A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma

Description

This is a Phase IIb, randomized, placebo-controlled, double-blind, multicenter, multi-arm study will evaluate efficacy, safety, and pharmacokinetic of MSTT1041A compared with placebo as add-on therapy in participants with severe, uncontrolled asthma who are receiving medium- or high-dose inhaled corticosteroid (ICS) therapy and at least one of the following additional controller medications: long-acting beta-agonists (LABA), leukotriene modifier (LTM), long-acting muscarinic antagonist (LAMA), or long-acting theophylline preparation. The total duration of this study for each participant is approximately 70 weeks including screening, run-in, treatment, and follow-up.

Study Start Date

September, 20 2016

Estimated Completion Date

September 2019

Interventions

  • Drug: Placebo
  • Drug: MSTT1041A

Study ID

Hoffmann-La Roche -- GB39242

Status

Recruiting

Trial ID

NCT02918019

Study Type

Interventional

Trial Phase

Phase 2

Enrollment Quota

500

Sponsor

Hoffmann-La Roche

Inclusion Criteria

  • Body mass index (BMI) of 18 to 38 kilogram/square meter (kg/m^2) and weight >= 40 kg at screening
  • Documented physician-diagnosed asthma
  • On high dose inhaled corticosteroid (ICS) therapy plus at least one additional allowed controller medication
  • Forced expiratory volume in 1 second (FEV1) of 40% to 80% of predicted
  • Evidence of uncontrolled asthma
  • Use of contraceptive measures

Exclusion Criteria

  • Diagnosis of mimics of asthma
  • Diagnosis of occupational asthma, aspirin-sensitive asthma, asthma chronic obstructive pulmonary disease overlap syndrome, or bronchiolitis, as determined by the investigator
  • Pregnant or lactating, or intending to become pregnant during the study or within 20 weeks after the last dose of MSTT1041A
  • Recent history of smoking
  • History or evidence of substance abuse that would pose a risk to participants safety, interfere with the conduct of the study, have an impact on the study results
  • Asthma exacerbation within 4 weeks prior to screening
  • Intubation for respiratory failure due to asthma within 12 months prior to screening
  • Comorbid conditions that may interfere with evaluation of investigational medicinal product
  • Known sensitivity to any of the active substances or their excipients to be administered during dosing
  • Positive pregnancy test

