Efficacy and Safety of Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

Description

The aim of the current study is to investigate the efficacy and safety of nintedanib over 52 weeks in patients with Progressive Fibrosing Interstitial Lung Disease (PF-ILD) defined as patients who present with features of diffuse fibrosing lung disease of >10% extent on high-resolution computed tomography (HRCT) and whose lung function and respiratory symptoms or chest imaging have worsened despite treatment with unapproved medications used in clinical practice to treat ILD. There is currently no efficacious treatment available for PF-ILD. Based on its efficacy and safety in Idiopatic Pulmonary Fibrosis (IPF), it is anticipated that Nintedanib will be a new treatment option for patients with PF-ILD.

Study Start Date

January, 17 2017

Estimated Completion Date

November 2019

Interventions

  • Drug: Placebo
  • Drug: Nintedanib

Study ID

Boehringer Ingelheim -- 1199.247

Status

Recruiting

Trial ID

NCT02999178

Study Type

Interventional

Trial Phase

Phase 3

Enrollment Quota

600

Sponsor

Boehringer Ingelheim

Inclusion criteria:
  • Written Informed Consent consistent with International Conference on Harmonisation Harmonised Tripartite Guideline for Good Clinical Practice (ICH-GCP) and local laws signed prior to entry into the study (and prior to any study procedure including shipment of High Resolution Computer Tomography (HRCT) to reviewer).
  • Male or female patients aged >= 18 years at Visit 1.
  • Patients with physician diagnosed Interstitial Lung Disease (ILD) who fulfil at least one of the following criteria for Progressive Fibrosing Interstitial Lung Disease (PF-ILD) within 24 months of screening visit (Visit 1) despite treatment with unapproved medications used in clinical practice to treat ILD, as assessed by the investigator (refer to Exclusion Criteria):
  • Clinically significant decline in Forced Vital Capacity (FVC) % pred based on a relative decline of >=10%
  • Marginal decline in FVC % pred based on a relative decline of .>=5-<10% combined with worsening of respiratory symptoms
  • Marginal decline in FVC % pred based on a relative decline of >=5-<10% combined with increasing extent of fibrotic changes on chest imaging
  • Worsening of respiratory symptoms as well as increasing extent of fibrotic changes on chest imaging [Note: Changes attributable to comorbidities e.g. infection, heart failure must be excluded. Unapproved medications used in the clinical practice to treat ILD include but are not limited to corticosteroid, azathioprine, mycophenolate mofetil (MMF), n-acetylcysteine (NAC), rituximab, cyclophosphamide, cyclosporine, tacrolimus].
  • Fibrosing lung disease on HRCT, defined as reticular abnormality with traction bronchiectasis with or without honeycombing, with disease extent of >10%, performed within 12 months of Visit 1 as confirmed by central readers.
  • For patients with underlying Connective Tissue Disease (CTD): stable CTD as defined by no initiation of new therapy or withdrawal of therapy for CTD within 6 weeks prior to Visit 1.
  • Carbon Monoxide Diffusion Capacity (DLCO) corrected for Haemoglobin (Hb) [visit 1] ? 30% and <80% predicted of normal at Visit 2
  • FVC >= 45% predicted at Visit 2 Exclusion criteria:
  • Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) > 1.5 x Upper Limit of Normal (ULN) at Visit 1
  • Bilirubin > 1.5 x ULN at Visit 1
  • Creatinine clearance <30 mL/min calculated by Cockcroft-Gault formula at Visit 1 [Note: Laboratory parameters from Visit 1 have to satisfy the laboratory threshold values as shown above. Visit 2 laboratory results will be available only after randomization. In case at Visit 2 the results do no longer satisfy the entry criteria, the Investigator has to decide whether it is justified that the patient remains on study drug. The justification for decision needs to be documented. Laboratory parameters that are found to be abnormal at Visit 1 are allowed to be re-tested (once) if it is thought to be a measurement error (i.e. there was no abnormal result of this test in the recent history of the patient and there is no related clinical sign) or the result of a temporary and reversible medical condition, once that condition is resolved].
  • Patients with underlying chronic liver disease (Child Pugh A, B or C hepatic impairment).
  • Previous treatment with nintedanib or pirfenidone.
