A Safety Study of SGN-CD352A for Patients With Relapsed/Refractory Multiple Myeloma

Description

This study tests the safety of a drug called SGN-CD352A, to find out what its side effects are. SGN-CD352A will be given every 4 weeks to a small group of patients with multiple myeloma.

Study Start Date

December, 01 2016

Estimated Completion Date

December 2019

Interventions

  • Drug: SGN-CD352A

Study ID

Seattle Genetics, Inc. -- SGN352-001

Status

Unknown

Trial ID

NCT02954796

Study Type

Interventional

Trial Phase

Phase 1

Enrollment Quota

75

Sponsor

Seattle Genetics, Inc.

Inclusion Criteria

  • Diagnosis of MM requiring systemic therapy (per the International Myeloma Working Group [IMWG] ).
  • Age 18 years or older.
  • An Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1.
  • Life expectancy greater than months.
  • Received at least 2 prior lines of therapy for MM including an immunomodulatory drug and a proteasome inhibitor.
  • Measurable disease, as defined by at least one of the following: Serum M protein 0.5 g/dL or higher, Urine M protein 200 mg/24 hr or higher, Abnormal serum free light chain (SFLC) ratio.
  • Adequate hematologic, renal, and hepatic function
  • A negative pregnancy test (for females of childbearing potential).
  • Patients must provide written informed consent.

Exclusion Criteria

  • Other invasive malignancy within the past 3 years.
  • Active cerebral/meningeal disease related to the underlying malignancy.
  • Active Grade 3 or higher infection.
  • Known to be positive for HIV or known to have active hepatitis B or C.
  • Previous allogeneic stem cell transplant.
  • Idiopathic interstitial pneumonia or impaired diffusion capacity of the lung for carbon monoxide (DLCO).
  • Cerebrovascular or cardiovascular event, or congestive heart failure within the last 6 months.
  • Females who are pregnant or breastfeeding.

Gender

All

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (21)

Study Location Distance Name Phone Email
Hackensack University Medical Center - Hackensack, New Jersey 47.6 miles Laura McBride 551-996-8020 Laura.McBride@hackensackmeridian.org
Weill Cornell Medical College - New York, New York 50.7 miles Sophia Glickman 646-962-9338 sog2010@med.cornell.edu
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 512.3 miles Christiane Houde 313-576-9381 houdec@karmanos.org
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 512.3 miles Christiane Houde 313-576-9381 houdec@karmanos.org
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 512.3 miles Christiane Houde 313-576-9381 houdec@karmanos.org
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 512.3 miles Christiane Houde 313-576-9381 houdec@karmanos.org
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 795.6 miles Tolu Adewuya 404-778-1900 tolu.adewuya@emory.edu
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 795.6 miles Tolu Adewuya 404-778-1900 tolu.adewuya@emory.edu
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 795.6 miles Tolu Adewuya 404-778-1900 tolu.adewuya@emory.edu
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 795.6 miles Tolu Adewuya 404-778-1900 tolu.adewuya@emory.edu
Washington University School of Medicine - Saint Louis, Missouri 919.8 miles Phil Powell 314-747-2740 charles.powell@wustl.edu
Holden Comprehensive Cancer Center University of Iowa - Iowa City, Iowa 948.5 miles Meghan Chandler 319-467-5836 meghan-chandler@uiowa.edu
Holden Comprehensive Cancer Center University of Iowa - Iowa City, Iowa 948.5 miles Meghan Chandler 319-467-5836 meghan-chandler@uiowa.edu
Holden Comprehensive Cancer Center University of Iowa - Iowa City, Iowa 948.5 miles Meghan Chandler 319-467-5836 meghan-chandler@uiowa.edu
Holden Comprehensive Cancer Center University of Iowa - Iowa City, Iowa 948.5 miles Meghan Chandler 319-467-5836 meghan-chandler@uiowa.edu
Charles A Sammons Cancer Center Baylor University Medical Center - Dallas, Texas 1,420.1 miles Madel Fonlon 214-820-8471 Madel.fonlon@bswhealth.org
Charles A Sammons Cancer Center Baylor University Medical Center - Dallas, Texas 1,420.1 miles Madel Fonlon 214-820-8471 Madel.fonlon@bswhealth.org
Charles A Sammons Cancer Center Baylor University Medical Center - Dallas, Texas 1,420.1 miles Madel Fonlon 214-820-8471 Madel.fonlon@bswhealth.org
Charles A Sammons Cancer Center Baylor University Medical Center - Dallas, Texas 1,420.1 miles Madel Fonlon 214-820-8471 Madel.fonlon@bswhealth.org
Mayo Clinic Arizona - Scottsdale, Arizona 2,167.5 miles Mayo Clinic Clinical Trials Referral Office 855-776-0015 None
Swedish Cancer Institute - Seattle, Washington 2,426.6 miles Tenzin Tsomo 206-386-6000 tenzin.tsomo@swedish.org

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