Gender

All

Ages

18 Years to 75 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (254)

Study Location Distance Name Phone Email
Brigham WomenS Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham WomenS Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham WomenS Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham WomenS Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham WomenS Hospital - Boston, Massachusetts 2.6 miles None None None
Infinity Medical Research Inc - North Dartmouth, Massachusetts 40.0 miles None None None
Infinity Medical Research Inc - North Dartmouth, Massachusetts 40.0 miles None None None
Infinity Medical Research Inc - North Dartmouth, Massachusetts 40.0 miles None None None
Infinity Medical Research Inc - North Dartmouth, Massachusetts 40.0 miles None None None
Genesis Clinical Research Consulting LLC - Fall River, Massachusetts 44.9 miles None None None
Genesis Clinical Research Consulting LLC - Fall River, Massachusetts 44.9 miles None None None
Genesis Clinical Research Consulting LLC - Fall River, Massachusetts 44.9 miles None None None
Genesis Clinical Research Consulting LLC - Fall River, Massachusetts 44.9 miles None None None
Genesis Clinical Research Consulting LLC - Fall River, Massachusetts 44.9 miles None None None
Asthma Allergy Physicians of Rhode Island Clinical Research Institute AAPRI CRI - Warwick, Rhode Island 57.0 miles None None None
Asthma Allergy Physicians of Rhode Island Clinical Research Institute AAPRI CRI - Warwick, Rhode Island 57.0 miles None None None
Asthma Allergy Physicians of Rhode Island Clinical Research Institute AAPRI CRI - Warwick, Rhode Island 57.0 miles None None None
Asthma Allergy Physicians of Rhode Island Clinical Research Institute AAPRI CRI - Warwick, Rhode Island 57.0 miles None None None
Asthma Allergy Physicians of Rhode Island Clinical Research Institute AAPRI CRI - Warwick, Rhode Island 57.0 miles None None None
Yale University School Of Medicine - New Haven, Connecticut 119.2 miles None None None
Yale University School Of Medicine - New Haven, Connecticut 119.2 miles None None None
Yale University School Of Medicine - New Haven, Connecticut 119.2 miles None None None
Montefiore Medical Center - The Bronx, New York 176.6 miles None None None
Montefiore Medical Center - The Bronx, New York 176.6 miles None None None
Montefiore Medical Center - The Bronx, New York 176.6 miles None None None
Montefiore Medical Center - The Bronx, New York 176.6 miles None None None
Montefiore Medical Center - The Bronx, New York 176.6 miles None None None
Atlantic Allergy Asthma Immunology Associates - Ocean City, New Jersey 212.1 miles None None None
Atlantic Allergy Asthma Immunology Associates - Ocean City, New Jersey 212.1 miles None None None
Atlantic Allergy Asthma Immunology Associates - Ocean City, New Jersey 212.1 miles None None None
Atlantic Allergy Asthma Immunology Associates - Ocean City, New Jersey 212.1 miles None None None
Atlantic Allergy Asthma Immunology Associates - Ocean City, New Jersey 212.1 miles None None None
Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
Temple University Hospital - Philadelphia, Pennsylvania 266.2 miles None None None
Asthma Allergy Pulm Associates - Philadelphia, Pennsylvania 269.5 miles None None None
Asthma Allergy Pulm Associates - Philadelphia, Pennsylvania 269.5 miles None None None
Asthma Allergy Pulm Associates - Philadelphia, Pennsylvania 269.5 miles None None None
Asthma Allergy Pulm Associates - Philadelphia, Pennsylvania 269.5 miles None None None
Asthma Allergy Pulm Associates - Philadelphia, Pennsylvania 269.5 miles None None None
Chesapeake Clinical Research Inc CRN - Baltimore, Maryland 349.6 miles None None None
Chesapeake Clinical Research Inc CRN - Baltimore, Maryland 349.6 miles None None None
Asthma Allergy Sinus Center - Baltimore, Maryland 349.6 miles None None None
Chesapeake Clinical Research Inc CRN - Baltimore, Maryland 349.6 miles None None None
Chesapeake Clinical Research Inc CRN - Baltimore, Maryland 349.6 miles None None None
Chesapeake Clinical Research Inc CRN - Baltimore, Maryland 349.6 miles None None None
Asthma Allergy Sinus Center - Baltimore, Maryland 349.6 miles None None None
Asthma Allergy Sinus Center - Baltimore, Maryland 349.6 miles None None None
