Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis

Description

The purpose of this study is to assess if administration of an early single dose of a diuretic (furosemide) to children with moderate to severe bronchiolitis can reduce extravascular lung water in an effort to reduce respiratory rate, retractions, intubations, and length of stay.

Study Start Date

October 2013

Estimated Completion Date

April 2016

Interventions

  • Drug: Furosemide
  • Drug: Placebo

Specialties

  • Internal Medicine: Infectious Disease,Pulmonology
  • Nursing: Immuno/Infectious Dz,Pulmonology
  • Infectious Disease: Pulm/Thoracic Infections
  • Pulmonology: COPD,Pulm/Thoracic Infections

MeSH Terms

  • Bronchial Diseases
  • Bronchiolitis
  • Furosemide
  • Lung Diseases, Obstructive
  • Respiratory Tract Infections

Study ID

North Shore Long Island Jewish Health System -- 12-260B

Status

Unknown

Trial ID

NCT02469597

Study Type

Interventional

Trial Phase

Phase 2

Enrollment Quota

100

Sponsor

North Shore Long Island Jewish Health System

Inclusion Criteria

  • Diagnosis of Acute Bronchiolitis
  • Admission required per Emergency Department Physician

Exclusion Criteria

  • No legal guardian present
  • Sulfa allergy
  • Patient currently on existing diuretic therapy
  • Tracheostomy
  • Mild respiratory distress (not requiring admission)
  • Hypotension / Hemodynamic Instability (defined by age specific criteria at time of intervention)
  • Supplemental Oxygen at home
  • History of Dialysis / Renal Disease
  • Those enrolled in another drug interventional study

Gender

Both

Ages

48 Months and younger

Accepts Healthy Volunteers

No

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Steven and Alexandra Cohen Childrens Medical Center of New York - New Hyde Park, New York 39.6 miles Kristy A Williamson MD 202-321-3586 kwilliam12@nshs.edu

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