A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001)

Description

This is a randomized, placebo-controlled, parallel-group, multi-center, double-blind, event driven study of vericiguat (MK-1242) in participants with HFrEF. The primary hypothesis is vericiguat (MK-1242) is superior to placebo in increasing the time to first occurrence of the composite of cardiovascular (CV) death or heart failure (HF) hospitalization in participants with HFrEF.

Study Start Date

September, 20 2016

Estimated Completion Date

January 2020

Interventions

  • Drug: Placebo for Vericiguat
  • Drug: Vericiguat

Study ID

Merck Sharp & Dohme Corp. -- 1242-001

Status

Recruiting

Trial ID

NCT02861534

Study Type

Interventional

Trial Phase

Phase 3

Enrollment Quota

4872

Sponsor

Merck Sharp & Dohme Corp.

Inclusion Criteria

  • History of chronic HF (New York Heart Association [NYHA] Class II-IV) on standard therapy before qualifying HF decompensation
  • Previous HF hospitalization within 6 months prior to randomization or intravenous (IV) diuretic treatment for HF (without hospitalization) within 3 months.
  • Brain natriuretic peptide (BNP) levels: sinus rhythm-? 300 pg/mL
  • atrial fibrillation-? 500 pg/mL and N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) levels: sinus rhythm
  • ? 1000 pg/mL
  • atrial fibrillation
  • ? 1600 pg/mL within 30 days prior to randomization
  • Left ventricular ejection fraction (LVEF) of <45% assessed within 12 months prior to randomization by any method
  • If female, is not of reproductive potential or agrees to avoid becoming pregnant while receiving study drug and for 14 days after the last dose of study drug by complying with one of the following: practice abstinence from heterosexual activity or use (or have her partner use) acceptable contraception during heterosexual activity.

Exclusion Criteria

  • Clinically unstable at the time of randomization as defined by either the administration of any IV treatment within 24 hours prior to randomization, and/or systolic blood pressure (SBP) <100 mmHg or symptomatic hypotension
  • Current or anticipated use of long-acting nitrates or nitric oxide (NO) donors including isosorbide dinitrate, isosorbide 5-mononitrate, pentaerythritol tetranitrate, nicorandil or transdermal nitroglycerin (NTG) patch, and molsidomine
  • Current or anticipated use of phosphodiesterase type 5 (PDE5) inhibitors such as vardenafil, tadalafil, and sildenafil
  • Current use or anticipated use of a soluble guanylate cyclase (sGC) stimulator such as riociguat
  • Known allergy or sensitivity to any sGC stimulator
  • Awaiting heart transplantation (United Network for Organ Sharing Class 1A / 1B or equivalent), receiving continuous IV infusion of an inotrope, or has/anticipates receiving an implanted ventricular assist device
  • Primary valvular heart disease requiring surgery or intervention, or is within 3 months after valvular surgery or intervention
  • Hypertrophic obstructive cardiomyopathy
  • Acute myocarditis, amyloidosis, sarcoidosis, Takotsubo cardiomyopathy
  • Post-heart transplant cardiomyopathy
  • Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia
  • Acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction [NSTEMI], or ST elevation myocardial infarction [(STEMI]) or coronary revascularization (coronary artery bypass grafting [CABG] or percutaneous coronary intervention [PCI]) within 60 days, or indication for coronary revascularization at time of randomization
  • Symptomatic carotid stenosis, transient ischemic attack (TIA) or stroke within 60 days
  • Complex congenital heart disease
  • Active endocarditis or constrictive pericarditis
  • Estimated glomerular filtration rate (eGFR) <15 mL/min/1.73 m2 or chronic dialysis
  • Severe hepatic insufficiency such as with hepatic encephalopathy
  • Malignancy or other non-cardiac condition limiting life expectancy to <3 years
  • Require continuous home oxygen for severe pulmonary disease
  • Current alcohol and/or drug abuse
  • Participated in another interventional clinical study and treatment with another investigational product ?30 days prior to randomization or plans to participate in any other trial/investigation during the duration of this study
  • Mental or legal incapacitation and is unable to provide informed consent
  • Immediate family member (e.g., spouse, parent/legal guardian, sibling or child) who is involved with this study
  • Interstitial Lung Disease
  • Breastfeeding or plans to breastfeed during the course of the study

Gender

All

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (475)