  • Other investigational therapy received within 1 month or 6 half-lives (whichever was greater) prior to screening visit (Visit 1).
  • Use of any of the following medications for the treatment of Interstitial Lung Disease (ILD): azathioprine (AZA), cyclosporine, MMF, tacrolimus, oral corticosteroids (OCS) >20mg/day and the combination of OCS+AZA+NAC within 4 weeks of Visit 2, cyclophosphamide within 8 weeks of Visit 2, rituximab within 6 months of Visit 2. Note: Patients whose Rheumatoid Arthritis (RA)/Connective Tissue Disease (CTD) is managed by these medications should not be considered for participation in the current study unless change in RA/CTD medication is medically indicated (see Inclusion Criteria)
  • Diagnosis of Idiopathic Pulmonary Fibrosis (IPF) based on American Thoracic Society (ATS)/ European Respiratory Society (ERS)/Japanese Respiratory Society (JRS)/Latin American Thoracic Association (ALAT) 2011 Guidelines.
  • Significant Pulmonary Arterial Hypertension (PAH) defined by any of the following:
  • Previous clinical or echocardiographic evidence of significant right heart failure
  • History of right heart catheterization showing a cardiac index <= 2 l/min/m²
  • PAH requiring parenteral therapy with epoprostenol/treprostinil
  • Primary obstructive airway physiology (pre-bronchodilator FEV1/FVC < 0.7 at Visit 1).
  • In the opinion of the Investigator, other clinically significant pulmonary abnormalities.
  • Major extrapulmonary physiological restriction (e.g. chest wall abnormality, large pleural effusion)
  • Cardiovascular diseases, any of the following:
  • Severe hypertension, uncontrolled under treatment (?160/100 mmHg), within 6 month of Visit 1
  • Myocardial infarction within 6 months of Visit 1
  • Unstable cardiac angina within 6 months of Visit 1
  • Bleeding risk, any of the following:
  • Known genetic predisposition to bleeding.
  • Patients who require
  • Fibrinolysis, full-dose therapeutic anticoagulation (e.g. vitamin K antagonists, direct thrombin inhibitors, heparin, hirudin)
  • High dose antiplatelet therapy. [Note: Prophylactic low dose heparin or heparin flush as needed for maintenance of an indwelling intravenous device (e.g. enoxaparin 4000 I.U. s.c. per day), as well as prophylactic use of antiplatelet therapy (e.g. acetyl salicylic acid up to 325 mg/day, or clopidogrel at 75 mg/day, or equivalent doses of other antiplatelet therapy) are not prohibited].
  • History of haemorrhagic central nervous system (CNS) event within 12 months of Visit 1.
  • Any of the following within 3 months of Visit 1:
  • Haemoptysis or haematuria
  • Active gastro-intestinal (GI) bleeding or GI
  • ulcers
  • Major injury or surgery (Investigators judgment).
  • Coagulation parameters: International normalized ratio (INR) >2, prolongation of prothrombin time (PT) and activated partial thromboplastin time (aPTT) by >1.5 x ULN at Visit 1.
  • History of thrombotic event (including stroke and transient ischemic attack) within 12 months of Visit 1.
  • Known hypersensitivity to the trial medication or its components (i.e. soya lecithin)
  • Patients with peanut allergy.
  • Other disease that may interfere with testing procedures or in the judgment of the Investigator may interfere with trial participation or may put the patient at risk when participating in this trial.
  • Life expectancy for disease other than ILD < 2.5 years (Investigator assessment).
  • Planned major surgical procedures.
  • Women who are pregnant, nursing, or who plan to become pregnant while in the trial.
  • Women of childbearing potential* not willing or able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly as well as one barrier method for 28 days prior to and 3 months after nintedanib administration. A list of contraception methods meeting these criteria is provided in the patient information.
  • In the opinion of the Investigator, active alcohol or drug abuse.
  • Patients not able to understand or follow trial procedures including completion of self-administered questionnaires without help. *A woman is considered of childbearing potential, i.e. fertile, following menarche and until becoming post-menopausal unless permanently sterile. Permanent sterilisation methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy.
  • Gender

    All

    Ages

    18 Years and older

    Accepts Healthy Volunteers

    No

    Study Locations and Contact Information (217)

