Establishment of Functional MRI Imaging Parameters for Use in the Evaluation of Sickle Cell Disease

Description

Patients with sickle cell anemia (SCA) are at an increased risk for damage to brain tissue due to their disease. The investigators are interested in how blood flow and cerebral inflammation are different in SCA patients and how that affects brain tissue- the investigators will use a relatively new set of dynamic MRI techniques to evaluate these parameters. The investigators will image participants with both SCA and matched controls with non-invasive MRI.

Study Start Date

November 2014

Estimated Completion Date

May 2016

Interventions

No interventions cited

Specialties

  • Internal Medicine: Hematology/Oncology,Radiology/Diagnostics
  • Oncology: Anemia/Polycythemia,Diagnostics/Radiology
  • Radiology: MRI
  • Physician Assistant: Hematology/Oncology,Radiology

MeSH Terms

  • Anemia, Hemolytic
  • Anemia, Sickle Cell

Study ID

Albert Einstein College of Medicine of Yeshiva University -- 2014-3574

Status

Unknown

Trial ID

NCT02445144

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

30

Sponsor

Albert Einstein College of Medicine of Yeshiva University

Inclusion Criteria

  • Patient with HbSS/HbSB0,
  • age between 18 and 55 years or age/gender/race/education matched peer

Exclusion Criteria

  • Previous history of a stroke/transient ischemic attack,
  • neurosurgery,
  • head trauma,
  • seizures,
  • pulmonary embolism,
  • deep-vein thrombosis,
  • bleeding/clotting disorders,
  • current or previous use of anticoagulation medications

Gender

Both

Ages

18 Years to 55 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
Montefiore Medical Center Einstein - Bronx, New York 40.3 miles None None None
Albert Einstein College of Medicine - Bronx, New York 40.3 miles None None None

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