Asthma Allergy Sinus Center - Baltimore, Maryland 349.6 miles None None None
Asthma Allergy Sinus Center - Baltimore, Maryland 349.6 miles None None None
Commonwealth Clinical Research Specialists - Richmond, Virginia 475.0 miles None None None
Commonwealth Clinical Research Specialists - Richmond, Virginia 475.0 miles None None None
Commonwealth Clinical Research Specialists - Richmond, Virginia 475.0 miles None None None
Commonwealth Clinical Research Specialists - Richmond, Virginia 475.0 miles None None None
Commonwealth Clinical Research Specialists - Richmond, Virginia 475.0 miles None None None
Allergy Respiratory Center - Canton, Ohio 545.3 miles None None None
Allergy Respiratory Center - Canton, Ohio 545.3 miles None None None
Allergy Respiratory Center - Canton, Ohio 545.3 miles None None None
Allergy Respiratory Center - Canton, Ohio 545.3 miles None None None
Allergy Respiratory Center - Canton, Ohio 545.3 miles None None None
Allied Clinical Research LLC - Springfield, Ohio 684.1 miles None None None
Allied Clinical Research LLC - Springfield, Ohio 684.1 miles None None None
Allied Clinical Research LLC - Springfield, Ohio 684.1 miles None None None
Allied Clinical Research LLC - Springfield, Ohio 684.1 miles None None None
Allied Clinical Research LLC - Springfield, Ohio 684.1 miles None None None
Allergy Partners of Western NC - Asheville, North Carolina 773.5 miles None None None
Allergy Partners of Western NC - Asheville, North Carolina 773.5 miles None None None
Allergy Partners of Western NC - Asheville, North Carolina 773.5 miles None None None
Allergy Partners of Western NC - Asheville, North Carolina 773.5 miles None None None
Allergy Partners of Western NC - Asheville, North Carolina 773.5 miles None None None
Spartanburg Medical Research - Spartanburg, South Carolina 776.4 miles None None None
Spartanburg Medical Research - Spartanburg, South Carolina 776.4 miles None None None
Spartanburg Medical Research - Spartanburg, South Carolina 776.4 miles None None None
Spartanburg Medical Research - Spartanburg, South Carolina 776.4 miles None None None
Spartanburg Medical Research - Spartanburg, South Carolina 776.4 miles None None None
Clinical Research Solutions PC - Knoxville, Tennessee 817.2 miles None None None
Clinical Research Solutions PC - Knoxville, Tennessee 817.2 miles None None None
Clinical Research Solutions PC - Knoxville, Tennessee 817.2 miles None None None
Clinical Research Solutions PC - Knoxville, Tennessee 817.2 miles None None None
Clinical Research Solutions PC - Knoxville, Tennessee 817.2 miles None None None
Atlanta Allergy Asth Clin PC - Stockbridge, Georgia 938.9 miles None None None
Atlanta Allergy Asth Clin PC - Stockbridge, Georgia 938.9 miles None None None
Atlanta Allergy Asth Clin PC - Stockbridge, Georgia 938.9 miles None None None
Atlanta Allergy Asth Clin PC - Stockbridge, Georgia 938.9 miles None None None
Atlanta Allergy Asth Clin PC - Stockbridge, Georgia 938.9 miles None None None
Meharry Medical College Clinical Trials Office - Nashville, Tennessee 943.1 miles None None None
Meharry Medical College Clinical Trials Office - Nashville, Tennessee 943.1 miles None None None
Meharry Medical College Clinical Trials Office - Nashville, Tennessee 943.1 miles None None None
Meharry Medical College Clinical Trials Office - Nashville, Tennessee 943.1 miles None None None
Meharry Medical College Clinical Trials Office - Nashville, Tennessee 943.1 miles None None None
Georgia Pollens Clinical Research Centers - Albany, Georgia 1,039.4 miles None None None
Georgia Pollens Clinical Research Centers - Albany, Georgia 1,039.4 miles None None None
Georgia Pollens Clinical Research Centers - Albany, Georgia 1,039.4 miles None None None
Georgia Pollens Clinical Research Centers - Albany, Georgia 1,039.4 miles None None None
Georgia Pollens Clinical Research Centers - Albany, Georgia 1,039.4 miles None None None
The Clinical Research Center LLC CRN - Saint Louis, Missouri 1,048.4 miles None None None
The Clinical Research Center LLC CRN - Saint Louis, Missouri 1,048.4 miles None None None
The Clinical Research Center LLC CRN - Saint Louis, Missouri 1,048.4 miles None None None
Midwest Clinical Research LLC - Saint Louis, Missouri 1,048.4 miles None None None
