Trial of Verapamil in Chronic Rhinosinusitis


Verapamil is an L-type calcium channel blocker(CCB) which has been shown to reduce inflammation in a variety of tissues. Verapamil has also been shown to improve eosinophilic inflammation in an animal model of asthma and also functions as a P-glycoprotein(P-gp) inhibitor. A major subtype of chronic rhinosinusitis(CRS) is characterized by eosinophilic inflammation as well as P-gp overexpression. The goal of this study is to therefore see whether Verapamil may be used to treat CRS.

Study Start Date

May 2015

Estimated Completion Date

May 2019


  • Drug: Verapamil HCl
  • Other: Placebo


  • Allergy/Immunology: Cardiovascular/Pulm
  • Pharmacy: Drug Trials
  • Otolaryngology: Nose,Sinus
  • Physician Assistant: ENT

MeSH Terms

  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Nasal Polyps
  • Nose Diseases
  • Otorhinolaryngologic Diseases
  • Verapamil

Study ID

Massachusetts Eye and Ear Infirmary -- 15-009H



Trial ID


Study Type


Trial Phase


Enrollment Quota



Massachusetts Eye and Ear Infirmary

Inclusion Criteria

    1. Patients presenting to the MEEI Sinus Center 2. Age 18-80 yrs old 3. Diagnosed with Chronic Rhinosinusitis with Nasal Polyps according to the EPOS 2012 consensus criteria

Exclusion Criteria

    1. Patients with the following comorbidities:
  • GI Hypomotility
  • Heart Failure
  • Liver Failure
  • Kidney Disease
  • Muscular Dystrophy
  • Pregnant or Nursing Females
  • Steroid Dependency 2. Patients taking the following medications:
  • Aspirin
  • Beta-blockers
  • Cimetidine(Tagamet)
  • Clarithromycin(Biaxin)
  • Cyclosporin
  • Digoxin
  • Disopyramide(Norpace)
  • Diuretics
  • Erythromycin
  • Flecainide
  • HIV Protease Inhibitors(Indinavir, Nelfinavir, Ritonavir)
  • Quinidine
  • Lithium
  • Pioglitazone
  • Rifampin
  • St Johns Wort 3. Patients with cardiac or conduction abnormality picked up by screening EKG




18 Years to 80 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Massachusetts Eye and Ear Infirmary - Boston, Massachusetts 2.8 miles Marcel M Miyake MD 617-794-3627 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.