Study Location Distance Name Phone Email
Call for Information Investigational Site 2488 - Boston, Massachusetts 2.8 miles None None None
Call for Information Investigational Site 2488 - Boston, Massachusetts 2.8 miles None None None
Call for Information Investigational Site 2488 - Boston, Massachusetts 2.8 miles None None None
Call for Information Investigational Site 2488 - Boston, Massachusetts 2.8 miles None None None
Call for Information Investigational Site 2488 - Boston, Massachusetts 2.8 miles None None None
Call for Information Investigational Site 2519 - Boston, Massachusetts 3.2 miles None None None
Call for Information Investigational Site 2519 - Boston, Massachusetts 3.2 miles None None None
Call for Information Investigational Site 2519 - Boston, Massachusetts 3.2 miles None None None
Call for Information Investigational Site 2519 - Boston, Massachusetts 3.2 miles None None None
Call for Information Investigational Site 2519 - Boston, Massachusetts 3.2 miles None None None
Call for Information Investigational Site 2490 - Scarborough, Maine 92.4 miles None None None
Call for Information Investigational Site 2490 - Scarborough, Maine 92.4 miles None None None
Call for Information Investigational Site 2490 - Scarborough, Maine 92.4 miles None None None
Call for Information Investigational Site 2490 - Scarborough, Maine 92.4 miles None None None
Call for Information Investigational Site 2490 - Scarborough, Maine 92.4 miles None None None
Call for Information Investigational Site 2503 - Stony Brook, New York 145.7 miles None None None
Call for Information Investigational Site 2503 - Stony Brook, New York 145.7 miles None None None
Call for Information Investigational Site 2503 - Stony Brook, New York 145.7 miles None None None
Call for Information Investigational Site 2503 - Stony Brook, New York 145.7 miles None None None
Call for Information Investigational Site 2503 - Stony Brook, New York 145.7 miles None None None
Call for Information Investigational Site 2538 - The Bronx, New York 176.6 miles None None None
Call for Information Investigational Site 2538 - The Bronx, New York 176.6 miles None None None
Call for Information Investigational Site 2538 - The Bronx, New York 176.6 miles None None None
Call for Information Investigational Site 2538 - The Bronx, New York 176.6 miles None None None
Call for Information Investigational Site 2538 - The Bronx, New York 176.6 miles None None None
Call for Information Investigational Site 2477 - New York, New York 181.2 miles None None None
Call for Information Investigational Site 2477 - New York, New York 181.2 miles None None None
Call for Information Investigational Site 2477 - New York, New York 181.2 miles None None None
Call for Information Investigational Site 2477 - New York, New York 181.2 miles None None None
Call for Information Investigational Site 2477 - New York, New York 181.2 miles None None None
Call for Information Investigational Site 2554 - Somerset, New Jersey 219.5 miles None None None
Call for Information Investigational Site 2554 - Somerset, New Jersey 219.5 miles None None None
Call for Information Investigational Site 2554 - Somerset, New Jersey 219.5 miles None None None
Call for Information Investigational Site 2554 - Somerset, New Jersey 219.5 miles None None None
Call for Information Investigational Site 2554 - Somerset, New Jersey 219.5 miles None None None
Call for Information Investigational Site 2459 - Doylestown, Pennsylvania 251.7 miles None None None
Call for Information Investigational Site 2459 - Doylestown, Pennsylvania 251.7 miles None None None
Call for Information Investigational Site 2459 - Doylestown, Pennsylvania 251.7 miles None None None
Call for Information Investigational Site 2459 - Doylestown, Pennsylvania 251.7 miles None None None
Call for Information Investigational Site 2459 - Doylestown, Pennsylvania 251.7 miles None None None
Call for Information Investigational Site 2450 - Voorhees, New Jersey 266.6 miles None None None
Call for Information Investigational Site 2450 - Voorhees, New Jersey 266.6 miles None None None
Call for Information Investigational Site 2450 - Voorhees, New Jersey 266.6 miles None None None
Call for Information Investigational Site 2450 - Voorhees, New Jersey 266.6 miles None None None
Call for Information Investigational Site 2450 - Voorhees, New Jersey 266.6 miles None None None
Call for Information Investigational Site 2489 - Haddon Heights, New Jersey 269.0 miles None None None
Call for Information Investigational Site 2489 - Haddon Heights, New Jersey 269.0 miles None None None
Call for Information Investigational Site 2489 - Haddon Heights, New Jersey 269.0 miles None None None
Call for Information Investigational Site 2489 - Haddon Heights, New Jersey 269.0 miles None None None
Call for Information Investigational Site 2489 - Haddon Heights, New Jersey 269.0 miles None None None
Call for Information Investigational Site 2440 - Philadelphia, Pennsylvania 269.5 miles None None None
Call for Information Investigational Site 2440 - Philadelphia, Pennsylvania 269.5 miles None None None
Call for Information Investigational Site 2440 - Philadelphia, Pennsylvania 269.5 miles None None None
Call for Information Investigational Site 2440 - Philadelphia, Pennsylvania 269.5 miles None None None
Call for Information Investigational Site 2440 - Philadelphia, Pennsylvania 269.5 miles None None None
Call for Information Investigational Site 2469 - Sewell, New Jersey 276.2 miles None None None
Call for Information Investigational Site 2469 - Sewell, New Jersey 276.2 miles None None None
Call for Information Investigational Site 2469 - Sewell, New Jersey 276.2 miles None None None
Call for Information Investigational Site 2469 - Sewell, New Jersey 276.2 miles None None None
Call for Information Investigational Site 2469 - Sewell, New Jersey 276.2 miles None None None
Call for Information Investigational Site 2421 - Elmer, New Jersey 288.1 miles None None None
Call for Information Investigational Site 2421 - Elmer, New Jersey 288.1 miles None None None
Call for Information Investigational Site 2421 - Elmer, New Jersey 288.1 miles None None None
Call for Information Investigational Site 2421 - Elmer, New Jersey 288.1 miles None None None
Call for Information Investigational Site 2421 - Elmer, New Jersey 288.1 miles None None None
Call for Information Investigational Site 2473 - Wilmington, Delaware 291.9 miles None None None
Call for Information Investigational Site 2473 - Wilmington, Delaware 291.9 miles None None None
