Role of Glucagon In Glucose Control in Cystic Fibrosis Related Diabetes

Description

This project is designed to begin to characterize the abnormalities of glucagon secretion in subjects with cystic fibrosis related diabetes along the spectrum of glucose tolerance. Cystic fibrosis patients with normal glucose tolerance as well as cystic fibrosis related diabetes as well as control subjects will undergo an oral glucose tolerance test, mixed meal tolerance test, and one step hypoglycemic clamp. Cystic fibrosis patients will then return 12 months later to undergo repeat mixed meal tolerance test and hypoglycemic clamp test.

Study Start Date

March 2015

Estimated Completion Date

January 2018

Interventions

  • Other: Mixed Meal Tolerance Test
  • Other: Oral Glucose Tolerance Test
  • Other: Hypoglycemic Clamp

Specialties

  • Nursing: Pulmonology
  • Pulmonology: Cystic Fibrosis
  • Endocrinology: Diabetes

MeSH Terms

  • Cystic Fibrosis,Fibrosis

Study ID

Yale University -- 1409014580

Status

Unknown

Trial ID

NCT02398383

Study Type

Interventional

Trial Phase

Phase 0

Enrollment Quota

30

Sponsor

Yale University

Inclusion Criteria

  • Diagnosis of CF by clinical or genetic determination
  • Normal glucose tolerance or CFRD
  • Subjects routinely taking systemic or inhaled glucocorticoids on stable regimen are eligible

Exclusion Criteria

  • Subjects with active pulmonary infection requiring supplemental doses of corticosteroids
  • Use of any oral diabetes medications
  • Subjects who are pregnant/lactating
  • Subjects with poor compliance with pancreatic enzyme replacement therapy Control Subjects: Approximately 10 control subjects who are matched for age, gender, are expected to be enrolled in the study. Non-CF subjects must be >12 years old, in good health and not taking any medications or have any medical problems the doctor feels would prevent the subject from completing the study and have BMI between 15-85% for age and gender. Control subjects whose fasting blood glucose is found to be >110 mg/dL will not be continued in the study.

Gender

Both

Ages

12 Years to 45 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Yale New Haven Hospital - New Haven, Connecticut 18.0 miles None None None

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