    Study Location Distance Name Phone Email
    Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.4 miles None None None
    Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.4 miles None None None
    Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.4 miles None None None
    Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.4 miles None None None
    Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.4 miles None None None
    Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
    Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
    Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
    Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
    Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
    DartmouthHitchcock Medical Center - Lebanon, New Hampshire 105.5 miles None None None
    DartmouthHitchcock Medical Center - Lebanon, New Hampshire 105.5 miles None None None
    DartmouthHitchcock Medical Center - Lebanon, New Hampshire 105.5 miles None None None
    DartmouthHitchcock Medical Center - Lebanon, New Hampshire 105.5 miles None None None
    DartmouthHitchcock Medical Center - Lebanon, New Hampshire 105.5 miles None None None
    Pulmonary and Sleep Specialists - Danbury, Connecticut 139.0 miles None None None
    Ichan School of Medicine at Mount Sinai - New York, New York 183.2 miles None None None
    Ichan School of Medicine at Mount Sinai - New York, New York 183.2 miles None None None
    Ichan School of Medicine at Mount Sinai - New York, New York 183.2 miles None None None
    Ichan School of Medicine at Mount Sinai - New York, New York 183.2 miles None None None
    Ichan School of Medicine at Mount Sinai - New York, New York 183.2 miles None None None
    NewYorkPresbyterianWeill Cornell Medical Center - New York, New York 187.1 miles None None None
    NewYorkPresbyterianWeill Cornell Medical Center - New York, New York 187.1 miles None None None
    NewYorkPresbyterianWeill Cornell Medical Center - New York, New York 187.1 miles None None None
    NewYorkPresbyterianWeill Cornell Medical Center - New York, New York 187.1 miles None None None
    NewYorkPresbyterianWeill Cornell Medical Center - New York, New York 187.1 miles None None None
    Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
    Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
    Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
    Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
    Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
    University of Pennsylvania - Philadelphia, Pennsylvania 270.8 miles None None None
    University of Pennsylvania - Philadelphia, Pennsylvania 270.8 miles None None None
    University of Pennsylvania - Philadelphia, Pennsylvania 270.8 miles None None None
    University of Pennsylvania - Philadelphia, Pennsylvania 270.8 miles None None None
    University of Pennsylvania - Philadelphia, Pennsylvania 270.8 miles None None None
    Temple Lung Center at Oaks - Phoenixville, Pennsylvania 279.0 miles None None None
    Temple Lung Center at Oaks - Phoenixville, Pennsylvania 279.0 miles None None None
    Temple Lung Center at Oaks - Phoenixville, Pennsylvania 279.0 miles None None None
    Temple Lung Center at Oaks - Phoenixville, Pennsylvania 279.0 miles None None None
    Temple Lung Center at Oaks - Phoenixville, Pennsylvania 279.0 miles None None None
    Penn State Milton S Hershey Medical Center - Hershey, Pennsylvania 321.7 miles None None None
    Penn State Milton S Hershey Medical Center - Hershey, Pennsylvania 321.7 miles None None None
    Penn State Milton S Hershey Medical Center - Hershey, Pennsylvania 321.7 miles None None None
    Penn State Milton S Hershey Medical Center - Hershey, Pennsylvania 321.7 miles None None None
    Penn State Milton S Hershey Medical Center - Hershey, Pennsylvania 321.7 miles None None None
    Pulmonary and Critical Care Associates of Baltimore - Towson, Maryland 352.4 miles None None None
    Pulmonary and Critical Care Associates of Baltimore - Towson, Maryland 352.4 miles None None None
    Pulmonary and Critical Care Associates of Baltimore - Towson, Maryland 352.4 miles None None None
    Pulmonary and Critical Care Associates of Baltimore - Towson, Maryland 352.4 miles None None None
    Pulmonary and Critical Care Associates of Baltimore - Towson, Maryland 352.4 miles None None None
    Johns Hopkins Asthma and Allergy Center - Baltimore, Maryland 356.0 miles None None None
    Johns Hopkins Asthma and Allergy Center - Baltimore, Maryland 356.0 miles None None None