Call for Information Investigational Site 2473 - Wilmington, Delaware 291.9 miles None None None
Call for Information Investigational Site 2473 - Wilmington, Delaware 291.9 miles None None None
Call for Information Investigational Site 2473 - Wilmington, Delaware 291.9 miles None None None
Call for Information Investigational Site 2573 - Hershey, Pennsylvania 321.7 miles None None None
Call for Information Investigational Site 2573 - Hershey, Pennsylvania 321.7 miles None None None
Call for Information Investigational Site 2573 - Hershey, Pennsylvania 321.7 miles None None None
Call for Information Investigational Site 2573 - Hershey, Pennsylvania 321.7 miles None None None
Call for Information Investigational Site 2573 - Hershey, Pennsylvania 321.7 miles None None None
Call for Information Investigational Site 2581 - Cheektowaga, New York 391.0 miles None None None
Call for Information Investigational Site 2581 - Cheektowaga, New York 391.0 miles None None None
Call for Information Investigational Site 2581 - Cheektowaga, New York 391.0 miles None None None
Call for Information Investigational Site 2581 - Cheektowaga, New York 391.0 miles None None None
Call for Information Investigational Site 2581 - Cheektowaga, New York 391.0 miles None None None
Call for Information Investigational Site 2543 - Washington, District of Columbia 391.7 miles None None None
Call for Information Investigational Site 2543 - Washington, District of Columbia 391.7 miles None None None
Call for Information Investigational Site 2543 - Washington, District of Columbia 391.7 miles None None None
Call for Information Investigational Site 2543 - Washington, District of Columbia 391.7 miles None None None
Call for Information Investigational Site 2543 - Washington, District of Columbia 391.7 miles None None None
Call for Information Investigational Site 2586 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2461 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2586 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2461 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2461 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2586 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2461 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2586 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2586 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2461 - Falls Church, Virginia 401.4 miles None None None
Call for Information Investigational Site 2587 - Manassass, Virginia 419.1 miles None None None
Call for Information Investigational Site 2587 - Manassass, Virginia 419.1 miles None None None
Call for Information Investigational Site 2587 - Manassass, Virginia 419.1 miles None None None
Call for Information Investigational Site 2587 - Manassass, Virginia 419.1 miles None None None
Call for Information Investigational Site 2587 - Manassass, Virginia 419.1 miles None None None
Call for Information Investigational Site 2571 - Norfolk, Virginia 471.1 miles None None None
Call for Information Investigational Site 2571 - Norfolk, Virginia 471.1 miles None None None
Call for Information Investigational Site 2571 - Norfolk, Virginia 471.1 miles None None None
Call for Information Investigational Site 2571 - Norfolk, Virginia 471.1 miles None None None
Call for Information Investigational Site 2571 - Norfolk, Virginia 471.1 miles None None None
Call for Information Investigational Site 2549 - Richmond, Virginia 477.2 miles None None None
Call for Information Investigational Site 2549 - Richmond, Virginia 477.2 miles None None None
Call for Information Investigational Site 2549 - Richmond, Virginia 477.2 miles None None None
Call for Information Investigational Site 2549 - Richmond, Virginia 477.2 miles None None None
Call for Information Investigational Site 2549 - Richmond, Virginia 477.2 miles None None None
Call for Information Investigational Site 2570 - Pittsburgh, Pennsylvania 478.5 miles None None None
Call for Information Investigational Site 2570 - Pittsburgh, Pennsylvania 478.5 miles None None None
Call for Information Investigational Site 2570 - Pittsburgh, Pennsylvania 478.5 miles None None None
Call for Information Investigational Site 2570 - Pittsburgh, Pennsylvania 478.5 miles None None None
Call for Information Investigational Site 2570 - Pittsburgh, Pennsylvania 478.5 miles None None None
Call for Information Investigational Site 2452 - Canton, Ohio 545.2 miles None None None
Call for Information Investigational Site 2452 - Canton, Ohio 545.2 miles None None None
Call for Information Investigational Site 2452 - Canton, Ohio 545.2 miles None None None
Call for Information Investigational Site 2452 - Canton, Ohio 545.2 miles None None None
Call for Information Investigational Site 2452 - Canton, Ohio 545.2 miles None None None
Call for Information Investigational Site 2501 - Chapel Hill, North Carolina 616.4 miles None None None
Call for Information Investigational Site 2501 - Chapel Hill, North Carolina 616.4 miles None None None
Call for Information Investigational Site 2501 - Chapel Hill, North Carolina 616.4 miles None None None
Call for Information Investigational Site 2501 - Chapel Hill, North Carolina 616.4 miles None None None
Call for Information Investigational Site 2501 - Chapel Hill, North Carolina 616.4 miles None None None
Call for Information Investigational Site 2592 - Southfield, Michigan 619.5 miles None None None
Call for Information Investigational Site 2592 - Southfield, Michigan 619.5 miles None None None
Call for Information Investigational Site 2592 - Southfield, Michigan 619.5 miles None None None
Call for Information Investigational Site 2592 - Southfield, Michigan 619.5 miles None None None
Call for Information Investigational Site 2592 - Southfield, Michigan 619.5 miles None None None
Call for Information Investigational Site 2485 - Greensboro, North Carolina 637.0 miles None None None
Call for Information Investigational Site 2485 - Greensboro, North Carolina 637.0 miles None None None
Call for Information Investigational Site 2485 - Greensboro, North Carolina 637.0 miles None None None
Call for Information Investigational Site 2485 - Greensboro, North Carolina 637.0 miles None None None
Call for Information Investigational Site 2485 - Greensboro, North Carolina 637.0 miles None None None
Call for Information Investigational Site 2556 - Grand Blanc, Michigan 639.2 miles None None None
Call for Information Investigational Site 2556 - Grand Blanc, Michigan 639.2 miles None None None
