Efficacy of Intravenous Lidocaine in the Operative Management of Thyroid Surgery With Intraoperative Nerve Monitoring


Intra operative Nerve Monitoring ( IONM ) is rapidly becoming the standard of care for thyroid surgery to prevent injury to the recurrent laryngeal nerve. However the laryngo tracheal reflexes need to be adequately suppressed to permit proper utilization of intra operative nerve monitoring. Increasing the depth of anesthesia to achieve this often leads to side effects. Intravenous lidocaine infusion has been shown to be effective in blunting these reflexes. The planned study intends to look at the efficacy of intravenous lidocaine infusion in decreasing the amount of anesthesia medications needed to suppress the reflexes. Also the study looks at the analgesic and anti emetic properties of intravenous lidocaine infusion post operatively by measuring these outcomes. The study is designed as a double blinded randomized controlled trial with 30 subjects in the group who will receive intravenous lidocaine during surgery and 30 subjects in the group who will receive placebo. Blunting of the laryngo tracheal reflexes intra operatively will be recorded as the primary outcome. The amount of anesthesia medications, the post operative patient comfort level, pain control, usage of narcotic pain medications, nausea, vomiting will be recorded as secondary outcomes.

Study Start Date

June 2015

Estimated Completion Date

December 2016


  • Drug: Placebo
  • Drug: Lidocaine


  • Surgery: Endocrine
  • Endocrinology: Thyroid/Parathyroid
  • Anesthesiology: Perianesthesia Monitoring,Pharmacology/kinetics

MeSH Terms

  • Anesthetics
  • Central Nervous System Depressants
  • Lidocaine

Study ID

Bronx-Lebanon Hospital Center Health Care System -- 04091501



Trial ID


Study Type


Trial Phase

Phase 4

Enrollment Quota



Bronx-Lebanon Hospital Center Health Care System

Inclusion Criteria

  • Consenting patients undergoing bilateral thyroid surgery
  • Age
  • 18-80 y

Exclusion Criteria

  • Patients undergoing additional procedures,
  • Patients younger than 18y or older than 80 years.
  • Patients at high risk for use of lidocaine due to Congestive heart failure, arrhythmia.




18 Years to 80 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Health and Wellness Center Bronx Lebanon Hospital Center - Bronx, New York 42.6 miles Ajay Shah MD FACS 347-820-1560 ajashah@bronxleb.org

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