    Johns Hopkins Asthma and Allergy Center - Baltimore, Maryland 356.0 miles None None None
    Johns Hopkins Asthma and Allergy Center - Baltimore, Maryland 356.0 miles None None None
    Johns Hopkins Asthma and Allergy Center - Baltimore, Maryland 356.0 miles None None None
    University of Maryland School of Medicine - Baltimore, Maryland 358.9 miles None None None
    Inova Fairfax Medical Campus - Falls Church, Virginia 401.4 miles None None None
    Inova Fairfax Medical Campus - Falls Church, Virginia 401.4 miles None None None
    Inova Fairfax Medical Campus - Falls Church, Virginia 401.4 miles None None None
    Inova Fairfax Medical Campus - Falls Church, Virginia 401.4 miles None None None
    Inova Fairfax Medical Campus - Falls Church, Virginia 401.4 miles None None None
    Pulmonary Associates of Richmond Inc - Richmond, Virginia 475.4 miles None None None
    Pulmonary Associates of Richmond Inc - Richmond, Virginia 475.4 miles None None None
    Pulmonary Associates of Richmond Inc - Richmond, Virginia 475.4 miles None None None
    Pulmonary Associates of Richmond Inc - Richmond, Virginia 475.4 miles None None None
    Pulmonary Associates of Richmond Inc - Richmond, Virginia 475.4 miles None None None
    University of Pittsburgh Medical Center - Pittsburgh, Pennsylvania 478.5 miles None None None
    University of Pittsburgh Medical Center - Pittsburgh, Pennsylvania 478.5 miles None None None
    University of Pittsburgh Medical Center - Pittsburgh, Pennsylvania 478.5 miles None None None
    University of Pittsburgh Medical Center - Pittsburgh, Pennsylvania 478.5 miles None None None
    University of Pittsburgh Medical Center - Pittsburgh, Pennsylvania 478.5 miles None None None
    Cleveland Clinic - Cleveland, Ohio 544.9 miles None None None
    Cleveland Clinic - Cleveland, Ohio 544.9 miles None None None
    Cleveland Clinic - Cleveland, Ohio 544.9 miles None None None
    Cleveland Clinic - Cleveland, Ohio 544.9 miles None None None
    Cleveland Clinic - Cleveland, Ohio 544.9 miles None None None
    Duke University Medical Center - Durham, North Carolina 609.0 miles None None None
    Duke University Medical Center - Durham, North Carolina 609.0 miles None None None
    Duke University Medical Center - Durham, North Carolina 609.0 miles None None None
    Duke University Medical Center - Durham, North Carolina 609.0 miles None None None
    Duke University Medical Center - Durham, North Carolina 609.0 miles None None None
    Henry Ford Health System - Detroit, Michigan 612.3 miles None None None
    Henry Ford Health System - Detroit, Michigan 612.3 miles None None None
    Henry Ford Health System - Detroit, Michigan 612.3 miles None None None
    Henry Ford Health System - Detroit, Michigan 612.3 miles None None None
    Henry Ford Health System - Detroit, Michigan 612.3 miles None None None
    Ohio State University - Columbus, Ohio 641.8 miles None None None
    Ohio State University - Columbus, Ohio 641.8 miles None None None
    Ohio State University - Columbus, Ohio 641.8 miles None None None
    Ohio State University - Columbus, Ohio 641.8 miles None None None
    Ohio State University - Columbus, Ohio 641.8 miles None None None
    Pulmonary and Critical Care Medicine - Ann Arbor, Michigan 645.2 miles None None None
    Pulmonary and Critical Care Medicine - Ann Arbor, Michigan 645.2 miles None None None
    Pulmonary and Critical Care Medicine - Ann Arbor, Michigan 645.2 miles None None None
    Pulmonary and Critical Care Medicine - Ann Arbor, Michigan 645.2 miles None None None
    Pulmonary and Critical Care Medicine - Ann Arbor, Michigan 645.2 miles None None None
    Southeastern Research Center - Winston-Salem, North Carolina 659.2 miles None None None
    Southeastern Research Center - Winston-Salem, North Carolina 659.2 miles None None None
    Southeastern Research Center - Winston-Salem, North Carolina 659.2 miles None None None
    Southeastern Research Center - Winston-Salem, North Carolina 659.2 miles None None None
    Southeastern Research Center - Winston-Salem, North Carolina 659.2 miles None None None
    Spectrum Health - Grand Rapids, Michigan 735.6 miles None None None
    Spectrum Health - Grand Rapids, Michigan 735.6 miles None None None
    Spectrum Health - Grand Rapids, Michigan 735.6 miles None None None
    Spectrum Health - Grand Rapids, Michigan 735.6 miles None None None
    Spectrum Health - Grand Rapids, Michigan 735.6 miles None None None
    University of Kentucky Medical Center - Lexington, Kentucky 769.1 miles None None None