Call for Information Investigational Site 2556 - Grand Blanc, Michigan 639.2 miles None None None
Call for Information Investigational Site 2556 - Grand Blanc, Michigan 639.2 miles None None None
Call for Information Investigational Site 2556 - Grand Blanc, Michigan 639.2 miles None None None
Call for Information Investigational Site 2595 - Lansing, Michigan 684.6 miles None None None
Call for Information Investigational Site 2595 - Lansing, Michigan 684.6 miles None None None
Call for Information Investigational Site 2595 - Lansing, Michigan 684.6 miles None None None
Call for Information Investigational Site 2595 - Lansing, Michigan 684.6 miles None None None
Call for Information Investigational Site 2595 - Lansing, Michigan 684.6 miles None None None
Call for Information Investigational Site 2500 - Charlotte, North Carolina 720.9 miles None None None
Call for Information Investigational Site 2500 - Charlotte, North Carolina 720.9 miles None None None
Call for Information Investigational Site 2500 - Charlotte, North Carolina 720.9 miles None None None
Call for Information Investigational Site 2500 - Charlotte, North Carolina 720.9 miles None None None
Call for Information Investigational Site 2500 - Charlotte, North Carolina 720.9 miles None None None
Call for Information Investigational Site 2443 - Richmond, Indiana 739.9 miles None None None
Call for Information Investigational Site 2443 - Richmond, Indiana 739.9 miles None None None
Call for Information Investigational Site 2443 - Richmond, Indiana 739.9 miles None None None
Call for Information Investigational Site 2443 - Richmond, Indiana 739.9 miles None None None
Call for Information Investigational Site 2443 - Richmond, Indiana 739.9 miles None None None
Call for Information Investigational Site 2593 - Kalamazoo, Michigan 740.8 miles None None None
Call for Information Investigational Site 2593 - Kalamazoo, Michigan 740.8 miles None None None
Call for Information Investigational Site 2593 - Kalamazoo, Michigan 740.8 miles None None None
Call for Information Investigational Site 2593 - Kalamazoo, Michigan 740.8 miles None None None
Call for Information Investigational Site 2593 - Kalamazoo, Michigan 740.8 miles None None None
Call for Information Investigational Site 2424 - Muncie, Indiana 756.7 miles None None None
Call for Information Investigational Site 2424 - Muncie, Indiana 756.7 miles None None None
Call for Information Investigational Site 2424 - Muncie, Indiana 756.7 miles None None None
Call for Information Investigational Site 2424 - Muncie, Indiana 756.7 miles None None None
Call for Information Investigational Site 2424 - Muncie, Indiana 756.7 miles None None None
Call for Information Investigational Site 2431 - Anderson, Indiana 778.0 miles None None None
Call for Information Investigational Site 2431 - Anderson, Indiana 778.0 miles None None None
Call for Information Investigational Site 2431 - Anderson, Indiana 778.0 miles None None None
Call for Information Investigational Site 2431 - Anderson, Indiana 778.0 miles None None None
Call for Information Investigational Site 2431 - Anderson, Indiana 778.0 miles None None None
Call for Information Investigational Site 2474 - Greenville, South Carolina 800.4 miles None None None
Call for Information Investigational Site 2474 - Greenville, South Carolina 800.4 miles None None None
Call for Information Investigational Site 2474 - Greenville, South Carolina 800.4 miles None None None
Call for Information Investigational Site 2474 - Greenville, South Carolina 800.4 miles None None None
Call for Information Investigational Site 2474 - Greenville, South Carolina 800.4 miles None None None
Call for Information Investigational Site 2455 - Indianapolis, Indiana 804.1 miles None None None
Call for Information Investigational Site 2455 - Indianapolis, Indiana 804.1 miles None None None
Call for Information Investigational Site 2455 - Indianapolis, Indiana 804.1 miles None None None
Call for Information Investigational Site 2455 - Indianapolis, Indiana 804.1 miles None None None
Call for Information Investigational Site 2455 - Indianapolis, Indiana 804.1 miles None None None
Call for Information Investigational Site 2436 - Louisville, Kentucky 820.8 miles None None None
Call for Information Investigational Site 2436 - Louisville, Kentucky 820.8 miles None None None
Call for Information Investigational Site 2436 - Louisville, Kentucky 820.8 miles None None None
Call for Information Investigational Site 2436 - Louisville, Kentucky 820.8 miles None None None
Call for Information Investigational Site 2436 - Louisville, Kentucky 820.8 miles None None None
Call for Information Investigational Site 2456 - Charleston, South Carolina 822.5 miles None None None
Call for Information Investigational Site 2456 - Charleston, South Carolina 822.5 miles None None None
Call for Information Investigational Site 2456 - Charleston, South Carolina 822.5 miles None None None
Call for Information Investigational Site 2456 - Charleston, South Carolina 822.5 miles None None None
Call for Information Investigational Site 2456 - Charleston, South Carolina 822.5 miles None None None
Call for Information Investigational Site 2752 - Munster, Indiana 845.3 miles None None None
Call for Information Investigational Site 2752 - Munster, Indiana 845.3 miles None None None
Call for Information Investigational Site 2752 - Munster, Indiana 845.3 miles None None None
Call for Information Investigational Site 2752 - Munster, Indiana 845.3 miles None None None
Call for Information Investigational Site 2752 - Munster, Indiana 845.3 miles None None None
Call for Information Investigational Site 2492 - Milwaukee, Wisconsin 857.3 miles None None None
Call for Information Investigational Site 2492 - Milwaukee, Wisconsin 857.3 miles None None None
Call for Information Investigational Site 2492 - Milwaukee, Wisconsin 857.3 miles None None None
Call for Information Investigational Site 2492 - Milwaukee, Wisconsin 857.3 miles None None None
Call for Information Investigational Site 2492 - Milwaukee, Wisconsin 857.3 miles None None None
Call for Information Investigational Site 2429 - Gainesville, Georgia 887.4 miles None None None
Call for Information Investigational Site 2429 - Gainesville, Georgia 887.4 miles None None None
Call for Information Investigational Site 2429 - Gainesville, Georgia 887.4 miles None None None
Call for Information Investigational Site 2429 - Gainesville, Georgia 887.4 miles None None None
Call for Information Investigational Site 2429 - Gainesville, Georgia 887.4 miles None None None
