A Safety Study of SGN-2FF for Patients With Advanced Solid Tumors

Description

This study will examine the safety profile of SGN-2FF. The study will test increasing doses of SGN-2FF given daily to small groups of patients.

Study Start Date

February, 23 2017

Estimated Completion Date

May 2022

Interventions

  • Drug: SGN-2FF

Study ID

Seattle Genetics, Inc. -- SGN2FF-001

Status

Recruiting

Trial ID

NCT02952989

Study Type

Interventional

Trial Phase

Phase 1

Enrollment Quota

158

Sponsor

Seattle Genetics, Inc.

Inclusion Criteria

  • Patients with histologically or cytologically-confirmed, locally advanced, or metastatic solid malignancy that is relapsed, refractory, or progressing following at least 1 prior systemic therapy
  • Measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI)
  • Eastern Cooperative Oncology Group (ECOG) performance status of less than or equal to 1
  • Patients in Part B must have histologically or cytologically-confirmed non-small cell lung cancer that is documented Stage IIIB or IV, or recurrent disease following radiation therapy or surgical resection
  • Adequate baseline hematologic, renal, and hepatic function

Exclusion Criteria

  • Patients with carcinomatous meningitis or active central nervous system (CNS) metastases
  • Patients with recent or serious ongoing infection
  • Patients requiring systemic treatment with corticosteroids (greater than 10 prednisone equivalents) or immunosuppressive medications within 14 days of enrollment
  • Patients with active known or suspected autoimmune disease or significant autoimmune-related toxicity from prior immuno-oncology therapy
  • Known active or latent tuberculosis
  • Uncontrolled diabetes mellitus
  • History of interstitial lung disease
  • Gastrointestinal abnormality that would affect absorption of SGN-2FF

Gender

All

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (21)

Study Location Distance Name Phone Email
Dana Farber Cancer Institute - Boston, Massachusetts 2.4 miles Elizabeth Downey 617-632-6840 ElizabethE_Downey@DFCI.HARVARD.EDU
Hackensack University Medical Center - Hackensack, New Jersey 183.7 miles Sora Limor 551-996-8598 SLimor@hackensackumc.org
Hackensack University Medical Center - Hackensack, New Jersey 183.7 miles Sora Limor 551-996-8598 SLimor@hackensackumc.org
Duke University Medical Center - Durham, North Carolina 609.0 miles John Strickler 919-684-8111 john.strickler@dm.duke.edu
Duke University Medical Center - Durham, North Carolina 609.0 miles John Strickler 919-684-8111 john.strickler@dm.duke.edu
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 611.5 miles Amy Weise 313-576-8624 weisea@karmanos.org
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 611.5 miles Amy Weise 313-576-8624 weisea@karmanos.org
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 611.5 miles Amy Weise 313-576-8624 weisea@karmanos.org
Karmanos Cancer Institute Wayne State University - Detroit, Michigan 611.5 miles Amy Weise 313-576-8624 weisea@karmanos.org
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 932.0 miles Conor Steuer MD 404-778-5378 Csteuer@emory.edu
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 932.0 miles Conor Steuer MD 404-778-5378 Csteuer@emory.edu
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 932.0 miles Conor Steuer MD 404-778-5378 Csteuer@emory.edu
Winship Cancer Institute Emory University School of Medicine - Atlanta, Georgia 932.0 miles Conor Steuer MD 404-778-5378 Csteuer@emory.edu
Sarah Cannon Research Institute - Nashville, Tennessee 932.4 miles Ask Sarah 877-691-7274 ASKSARAH@scresearch.net
Sarah Cannon Research Institute - Nashville, Tennessee 932.4 miles Ask Sarah 877-691-7274 ASKSARAH@scresearch.net
University of Alabama at Birmingham - Birmingham, Alabama 1,052.1 miles Francisco Robert MD 205-934-5077 pacorobertuab@cs.com
University of Alabama at Birmingham - Birmingham, Alabama 1,052.1 miles Francisco Robert MD 205-934-5077 pacorobertuab@cs.com
University of Alabama at Birmingham - Birmingham, Alabama 1,052.1 miles Francisco Robert MD 205-934-5077 pacorobertuab@cs.com
University of Alabama at Birmingham - Birmingham, Alabama 1,052.1 miles Francisco Robert MD 205-934-5077 pacorobertuab@cs.com
Providence Portland Medical Center - Portland, Oregon 2,533.3 miles Kim Sutcliffe 503-215-5763 kimberly.sutcliffe@providence.org
Providence Portland Medical Center - Portland, Oregon 2,533.3 miles Kim Sutcliffe 503-215-5763 kimberly.sutcliffe@providence.org

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