Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis


The purpose of this study is to assess if administration of an early single dose of a diuretic (furosemide) to children with moderate to severe bronchiolitis can reduce extravascular lung water in an effort to reduce respiratory rate, retractions, intubations, and length of stay.

Study Start Date

October 2013

Estimated Completion Date

April 2016


  • Drug: Furosemide
  • Drug: Placebo


  • Internal Medicine: Infectious Disease,Pulmonology
  • Nursing: Immuno/Infectious Dz,Pulmonology
  • Infectious Disease: Pulm/Thoracic Infections
  • Pulmonology: COPD,Pulm/Thoracic Infections

MeSH Terms

  • Bronchial Diseases
  • Bronchiolitis
  • Furosemide
  • Lung Diseases, Obstructive
  • Respiratory Tract Infections

Study ID

North Shore Long Island Jewish Health System -- 12-260B



Trial ID


Study Type


Trial Phase

Phase 2

Enrollment Quota



North Shore Long Island Jewish Health System

Inclusion Criteria

  • Diagnosis of Acute Bronchiolitis
  • Admission required per Emergency Department Physician

Exclusion Criteria

  • No legal guardian present
  • Sulfa allergy
  • Patient currently on existing diuretic therapy
  • Tracheostomy
  • Mild respiratory distress (not requiring admission)
  • Hypotension / Hemodynamic Instability (defined by age specific criteria at time of intervention)
  • Supplemental Oxygen at home
  • History of Dialysis / Renal Disease
  • Those enrolled in another drug interventional study




48 Months and younger

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Steven and Alexandra Cohen Childrens Medical Center of New York - New Hyde Park, New York 39.6 miles Kristy A Williamson MD 202-321-3586 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.