Call for Information Investigational Site 2453 - Madison, Wisconsin 932.2 miles None None None
Call for Information Investigational Site 2453 - Madison, Wisconsin 932.2 miles None None None
Call for Information Investigational Site 2453 - Madison, Wisconsin 932.2 miles None None None
Call for Information Investigational Site 2453 - Madison, Wisconsin 932.2 miles None None None
Call for Information Investigational Site 2453 - Madison, Wisconsin 932.2 miles None None None
Call for Information Investigational Site 2557 - Atlanta, Georgia 934.9 miles None None None
Call for Information Investigational Site 2557 - Atlanta, Georgia 934.9 miles None None None
Call for Information Investigational Site 2557 - Atlanta, Georgia 934.9 miles None None None
Call for Information Investigational Site 2557 - Atlanta, Georgia 934.9 miles None None None
Call for Information Investigational Site 2557 - Atlanta, Georgia 934.9 miles None None None
Call for Information Investigational Site 2442 - Nashville, Tennessee 942.8 miles None None None
Call for Information Investigational Site 2442 - Nashville, Tennessee 942.8 miles None None None
Call for Information Investigational Site 2442 - Nashville, Tennessee 942.8 miles None None None
Call for Information Investigational Site 2442 - Nashville, Tennessee 942.8 miles None None None
Call for Information Investigational Site 2442 - Nashville, Tennessee 942.8 miles None None None
Call for Information Investigational Site 2483 - Nashville, Tennessee 944.3 miles None None None
Call for Information Investigational Site 2483 - Nashville, Tennessee 944.3 miles None None None
Call for Information Investigational Site 2483 - Nashville, Tennessee 944.3 miles None None None
Call for Information Investigational Site 2483 - Nashville, Tennessee 944.3 miles None None None
Call for Information Investigational Site 2483 - Nashville, Tennessee 944.3 miles None None None
Call for Information Investigational Site 2482 - Wausau, Wisconsin 944.6 miles None None None
Call for Information Investigational Site 2482 - Wausau, Wisconsin 944.6 miles None None None
Call for Information Investigational Site 2482 - Wausau, Wisconsin 944.6 miles None None None
Call for Information Investigational Site 2482 - Wausau, Wisconsin 944.6 miles None None None
Call for Information Investigational Site 2482 - Wausau, Wisconsin 944.6 miles None None None
Call for Information Investigational Site 2575 - Tullahoma, Tennessee 945.9 miles None None None
Call for Information Investigational Site 2575 - Tullahoma, Tennessee 945.9 miles None None None
Call for Information Investigational Site 2575 - Tullahoma, Tennessee 945.9 miles None None None
Call for Information Investigational Site 2575 - Tullahoma, Tennessee 945.9 miles None None None
Call for Information Investigational Site 2575 - Tullahoma, Tennessee 945.9 miles None None None
Call for Information Investigational Site 2730 - Fayetteville, Georgia 954.7 miles None None None
Call for Information Investigational Site 2730 - Fayetteville, Georgia 954.7 miles None None None
Call for Information Investigational Site 2730 - Fayetteville, Georgia 954.7 miles None None None
Call for Information Investigational Site 2730 - Fayetteville, Georgia 954.7 miles None None None
Call for Information Investigational Site 2730 - Fayetteville, Georgia 954.7 miles None None None
Call for Information Investigational Site 2414 - Peoria, Illinois 962.1 miles None None None
Call for Information Investigational Site 2414 - Peoria, Illinois 962.1 miles None None None
Call for Information Investigational Site 2414 - Peoria, Illinois 962.1 miles None None None
Call for Information Investigational Site 2414 - Peoria, Illinois 962.1 miles None None None
Call for Information Investigational Site 2414 - Peoria, Illinois 962.1 miles None None None
Call for Information Investigational Site 2565 - Peoria, Illinois 964.5 miles None None None
Call for Information Investigational Site 2565 - Peoria, Illinois 964.5 miles None None None
Call for Information Investigational Site 2565 - Peoria, Illinois 964.5 miles None None None
Call for Information Investigational Site 2565 - Peoria, Illinois 964.5 miles None None None
Call for Information Investigational Site 2565 - Peoria, Illinois 964.5 miles None None None
Call for Information Investigational Site 2550 - Jacksonville, Florida 1,018.5 miles None None None
Call for Information Investigational Site 2550 - Jacksonville, Florida 1,018.5 miles None None None
Call for Information Investigational Site 2550 - Jacksonville, Florida 1,018.5 miles None None None
Call for Information Investigational Site 2550 - Jacksonville, Florida 1,018.5 miles None None None
Call for Information Investigational Site 2550 - Jacksonville, Florida 1,018.5 miles None None None
Call for Information Investigational Site 2460 - Jacksonville, Florida 1,019.5 miles None None None
Call for Information Investigational Site 2460 - Jacksonville, Florida 1,019.5 miles None None None
Call for Information Investigational Site 2460 - Jacksonville, Florida 1,019.5 miles None None None
Call for Information Investigational Site 2460 - Jacksonville, Florida 1,019.5 miles None None None
Call for Information Investigational Site 2460 - Jacksonville, Florida 1,019.5 miles None None None
Call for Information Investigational Site 2510 - Columbus, Georgia 1,021.2 miles None None None
Call for Information Investigational Site 2510 - Columbus, Georgia 1,021.2 miles None None None
Call for Information Investigational Site 2510 - Columbus, Georgia 1,021.2 miles None None None
Call for Information Investigational Site 2510 - Columbus, Georgia 1,021.2 miles None None None
Call for Information Investigational Site 2510 - Columbus, Georgia 1,021.2 miles None None None
Call for Information Investigational Site 2552 - Saint Louis, Missouri 1,036.5 miles None None None
Call for Information Investigational Site 2552 - Saint Louis, Missouri 1,036.5 miles None None None
Call for Information Investigational Site 2552 - Saint Louis, Missouri 1,036.5 miles None None None
Call for Information Investigational Site 2552 - Saint Louis, Missouri 1,036.5 miles None None None
Call for Information Investigational Site 2552 - Saint Louis, Missouri 1,036.5 miles None None None
Call for Information Investigational Site 2422 - Saint Augustine, Florida 1,041.7 miles None None None
Call for Information Investigational Site 2422 - Saint Augustine, Florida 1,041.7 miles None None None
Call for Information Investigational Site 2422 - Saint Augustine, Florida 1,041.7 miles None None None
