The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study

Description

The purpose of this project is to examine brain function before, during, and after the administration of tDCS (Transcranial Direct Current Stimulation). The brain can perform its job well or poorly depending on many things. The investigators will be using computer tasks and paper and pencil questionnaires to measure the relationship between brain performance and the administration of tDCS. In addition, the study team will be using functional magnetic resonance imaging (fMRI) and related imaging techniques to see how your brain works and compare it with the results we collected from the paper and pencil questionnaires. This study will enroll both schizophrenia patients as well as healthy volunteers without any major psychiatric disorder or physical illness.

Study Start Date

April 2015

Estimated Completion Date

April 2017

Interventions

  • Device: Transcranial direct current stimulation - Sham
  • Device: Transcranial direct current stimulation

Specialties

  • Nursing: Mental Health
  • Psychiatry: Schizophrenia/Psychosis
  • Physician Assistant: Psychiatry

MeSH Terms

  • Schizophrenia
  • Schizophrenia

Study ID

North Shore Long Island Jewish Health System -- 14-623

Status

Unknown

Trial ID

NCT02421146

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

80

Sponsor

North Shore Long Island Jewish Health System

Inclusion Criteria

    1. Between 18 and 60 years of age 2. Subject is competent to provide informed consent Additional inclusion criteria for schizophrenia group: 3. Pt diagnosed with schizophrenia according to DSM V criteria.

Exclusion Criteria

    1. MRI contraindications 2. Person with any kind of neurostimulator or pacemaker, or built in electrical device even if it is MRI safe 3. Skin lesions at the site of electrodes and any documented head or neck dermatological disorder 4. Pregnancy 5. Any major neurological (seizures, sclerosis multiplex, etc) disorder 6. Individuals who are illiterate and/or visually impaired 7. Subjects with history of mental retardation, learning disorders or traumatic brain injury Additional exclusion criteria for healthy group: 8. Past or current history of any psychotic illness in the subject or in first degree family members 9. Self report of illicit drug use (except marijuana) in the past. Use of marijuana during the last 3 month. 10. Any use of any psychotropic medications (antipsychotics, SSRI, mood stabilizers, benzodiazepines, stimulants) in the last month.

Gender

Both

Ages

18 Years to 60 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Zucker Hillside Hospital - Glen Oaks, New York 40.7 miles Miklos Argylen md 718-470-8175 margyela@nshs.edu

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