None None
UAB Department of Ophthalmology - Birmingham, Alabama 1,051.7 miles Russell Read MD None None
UAB Department of Ophthalmology - Birmingham, Alabama 1,051.7 miles Russell Read MD None None
Center for Retina and Macular Disease - Winter Haven, Florida 1,161.3 miles Richard Hamilton MD None None
Center for Retina and Macular Disease - Winter Haven, Florida 1,161.3 miles Richard Hamilton MD None None
Center for Retina and Macular Disease - Winter Haven, Florida 1,161.3 miles Richard Hamilton MD None None
Center for Retina and Macular Disease - Winter Haven, Florida 1,161.3 miles Richard Hamilton MD None None
Tauber Eye Center - Kansas City, Missouri 1,250.3 miles Joseph Tauber MD None None
Tauber Eye Center - Kansas City, Missouri 1,250.3 miles Joseph Tauber MD None None
Tauber Eye Center - Kansas City, Missouri 1,250.3 miles Joseph Tauber MD None None
Tauber Eye Center - Kansas City, Missouri 1,250.3 miles Joseph Tauber MD None None
Levenson Eye Associates - Jacksonville, Florida 1,260.3 miles Frank McDonald MD None None
Levenson Eye Associates - Jacksonville, Florida 1,260.3 miles Frank McDonald MD None None
Levenson Eye Associates - Jacksonville, Florida 1,260.3 miles Frank McDonald MD None None
Levenson Eye Associates - Jacksonville, Florida 1,260.3 miles Frank McDonald MD None None
Bergstrom Eye Research - Fargo, North Dakota 1,299.2 miles Lance Bergstrom MD None None
Bergstrom Eye Research - Fargo, North Dakota 1,299.2 miles Lance Bergstrom MD None None
Bergstrom Eye Research - Fargo, North Dakota 1,299.2 miles Lance Bergstrom MD None None
Bergstrom Eye Research - Fargo, North Dakota 1,299.2 miles Lance Bergstrom MD None None
Texas Retina Associates - Dallas, Texas 1,545.0 miles Robert Wang MD None None
Texas Retina Associates - Dallas, Texas 1,545.0 miles Robert Wang MD None None
Texas Retina Associates - Dallas, Texas 1,545.0 miles Robert Wang MD None None
Texas Retina Associates - Dallas, Texas 1,545.0 miles Robert Wang MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Rosa Kim MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Christopher Henry MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Rosa Kim MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Christopher Henry MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Rosa Kim MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Christopher Henry MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Rosa Kim MD None None
Retina Consultants of Houston - Houston, Texas 1,609.9 miles Christopher Henry MD None None
Retina and Uveitis Consultants of Texas - San Antonio, Texas 1,769.8 miles David Scales MD None None
Retina and Uveitis Consultants of Texas - San Antonio, Texas 1,769.8 miles David Scales MD None None
Retina and Uveitis Consultants of Texas - San Antonio, Texas 1,769.8 miles David Scales MD None None
Retina and Uveitis Consultants of Texas - San Antonio, Texas 1,769.8 miles David Scales MD None None
Corneal Consultants of Colorado - Littleton, Colorado 1,771.5 miles S Lance Forstot MD None None
Corneal Consultants of Colorado - Littleton, Colorado 1,771.5 miles S Lance Forstot MD None None
Corneal Consultants of Colorado - Littleton, Colorado 1,771.5 miles S Lance Forstot MD None None
Corneal Consultants of Colorado - Littleton, Colorado 1,771.5 miles S Lance Forstot MD None None
MM Eye Institute - Prescott, Arizona 2,283.9 miles Scott Markham MD None None
MM Eye Institute - Prescott, Arizona 2,283.9 miles Scott Markham MD None None
MM Eye Institute - Prescott, Arizona 2,283.9 miles Scott Markham MD None None
MM Eye Institute - Prescott, Arizona 2,283.9 miles Scott Markham MD None None
Retinal Research Institute - Phoenix, Arizona 2,295.9 miles Pravin Dugel MD None None
Byers Eye Institute at Stanford University - Palo Alto, California 2,295.9 miles Diana Do MD None None
Byers Eye Institute at Stanford University - Palo Alto, California 2,295.9 miles Diana Do MD None None
Byers Eye Institute at Stanford University - Palo Alto, California 2,295.9 miles Diana Do MD None None
Retinal Research Institute - Phoenix, Arizona 2,295.9 miles Pravin Dugel MD None None
Retinal Research Institute - Phoenix, Arizona 2,295.9 miles Pravin Dugel MD None None
Retinal Research Institute - Phoenix, Arizona 2,295.9 miles Pravin Dugel MD None None
Byers Eye Institute at Stanford University - Palo Alto, California 2,295.9 miles Diana Do MD None None
Walman Eye Center - Sun City, Arizona 2,304.3 miles Gerald Walman MD None None
Walman Eye Center - Sun City, Arizona 2,304.3 miles Gerald Walman MD None None
Walman Eye Center - Sun City, Arizona 2,304.3 miles Gerald Walman MD None None
Walman Eye Center - Sun City, Arizona 2,304.3 miles Gerald Walman MD None None
Oregon Retina LLP - Eugene, Oregon 2,581.7 miles Albert Edwards MD None None
Oregon Retina LLP - Eugene, Oregon 2,581.7 miles Albert Edwards MD None None
Oregon Retina LLP - Eugene, Oregon 2,581.7 miles Albert Edwards MD None None
Oregon Retina LLP - Eugene, Oregon 2,581.7 miles Albert Edwards MD None None
RetinaVitreous Associates Medical Group - Beverly Hills, California 2,601.9 miles Pouya Dayani MD None None
RetinaVitreous Associates Medical Group - Beverly Hills, California 2,601.9 miles Pouya Dayani MD None None
RetinaVitreous Associates Medical Group - Beverly Hills, California 2,601.9 miles Pouya Dayani MD None None
RetinaVitreous Associates Medical Group - Beverly Hills, California 2,601.9 miles Pouya Dayani MD None None
Retinal Consultants Medical Group Inc - Sacramento, California 2,627.0 miles Brian Reed MD None None
Retinal Consultants Medical Group Inc - Sacramento, California 2,627.0 miles Brian Reed MD None None
Retinal Consultants Medical Group Inc - Sacramento, California 2,627.0 miles Brian Reed MD None None
Retinal Consultants Medical Group Inc - Sacramento, California 2,627.0 miles Brian Reed MD None None

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