    Baptist Health Lexington - Lexington, Kentucky 771.2 miles None None None
    Baptist Health Lexington - Lexington, Kentucky 771.2 miles None None None
    Baptist Health Lexington - Lexington, Kentucky 771.2 miles None None None
    Baptist Health Lexington - Lexington, Kentucky 771.2 miles None None None
    University of South Carolina - Columbia, South Carolina 786.3 miles None None None
    University of South Carolina - Columbia, South Carolina 786.3 miles None None None
    Medical University of South Carolina - Charleston, South Carolina 821.2 miles None None None
    Medical University of South Carolina - Charleston, South Carolina 821.2 miles None None None
    Medical University of South Carolina - Charleston, South Carolina 821.2 miles None None None
    Medical University of South Carolina - Charleston, South Carolina 821.2 miles None None None
    University of Louisville - Louisville, Kentucky 823.2 miles None None None
    University of Louisville - Louisville, Kentucky 823.2 miles None None None
    University of Louisville - Louisville, Kentucky 823.2 miles None None None
    University of Louisville - Louisville, Kentucky 823.2 miles None None None
    Northwestern University - Chicago, Illinois 847.9 miles None None None
    Northwestern University - Chicago, Illinois 847.9 miles None None None
    Northwestern University - Chicago, Illinois 847.9 miles None None None
    University of Chicago - Chicago, Illinois 848.0 miles None None None
    University of Chicago - Chicago, Illinois 848.0 miles None None None
    University of Chicago - Chicago, Illinois 848.0 miles None None None
    University of Chicago - Chicago, Illinois 848.0 miles None None None
    University of Chicago - Chicago, Illinois 848.0 miles None None None
    Loyola University Medical Center - Maywood, Illinois 859.6 miles None None None
    Loyola University Medical Center - Maywood, Illinois 859.6 miles None None None
    Loyola University Medical Center - Maywood, Illinois 859.6 miles None None None
    Loyola University Medical Center - Maywood, Illinois 859.6 miles None None None
    Loyola University Medical Center - Maywood, Illinois 859.6 miles None None None
    Emory University - Atlanta, Georgia 932.0 miles None None None
    Emory University - Atlanta, Georgia 932.0 miles None None None
    Emory University - Atlanta, Georgia 932.0 miles None None None
    University of Alabama at Birmingham - Birmingham, Alabama 1,052.1 miles None None None
    The Lung Research Center LLC - Chesterfield, Missouri 1,053.3 miles None None None
    The Lung Research Center LLC - Chesterfield, Missouri 1,053.3 miles None None None
    The Lung Research Center LLC - Chesterfield, Missouri 1,053.3 miles None None None
    The Lung Research Center LLC - Chesterfield, Missouri 1,053.3 miles None None None
    The Lung Research Center LLC - Chesterfield, Missouri 1,053.3 miles None None None
    University of Florida College of Medicine - Gainesville, Florida 1,081.3 miles None None None
    Mayo ClinicRochester - Rochester, Minnesota 1,083.1 miles None None None
    Mayo ClinicRochester - Rochester, Minnesota 1,083.1 miles None None None
    Mayo ClinicRochester - Rochester, Minnesota 1,083.1 miles None None None
    Mayo ClinicRochester - Rochester, Minnesota 1,083.1 miles None None None
    Mayo ClinicRochester - Rochester, Minnesota 1,083.1 miles None None None
    University of Minnesota Masonic Cancer Center - Minneapolis, Minnesota 1,120.0 miles None None None
    University of Minnesota Masonic Cancer Center - Minneapolis, Minnesota 1,120.0 miles None None None
    University of Minnesota Masonic Cancer Center - Minneapolis, Minnesota 1,120.0 miles None None None
    University of Minnesota Masonic Cancer Center - Minneapolis, Minnesota 1,120.0 miles None None None
    University of Minnesota Masonic Cancer Center - Minneapolis, Minnesota 1,120.0 miles None None None
    Pulmonary and Sleep of Tampa Bay - Brandon, Florida 1,182.6 miles None None None
    Univeristy of Kansas Medical Center - Kansas City, Kansas 1,251.3 miles None None None
    Univeristy of Kansas Medical Center - Kansas City, Kansas 1,251.3 miles None None None
    Univeristy of Kansas Medical Center - Kansas City, Kansas 1,251.3 miles None None None
    Univeristy of Kansas Medical Center - Kansas City, Kansas 1,251.3 miles None None None
    Univeristy of Kansas Medical Center - Kansas City, Kansas 1,251.3 miles None None None
    University of Miami - Miami, Florida 1,260.8 miles None None None
    University of Miami - Miami, Florida 1,260.8 miles None None None