Call for Information Investigational Site 2422 - Saint Augustine, Florida 1,041.7 miles None None None
Call for Information Investigational Site 2422 - Saint Augustine, Florida 1,041.7 miles None None None
Call for Information Investigational Site 2437 - Iowa City, Iowa 1,050.4 miles None None None
Call for Information Investigational Site 2437 - Iowa City, Iowa 1,050.4 miles None None None
Call for Information Investigational Site 2437 - Iowa City, Iowa 1,050.4 miles None None None
Call for Information Investigational Site 2437 - Iowa City, Iowa 1,050.4 miles None None None
Call for Information Investigational Site 2437 - Iowa City, Iowa 1,050.4 miles None None None
Call for Information Investigational Site 2727 - Thomasville, Georgia 1,069.8 miles None None None
Call for Information Investigational Site 2727 - Thomasville, Georgia 1,069.8 miles None None None
Call for Information Investigational Site 2727 - Thomasville, Georgia 1,069.8 miles None None None
Call for Information Investigational Site 2727 - Thomasville, Georgia 1,069.8 miles None None None
Call for Information Investigational Site 2727 - Thomasville, Georgia 1,069.8 miles None None None
Call for Information Investigational Site 2449 - Gainesville, Florida 1,081.3 miles None None None
Call for Information Investigational Site 2449 - Gainesville, Florida 1,081.3 miles None None None
Call for Information Investigational Site 2449 - Gainesville, Florida 1,081.3 miles None None None
Call for Information Investigational Site 2449 - Gainesville, Florida 1,081.3 miles None None None
Call for Information Investigational Site 2449 - Gainesville, Florida 1,081.3 miles None None None
Call for Information Investigational Site 2404 - Saint Paul, Minnesota 1,114.3 miles None None None
Call for Information Investigational Site 2404 - Saint Paul, Minnesota 1,114.3 miles None None None
Call for Information Investigational Site 2404 - Saint Paul, Minnesota 1,114.3 miles None None None
Call for Information Investigational Site 2404 - Saint Paul, Minnesota 1,114.3 miles None None None
Call for Information Investigational Site 2404 - Saint Paul, Minnesota 1,114.3 miles None None None
Call for Information Investigational Site 2478 - Saint Paul, Minnesota 1,125.1 miles None None None
Call for Information Investigational Site 2478 - Saint Paul, Minnesota 1,125.1 miles None None None
Call for Information Investigational Site 2478 - Saint Paul, Minnesota 1,125.1 miles None None None
Call for Information Investigational Site 2478 - Saint Paul, Minnesota 1,125.1 miles None None None
Call for Information Investigational Site 2478 - Saint Paul, Minnesota 1,125.1 miles None None None
Call for Information Investigational Site 2448 - Saint Cloud, Minnesota 1,168.8 miles None None None
Call for Information Investigational Site 2448 - Saint Cloud, Minnesota 1,168.8 miles None None None
Call for Information Investigational Site 2448 - Saint Cloud, Minnesota 1,168.8 miles None None None
Call for Information Investigational Site 2448 - Saint Cloud, Minnesota 1,168.8 miles None None None
Call for Information Investigational Site 2448 - Saint Cloud, Minnesota 1,168.8 miles None None None
Call for Information Investigational Site 2533 - Safety Harbor, Florida 1,189.2 miles None None None
Call for Information Investigational Site 2533 - Safety Harbor, Florida 1,189.2 miles None None None
Call for Information Investigational Site 2533 - Safety Harbor, Florida 1,189.2 miles None None None
Call for Information Investigational Site 2533 - Safety Harbor, Florida 1,189.2 miles None None None
Call for Information Investigational Site 2533 - Safety Harbor, Florida 1,189.2 miles None None None
Call for Information Investigational Site 2528 - Largo, Florida 1,200.1 miles None None None
Call for Information Investigational Site 2528 - Largo, Florida 1,200.1 miles None None None
Call for Information Investigational Site 2528 - Largo, Florida 1,200.1 miles None None None
Call for Information Investigational Site 2528 - Largo, Florida 1,200.1 miles None None None
Call for Information Investigational Site 2528 - Largo, Florida 1,200.1 miles None None None
Call for Information Investigational Site 2402 - Clearwater, Florida 1,202.2 miles None None None
Call for Information Investigational Site 2402 - Clearwater, Florida 1,202.2 miles None None None
Call for Information Investigational Site 2402 - Clearwater, Florida 1,202.2 miles None None None
Call for Information Investigational Site 2402 - Clearwater, Florida 1,202.2 miles None None None
Call for Information Investigational Site 2402 - Clearwater, Florida 1,202.2 miles None None None
Call for Information Investigational Site 2435 - Fort Lauderdale, Florida 1,231.7 miles None None None
Call for Information Investigational Site 2435 - Fort Lauderdale, Florida 1,231.7 miles None None None
Call for Information Investigational Site 2435 - Fort Lauderdale, Florida 1,231.7 miles None None None
Call for Information Investigational Site 2435 - Fort Lauderdale, Florida 1,231.7 miles None None None
Call for Information Investigational Site 2435 - Fort Lauderdale, Florida 1,231.7 miles None None None
Call for Information Investigational Site 2589 - Hollywood, Florida 1,244.0 miles None None None
Call for Information Investigational Site 2589 - Hollywood, Florida 1,244.0 miles None None None
Call for Information Investigational Site 2589 - Hollywood, Florida 1,244.0 miles None None None
Call for Information Investigational Site 2589 - Hollywood, Florida 1,244.0 miles None None None
Call for Information Investigational Site 2589 - Hollywood, Florida 1,244.0 miles None None None
Call for Information Investigational Site 2405 - Mobile, Alabama 1,244.2 miles None None None
Call for Information Investigational Site 2405 - Mobile, Alabama 1,244.2 miles None None None
Call for Information Investigational Site 2405 - Mobile, Alabama 1,244.2 miles None None None
Call for Information Investigational Site 2405 - Mobile, Alabama 1,244.2 miles None None None
Call for Information Investigational Site 2405 - Mobile, Alabama 1,244.2 miles None None None
Call for Information Investigational Site 2467 - Pembroke Pines, Florida 1,246.6 miles None None None
Call for Information Investigational Site 2467 - Pembroke Pines, Florida 1,246.6 miles None None None
Call for Information Investigational Site 2467 - Pembroke Pines, Florida 1,246.6 miles None None None
Call for Information Investigational Site 2467 - Pembroke Pines, Florida 1,246.6 miles None None None
Call for Information Investigational Site 2467 - Pembroke Pines, Florida 1,246.6 miles None None None