Midwest Clinical Research LLC - Saint Louis, Missouri 1,048.4 miles None None None
Midwest Clinical Research LLC - Saint Louis, Missouri 1,048.4 miles None None None
Midwest Clinical Research LLC - Saint Louis, Missouri 1,048.4 miles None None None
The Clinical Research Center LLC CRN - Saint Louis, Missouri 1,048.4 miles None None None
The Clinical Research Center LLC CRN - Saint Louis, Missouri 1,048.4 miles None None None
Midwest Clinical Research LLC - Saint Louis, Missouri 1,048.4 miles None None None
Alabama Allergy Asthma - Birmingham, Alabama 1,054.2 miles None None None
Alabama Allergy Asthma - Birmingham, Alabama 1,054.2 miles None None None
Alabama Allergy Asthma - Birmingham, Alabama 1,054.2 miles None None None
Alabama Allergy Asthma - Birmingham, Alabama 1,054.2 miles None None None
Alabama Allergy Asthma - Birmingham, Alabama 1,054.2 miles None None None
Florida Premier Research Institute - Winter Park, Florida 1,113.3 miles None None None
Florida Premier Research Institute - Winter Park, Florida 1,113.3 miles None None None
Florida Premier Research Institute - Winter Park, Florida 1,113.3 miles None None None
Florida Premier Research Institute - Winter Park, Florida 1,113.3 miles None None None
Florida Premier Research Institute - Winter Park, Florida 1,113.3 miles None None None
Emerald Coast Research Associates - Panama City, Florida 1,167.3 miles None None None
Emerald Coast Research Associates - Panama City, Florida 1,167.3 miles None None None
Emerald Coast Research Associates - Panama City, Florida 1,167.3 miles None None None
Emerald Coast Research Associates - Panama City, Florida 1,167.3 miles None None None
Emerald Coast Research Associates - Panama City, Florida 1,167.3 miles None None None
Research Institute of South Florida Inc - Miami, Florida 1,268.9 miles None None None
Research Institute of South Florida Inc - Miami, Florida 1,268.9 miles None None None
Research Institute of South Florida Inc - Miami, Florida 1,268.9 miles None None None
Creighton University Medical Center - Omaha, Nebraska 1,281.1 miles None None None
Creighton University Medical Center - Omaha, Nebraska 1,281.1 miles None None None
Creighton University Medical Center - Omaha, Nebraska 1,281.1 miles None None None
Creighton University Medical Center - Omaha, Nebraska 1,281.1 miles None None None
Creighton University Medical Center - Omaha, Nebraska 1,281.1 miles None None None
The Allergy and Asthma Center - Bellevue, Nebraska 1,283.0 miles None None None
Vital Prospects Clin Res Pc - Tulsa, Oklahoma 1,396.7 miles None None None
Vital Prospects Clin Res Pc - Tulsa, Oklahoma 1,396.7 miles None None None
Vital Prospects Clin Res Pc - Tulsa, Oklahoma 1,396.7 miles None None None
Vital Prospects Clin Res Pc - Tulsa, Oklahoma 1,396.7 miles None None None
Vital Prospects Clin Res Pc - Tulsa, Oklahoma 1,396.7 miles None None None
Oklahoma Institute of Allergy and Asthma Clinical Research LLC - Oklahoma City, Oklahoma 1,488.6 miles None None None
Oklahoma Institute of Allergy and Asthma Clinical Research LLC - Oklahoma City, Oklahoma 1,488.6 miles None None None
Oklahoma Institute of Allergy and Asthma Clinical Research LLC - Oklahoma City, Oklahoma 1,488.6 miles None None None
Oklahoma Institute of Allergy and Asthma Clinical Research LLC - Oklahoma City, Oklahoma 1,488.6 miles None None None
Oklahoma Institute of Allergy and Asthma Clinical Research LLC - Oklahoma City, Oklahoma 1,488.6 miles None None None
Integrity People Services Research Company - Oklahoma City, Oklahoma 1,493.9 miles None None None
Integrity People Services Research Company - Oklahoma City, Oklahoma 1,493.9 miles None None None
Integrity People Services Research Company - Oklahoma City, Oklahoma 1,493.9 miles None None None
Integrity People Services Research Company - Oklahoma City, Oklahoma 1,493.9 miles None None None
Integrity People Services Research Company - Oklahoma City, Oklahoma 1,493.9 miles None None None
Elliot J Ginchansky MD PA - Dallas, Texas 1,546.2 miles None None None
Elliot J Ginchansky MD PA - Dallas, Texas 1,546.2 miles None None None
Elliot J Ginchansky MD PA - Dallas, Texas 1,546.2 miles None None None
Elliot J Ginchansky MD PA - Dallas, Texas 1,546.2 miles None None None
