Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions


Borderline Personality Disorder (BPD), a prevalent psychiatric disorder found in approximately 2% to 6% of the population and 20% of hospitalized psychiatric patients, has proven quite treatment resistant. This study is designed to determine whether patients with BPD can be trained to improve their ability to regulate their emotions and whether this leads to changes in how their brans regulate emotion.

Study Start Date

September 2011

Estimated Completion Date

May 2016


  • Behavioral: Reappraisal Training


  • Internal Medicine: Psychiatry
  • Nursing: Mental Health
  • Psychiatry: Personality Disorders
  • Family Medicine: Psychiatry
  • Physician Assistant: Psychiatry

MeSH Terms

  • Borderline Personality Disorder
  • Mental Disorders
  • Personality Disorders

Study ID

Mount Sinai School of Medicine -- GCO 05-1110



Trial ID


Study Type


Trial Phase


Enrollment Quota



Mount Sinai School of Medicine

Inclusion Criteria

  • BPD subjects 18 to 50 years old
  • Meet criteria for DSM-IV Borderline Personality Disorder, including the DSM-IV criteria for affective instability (criterion #6), and not meet criteria for Schizotypal Personality Disorder (SPD) or AvPD.
  • Subjects in the AvPD group meet DSM-IV criteria for AvPD and not for BPD or SPD.
  • All subjects will be free of psychotropic medications for 2 weeks (6 weeks for fluoxetine).
  • Subjects may be enrolled in psychotherapy

Exclusion Criteria

  • BPD and AvPD subjects will not meet DSM-IV criteria for past or present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance dependence, head trauma, CNS neurological disease, seizure disorder or current major depression.
  • Substance abuse disorder in the prior 6 months
  • Significant medical illness
  • Pregnancy
  • Metallic foreign-bodies that contraindicate MRI




18 Years to 55 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Icahn School of Medicine at Mount Sinai - New York, New York 46.8 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.