Call for Information Investigational Site 2484 - Kansas City, Missouri 1,250.3 miles None None None
Call for Information Investigational Site 2484 - Kansas City, Missouri 1,250.3 miles None None None
Call for Information Investigational Site 2484 - Kansas City, Missouri 1,250.3 miles None None None
Call for Information Investigational Site 2484 - Kansas City, Missouri 1,250.3 miles None None None
Call for Information Investigational Site 2484 - Kansas City, Missouri 1,250.3 miles None None None
Call for Information Investigational Site 2438 - Jackson, Mississippi 1,254.0 miles None None None
Call for Information Investigational Site 2438 - Jackson, Mississippi 1,254.0 miles None None None
Call for Information Investigational Site 2438 - Jackson, Mississippi 1,254.0 miles None None None
Call for Information Investigational Site 2438 - Jackson, Mississippi 1,254.0 miles None None None
Call for Information Investigational Site 2438 - Jackson, Mississippi 1,254.0 miles None None None
Call for Information Investigational Site 2746 - Hialeah, Florida 1,256.9 miles None None None
Call for Information Investigational Site 2746 - Hialeah, Florida 1,256.9 miles None None None
Call for Information Investigational Site 2746 - Hialeah, Florida 1,256.9 miles None None None
Call for Information Investigational Site 2746 - Hialeah, Florida 1,256.9 miles None None None
Call for Information Investigational Site 2746 - Hialeah, Florida 1,256.9 miles None None None
Call for Information Investigational Site 2517 - Little Rock, Arkansas 1,265.6 miles None None None
Call for Information Investigational Site 2517 - Little Rock, Arkansas 1,265.6 miles None None None
Call for Information Investigational Site 2517 - Little Rock, Arkansas 1,265.6 miles None None None
Call for Information Investigational Site 2517 - Little Rock, Arkansas 1,265.6 miles None None None
Call for Information Investigational Site 2517 - Little Rock, Arkansas 1,265.6 miles None None None
Call for Information Investigational Site 2526 - Omaha, Nebraska 1,286.1 miles None None None
Call for Information Investigational Site 2526 - Omaha, Nebraska 1,286.1 miles None None None
Call for Information Investigational Site 2526 - Omaha, Nebraska 1,286.1 miles None None None
Call for Information Investigational Site 2526 - Omaha, Nebraska 1,286.1 miles None None None
Call for Information Investigational Site 2526 - Omaha, Nebraska 1,286.1 miles None None None
Call for Information Investigational Site 2532 - Lincoln, Nebraska 1,319.2 miles None None None
Call for Information Investigational Site 2532 - Lincoln, Nebraska 1,319.2 miles None None None
Call for Information Investigational Site 2532 - Lincoln, Nebraska 1,319.2 miles None None None
Call for Information Investigational Site 2532 - Lincoln, Nebraska 1,319.2 miles None None None
Call for Information Investigational Site 2532 - Lincoln, Nebraska 1,319.2 miles None None None
Call for Information Investigational Site 2445 - Monroe, Louisiana 1,335.7 miles None None None
Call for Information Investigational Site 2445 - Monroe, Louisiana 1,335.7 miles None None None
Call for Information Investigational Site 2445 - Monroe, Louisiana 1,335.7 miles None None None
Call for Information Investigational Site 2445 - Monroe, Louisiana 1,335.7 miles None None None
Call for Information Investigational Site 2445 - Monroe, Louisiana 1,335.7 miles None None None
Call for Information Investigational Site 2407 - Hammond, Louisiana 1,352.1 miles None None None
Call for Information Investigational Site 2407 - Hammond, Louisiana 1,352.1 miles None None None
Call for Information Investigational Site 2407 - Hammond, Louisiana 1,352.1 miles None None None
Call for Information Investigational Site 2407 - Hammond, Louisiana 1,352.1 miles None None None
Call for Information Investigational Site 2407 - Hammond, Louisiana 1,352.1 miles None None None
Call for Information Investigational Site 2481 - Alexandria, Louisiana 1,405.2 miles None None None
Call for Information Investigational Site 2481 - Alexandria, Louisiana 1,405.2 miles None None None
Call for Information Investigational Site 2481 - Alexandria, Louisiana 1,405.2 miles None None None
Call for Information Investigational Site 2481 - Alexandria, Louisiana 1,405.2 miles None None None
Call for Information Investigational Site 2481 - Alexandria, Louisiana 1,405.2 miles None None None
Call for Information Investigational Site 2551 - Tyler, Texas 1,490.0 miles None None None
Call for Information Investigational Site 2551 - Tyler, Texas 1,490.0 miles None None None
Call for Information Investigational Site 2551 - Tyler, Texas 1,490.0 miles None None None
Call for Information Investigational Site 2551 - Tyler, Texas 1,490.0 miles None None None
Call for Information Investigational Site 2551 - Tyler, Texas 1,490.0 miles None None None
Call for Information Investigational Site 2441 - Dallas, Texas 1,549.9 miles None None None
Call for Information Investigational Site 2441 - Dallas, Texas 1,549.9 miles None None None
Call for Information Investigational Site 2441 - Dallas, Texas 1,549.9 miles None None None
Call for Information Investigational Site 2441 - Dallas, Texas 1,549.9 miles None None None
Call for Information Investigational Site 2441 - Dallas, Texas 1,549.9 miles None None None
Call for Information Investigational Site 2408 - Houston, Texas 1,602.8 miles None None None
Call for Information Investigational Site 2408 - Houston, Texas 1,602.8 miles None None None
Call for Information Investigational Site 2408 - Houston, Texas 1,602.8 miles None None None
Call for Information Investigational Site 2408 - Houston, Texas 1,602.8 miles None None None
Call for Information Investigational Site 2408 - Houston, Texas 1,602.8 miles None None None
Call for Information Investigational Site 2584 - Houston, Texas 1,609.9 miles None None None
Call for Information Investigational Site 2584 - Houston, Texas 1,609.9 miles None None None
Call for Information Investigational Site 2584 - Houston, Texas 1,609.9 miles None None None
Call for Information Investigational Site 2584 - Houston, Texas 1,609.9 miles None None None
Call for Information Investigational Site 2584 - Houston, Texas 1,609.9 miles None None None
Call for Information Investigational Site 2419 - Houston, Texas 1,620.8 miles None None None
Call for Information Investigational Site 2419 - Houston, Texas 1,620.8 miles None None None
Call for Information Investigational Site 2419 - Houston, Texas 1,620.8 miles None None None