Elliot J Ginchansky MD PA - Dallas, Texas 1,546.2 miles None None None
Baylor College of Medicine - Houston, Texas 1,609.9 miles None None None
Baylor College of Medicine - Houston, Texas 1,609.9 miles None None None
Baylor College of Medicine - Houston, Texas 1,609.9 miles None None None
Baylor College of Medicine - Houston, Texas 1,609.9 miles None None None
Baylor College of Medicine - Houston, Texas 1,609.9 miles None None None
Pioneer Research Solutions - Houston, Texas 1,620.2 miles None None None
Pioneer Research Solutions - Houston, Texas 1,620.2 miles None None None
Pioneer Research Solutions - Houston, Texas 1,620.2 miles None None None
Pioneer Research Solutions - Houston, Texas 1,620.2 miles None None None
Pioneer Research Solutions - Houston, Texas 1,620.2 miles None None None
TTS Research - Boerne, Texas 1,762.8 miles None None None
TTS Research - Boerne, Texas 1,762.8 miles None None None
TTS Research - Boerne, Texas 1,762.8 miles None None None
TTS Research - Boerne, Texas 1,762.8 miles None None None
TTS Research - Boerne, Texas 1,762.8 miles None None None
Colorado Allergy Asthma Centers Pc - Denver, Colorado 1,763.8 miles None None None
Colorado Allergy Asthma Centers Pc - Denver, Colorado 1,763.8 miles None None None
Colorado Allergy Asthma Centers Pc - Denver, Colorado 1,763.8 miles None None None
Colorado Allergy Asthma Centers Pc - Denver, Colorado 1,763.8 miles None None None
Colorado Allergy Asthma Centers Pc - Denver, Colorado 1,763.8 miles None None None
IMMUNOe International Research Centers - Centennial, Colorado 1,764.5 miles None None None
IMMUNOe International Research Centers - Centennial, Colorado 1,764.5 miles None None None
IMMUNOe International Research Centers - Centennial, Colorado 1,764.5 miles None None None
Allergy Asthma Research Center - San Antonio, Texas 1,768.2 miles None None None
Allergy Asthma Research Center - San Antonio, Texas 1,768.2 miles None None None
Allergy Asthma Research Center - San Antonio, Texas 1,768.2 miles None None None
Allergy Asthma Research Center - San Antonio, Texas 1,768.2 miles None None None
Allergy Asthma Research Center - San Antonio, Texas 1,768.2 miles None None None
Western States Clinical Research Inc - Wheat Ridge, Colorado 1,772.7 miles None None None
Western States Clinical Research Inc - Wheat Ridge, Colorado 1,772.7 miles None None None
Western States Clinical Research Inc - Wheat Ridge, Colorado 1,772.7 miles None None None
Western States Clinical Research Inc - Wheat Ridge, Colorado 1,772.7 miles None None None
Western States Clinical Research Inc - Wheat Ridge, Colorado 1,772.7 miles None None None
Asthma Allergy Associates PC - Colorado Springs, Colorado 1,777.2 miles None None None
Asthma Allergy Associates PC - Colorado Springs, Colorado 1,777.2 miles None None None
Asthma Allergy Associates PC - Colorado Springs, Colorado 1,777.2 miles None None None
Asthma Allergy Associates PC - Colorado Springs, Colorado 1,777.2 miles None None None
Asthma Allergy Associates PC - Colorado Springs, Colorado 1,777.2 miles None None None
Western Sky Medical Research - El Paso, Texas 2,068.3 miles None None None
Western Sky Medical Research - El Paso, Texas 2,068.3 miles None None None
Western Sky Medical Research - El Paso, Texas 2,068.3 miles None None None
Western Sky Medical Research - El Paso, Texas 2,068.3 miles None None None
Western Sky Medical Research - El Paso, Texas 2,068.3 miles None None None
Allergy Associates of Utah - Murray, Utah 2,098.3 miles None None None
Allergy Associates of Utah - Murray, Utah 2,098.3 miles None None None
Allergy Associates of Utah - Murray, Utah 2,098.3 miles None None None
Allergy Associates of Utah - Murray, Utah 2,098.3 miles None None None
Allergy Associates of Utah - Murray, Utah 2,098.3 miles None None None
Asthma Allergy of Idaho - Twin Falls, Idaho 2,196.8 miles None None None
Asthma Allergy of Idaho - Twin Falls, Idaho 2,196.8 miles None None None
Asthma Allergy of Idaho - Twin Falls, Idaho 2,196.8 miles None None None
Asthma Allergy of Idaho - Twin Falls, Idaho 2,196.8 miles None None None
Asthma Allergy of Idaho - Twin Falls, Idaho 2,196.8 miles None None None
Premier Clinical Research - Spokane, Washington 2,261.3 miles None None None
Premier Clinical Research - Spokane, Washington 2,261.3 miles None None None
