Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep


This study aims to determine whether, compared with placebo, the nighttime administration of a intravenous dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in extubated post-cardiac surgical patients.

Study Start Date

March, 06 2017

Estimated Completion Date

June 2020


  • Drug: Dexmedetomidine
  • Drug: Placebo

Study ID

Massachusetts General Hospital -- 2016P000742



Trial ID


Study Type


Trial Phase

Phase 2/Phase 3

Enrollment Quota



Massachusetts General Hospital

Inclusion Criteria

  • Age ? 60
  • Scheduled for a cardiac surgical procedure with planned post-operative admission to the CSICU for ? 24 hours
  • Scheduled same day surgical admission

Exclusion Criteria

  • Blind, deafness or the inability to speak English
  • Greater than 2 days of ICU admission in the month preceding the current surgical procedure
  • Renal and liver failure requiring dialysis or Child-Pugh score > 5
  • Follow-up difficulties (i.e. active substance abuse, psychotic disorder, homelessness)
  • Previous cardiac surgery within 1 year of surgical procedure
  • Allergy to dexmedetomidine
  • Chronic therapy with benzodiazepines and/or antipsychotics
  • Severe deficit due to structural or anoxic brain damage
  • Surgical procedure requiring total circulatory arrest Objective Drop Criteria
  • Scheduled for a second surgical procedure during hospital stay
  • Post-operative intubation > 12 hours




60 Years and older

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles Oluwaseun JohnsonAkeju MDMMSc 617-724-7200 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.