Call for Information Investigational Site 2419 - Houston, Texas 1,620.8 miles None None None
Call for Information Investigational Site 2419 - Houston, Texas 1,620.8 miles None None None
Call for Information Investigational Site 2413 - Amarillo, Texas 1,724.5 miles None None None
Call for Information Investigational Site 2413 - Amarillo, Texas 1,724.5 miles None None None
Call for Information Investigational Site 2413 - Amarillo, Texas 1,724.5 miles None None None
Call for Information Investigational Site 2413 - Amarillo, Texas 1,724.5 miles None None None
Call for Information Investigational Site 2413 - Amarillo, Texas 1,724.5 miles None None None
Call for Information Investigational Site 2569 - Loveland, Colorado 1,759.6 miles None None None
Call for Information Investigational Site 2569 - Loveland, Colorado 1,759.6 miles None None None
Call for Information Investigational Site 2569 - Loveland, Colorado 1,759.6 miles None None None
Call for Information Investigational Site 2569 - Loveland, Colorado 1,759.6 miles None None None
Call for Information Investigational Site 2569 - Loveland, Colorado 1,759.6 miles None None None
Call for Information Investigational Site 2508 - San Antonio, Texas 1,767.6 miles None None None
Call for Information Investigational Site 2508 - San Antonio, Texas 1,767.6 miles None None None
Call for Information Investigational Site 2508 - San Antonio, Texas 1,767.6 miles None None None
Call for Information Investigational Site 2508 - San Antonio, Texas 1,767.6 miles None None None
Call for Information Investigational Site 2508 - San Antonio, Texas 1,767.6 miles None None None
Call for Information Investigational Site 2493 - San Antonio, Texas 1,768.2 miles None None None
Call for Information Investigational Site 2493 - San Antonio, Texas 1,768.2 miles None None None
Call for Information Investigational Site 2493 - San Antonio, Texas 1,768.2 miles None None None
Call for Information Investigational Site 2493 - San Antonio, Texas 1,768.2 miles None None None
Call for Information Investigational Site 2493 - San Antonio, Texas 1,768.2 miles None None None
Call for Information Investigational Site 2497 - Littleton, Colorado 1,771.5 miles None None None
Call for Information Investigational Site 2497 - Littleton, Colorado 1,771.5 miles None None None
Call for Information Investigational Site 2497 - Littleton, Colorado 1,771.5 miles None None None
Call for Information Investigational Site 2497 - Littleton, Colorado 1,771.5 miles None None None
Call for Information Investigational Site 2497 - Littleton, Colorado 1,771.5 miles None None None
Call for Information Investigational Site 2516 - Kerrville, Texas 1,773.7 miles None None None
Call for Information Investigational Site 2516 - Kerrville, Texas 1,773.7 miles None None None
Call for Information Investigational Site 2516 - Kerrville, Texas 1,773.7 miles None None None
Call for Information Investigational Site 2516 - Kerrville, Texas 1,773.7 miles None None None
Call for Information Investigational Site 2516 - Kerrville, Texas 1,773.7 miles None None None
Call for Information Investigational Site 2535 - Coeur d'Alene, Idaho 2,233.3 miles None None None
Call for Information Investigational Site 2535 - Coeur d'Alene, Idaho 2,233.3 miles None None None
Call for Information Investigational Site 2535 - Coeur d'Alene, Idaho 2,233.3 miles None None None
Call for Information Investigational Site 2535 - Coeur d'Alene, Idaho 2,233.3 miles None None None
Call for Information Investigational Site 2535 - Coeur d'Alene, Idaho 2,233.3 miles None None None
Call for Information Investigational Site 2539 - Tucson, Arizona 2,281.0 miles None None None
Call for Information Investigational Site 2539 - Tucson, Arizona 2,281.0 miles None None None
Call for Information Investigational Site 2539 - Tucson, Arizona 2,281.0 miles None None None
Call for Information Investigational Site 2539 - Tucson, Arizona 2,281.0 miles None None None
Call for Information Investigational Site 2539 - Tucson, Arizona 2,281.0 miles None None None
Call for Information Investigational Site 2433 - Las Vegas, Nevada 2,380.5 miles None None None
Call for Information Investigational Site 2433 - Las Vegas, Nevada 2,380.5 miles None None None
Call for Information Investigational Site 2433 - Las Vegas, Nevada 2,380.5 miles None None None
Call for Information Investigational Site 2433 - Las Vegas, Nevada 2,380.5 miles None None None
Call for Information Investigational Site 2433 - Las Vegas, Nevada 2,380.5 miles None None None
Call for Information Investigational Site 2498 - El Cajon, California 2,570.7 miles None None None
Call for Information Investigational Site 2498 - El Cajon, California 2,570.7 miles None None None
Call for Information Investigational Site 2498 - El Cajon, California 2,570.7 miles None None None
Call for Information Investigational Site 2498 - El Cajon, California 2,570.7 miles None None None
Call for Information Investigational Site 2498 - El Cajon, California 2,570.7 miles None None None
Call for Information Investigational Site 2576 - San Diego, California 2,579.1 miles None None None
Call for Information Investigational Site 2576 - San Diego, California 2,579.1 miles None None None
Call for Information Investigational Site 2576 - San Diego, California 2,579.1 miles None None None
Call for Information Investigational Site 2576 - San Diego, California 2,579.1 miles None None None
Call for Information Investigational Site 2576 - San Diego, California 2,579.1 miles None None None
Call for Information Investigational Site 2479 - Torrance, California 2,606.2 miles None None None
Call for Information Investigational Site 2479 - Torrance, California 2,606.2 miles None None None
Call for Information Investigational Site 2479 - Torrance, California 2,606.2 miles None None None
Call for Information Investigational Site 2479 - Torrance, California 2,606.2 miles None None None
Call for Information Investigational Site 2479 - Torrance, California 2,606.2 miles None None None
Call for Information Investigational Site 2470 - Sacramento, California 2,628.2 miles None None None
Call for Information Investigational Site 2470 - Sacramento, California 2,628.2 miles None None None
Call for Information Investigational Site 2470 - Sacramento, California 2,628.2 miles None None None
Call for Information Investigational Site 2470 - Sacramento, California 2,628.2 miles None None None
Call for Information Investigational Site 2470 - Sacramento, California 2,628.2 miles None None None

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