Premier Clinical Research - Spokane, Washington 2,261.3 miles None None None
Premier Clinical Research - Spokane, Washington 2,261.3 miles None None None
Premier Clinical Research - Spokane, Washington 2,261.3 miles None None None
Del Sol Research Management - Tucson, Arizona 2,336.4 miles None None None
Washington Univ School of Med - Seattle, Washington 2,487.7 miles None None None
Washington Univ School of Med - Seattle, Washington 2,487.7 miles None None None
Washington Univ School of Med - Seattle, Washington 2,487.7 miles None None None
Washington Univ School of Med - Seattle, Washington 2,487.7 miles None None None
Washington Univ School of Med - Seattle, Washington 2,487.7 miles None None None
Advances in Medicine - Rancho Mirage, California 2,511.4 miles None None None
Allianz Medical and Research Center - Fountain Valley, California 2,590.7 miles None None None
Kern Allergy Med Clinic Inc - Bakersfield, California 2,593.4 miles None None None
Kern Allergy Med Clinic Inc - Bakersfield, California 2,593.4 miles None None None
Kern Allergy Med Clinic Inc - Bakersfield, California 2,593.4 miles None None None
Kern Allergy Med Clinic Inc - Bakersfield, California 2,593.4 miles None None None
Kern Allergy Med Clinic Inc - Bakersfield, California 2,593.4 miles None None None
Allergy Asthma Care Center of Southern California - Long Beach, California 2,595.4 miles None None None
Allergy Asthma Care Center of Southern California - Long Beach, California 2,595.4 miles None None None
Allergy Asthma Care Center of Southern California - Long Beach, California 2,595.4 miles None None None
Allergy Asthma Care Center of Southern California - Long Beach, California 2,595.4 miles None None None
Allergy Asthma Care Center of Southern California - Long Beach, California 2,595.4 miles None None None
Office of Robert N Wolfe MD - Los Angeles, California 2,601.4 miles None None None
Clinical Research Inst of Southern Oregon Pc - Medford, Oregon 2,605.9 miles None None None
Clinical Research Inst of Southern Oregon Pc - Medford, Oregon 2,605.9 miles None None None
Clinical Research Inst of Southern Oregon Pc - Medford, Oregon 2,605.9 miles None None None
Clinical Research Inst of Southern Oregon Pc - Medford, Oregon 2,605.9 miles None None None
Clinical Research Inst of Southern Oregon Pc - Medford, Oregon 2,605.9 miles None None None
Jonathan Corren MD Inc - Los Angeles, California 2,606.1 miles None None None
Jonathan Corren MD Inc - Los Angeles, California 2,606.1 miles None None None
CA Allergy Asthma Med Grp Medical Group Inc - Los Angeles, California 2,606.1 miles None None None
CA Allergy Asthma Med Grp Medical Group Inc - Los Angeles, California 2,606.1 miles None None None
CA Allergy Asthma Med Grp Medical Group Inc - Los Angeles, California 2,606.1 miles None None None
CA Allergy Asthma Med Grp Medical Group Inc - Los Angeles, California 2,606.1 miles None None None
Jonathan Corren MD Inc - Los Angeles, California 2,606.1 miles None None None
CA Allergy Asthma Med Grp Medical Group Inc - Los Angeles, California 2,606.1 miles None None None
Jonathan Corren MD Inc - Los Angeles, California 2,606.1 miles None None None
Jonathan Corren MD Inc - Los Angeles, California 2,606.1 miles None None None
Bensch Research Associates - Stockton, California 2,636.3 miles None None None
Allergy and Asthma Clinical Research Inc - Walnut Creek, California 2,673.8 miles None None None
Allergy and Asthma Clinical Research Inc - Walnut Creek, California 2,673.8 miles None None None
Allergy and Asthma Clinical Research Inc - Walnut Creek, California 2,673.8 miles None None None
Allergy and Asthma Clinical Research Inc - Walnut Creek, California 2,673.8 miles None None None
Allergy and Asthma Clinical Research Inc - Walnut Creek, California 2,673.8 miles None None None
Allergy Asthma Consultants - Redwood City, California 2,694.5 miles None None None
Allergy Asthma Consultants - Redwood City, California 2,694.5 miles None None None
Allergy Asthma Consultants - Redwood City, California 2,694.5 miles None None None
Allergy Asthma Consultants - Redwood City, California 2,694.5 miles None None None
Allergy Asthma Consultants - Redwood City, California 2,694.5 miles None None None

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