    University of Miami - Miami, Florida 1,260.8 miles None None None
    Creighton University - Omaha, Nebraska 1,286.1 miles None None None
    Creighton University - Omaha, Nebraska 1,286.1 miles None None None
    Creighton University - Omaha, Nebraska 1,286.1 miles None None None
    Creighton University - Omaha, Nebraska 1,286.1 miles None None None
    Creighton University - Omaha, Nebraska 1,286.1 miles None None None
    University of Texas Southwestern Medical Center - Dallas, Texas 1,543.9 miles None None None
    University of Texas Southwestern Medical Center - Dallas, Texas 1,543.9 miles None None None
    University of Texas Southwestern Medical Center - Dallas, Texas 1,543.9 miles None None None
    University of Texas Southwestern Medical Center - Dallas, Texas 1,543.9 miles None None None
    University of Texas Southwestern Medical Center - Dallas, Texas 1,543.9 miles None None None
    Baylor University Medical Center - Dallas, Texas 1,549.2 miles None None None
    Baylor University Medical Center - Dallas, Texas 1,549.2 miles None None None
    Baylor University Medical Center - Dallas, Texas 1,549.2 miles None None None
    Baylor University Medical Center - Dallas, Texas 1,549.2 miles None None None
    Baylor University Medical Center - Dallas, Texas 1,549.2 miles None None None
    Texas Pul ampamp Crit Care Conslt - Fort Worth, Texas 1,578.4 miles None None None
    Texas Pul ampamp Crit Care Conslt - Fort Worth, Texas 1,578.4 miles None None None
    Texas Pul ampamp Crit Care Conslt - Fort Worth, Texas 1,578.4 miles None None None
    Texas Pul ampamp Crit Care Conslt - Fort Worth, Texas 1,578.4 miles None None None
    Texas Pul ampamp Crit Care Conslt - Fort Worth, Texas 1,578.4 miles None None None
    Houston Methodist Hospital - Houston, Texas 1,609.9 miles None None None
    Houston Methodist Hospital - Houston, Texas 1,609.9 miles None None None
    Houston Methodist Hospital - Houston, Texas 1,609.9 miles None None None
    Houston Methodist Hospital - Houston, Texas 1,609.9 miles None None None
    Houston Methodist Hospital - Houston, Texas 1,609.9 miles None None None
    National Jewish Health - Denver, Colorado 1,766.1 miles None None None
    Medical Arts and Research Center MARC - San Antonio, Texas 1,768.2 miles None None None
    Diagnostics Research Group - San Antonio, Texas 1,768.2 miles None None None
    Medical Arts and Research Center MARC - San Antonio, Texas 1,768.2 miles None None None
    Diagnostics Research Group - San Antonio, Texas 1,768.2 miles None None None
    Diagnostics Research Group - San Antonio, Texas 1,768.2 miles None None None
    Medical Arts and Research Center MARC - San Antonio, Texas 1,768.2 miles None None None
    Diagnostics Research Group - San Antonio, Texas 1,768.2 miles None None None
    Medical Arts and Research Center MARC - San Antonio, Texas 1,768.2 miles None None None
    Medical Arts and Research Center MARC - San Antonio, Texas 1,768.2 miles None None None
    Diagnostics Research Group - San Antonio, Texas 1,768.2 miles None None None
    University of Utah Health Sciences Center - Salt Lake City, Utah 2,093.0 miles None None None
    University of Utah Health Sciences Center - Salt Lake City, Utah 2,093.0 miles None None None
    University of Utah Health Sciences Center - Salt Lake City, Utah 2,093.0 miles None None None
    University of Utah Health Sciences Center - Salt Lake City, Utah 2,093.0 miles None None None
    University of Utah Health Sciences Center - Salt Lake City, Utah 2,093.0 miles None None None
    University of Arizona - Tucson, Arizona 2,281.0 miles None None None
    The Oregon Clinic - Portland, Oregon 2,531.2 miles None None None
    The Oregon Clinic - Portland, Oregon 2,531.2 miles None None None
    The Oregon Clinic - Portland, Oregon 2,531.2 miles None None None
    The Oregon Clinic - Portland, Oregon 2,531.2 miles None None None
    The Oregon Clinic - Portland, Oregon 2,531.2 miles None None None
    CedarsSinai Medical Center - Los Angeles, California 2,601.4 miles None None None
    CedarsSinai Medical Center - Los Angeles, California 2,601.4 miles None None None
    CedarsSinai Medical Center - Los Angeles, California 2,601.4 miles None None None
    CedarsSinai Medical Center - Los Angeles, California 2,601.4 miles None None None
    CedarsSinai Medical Center - Los Angeles, California 2,601.4 miles None None None
    UC Davis Medical Center - Sacramento, California 2,628.4 miles None None None

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