Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer With History of Bone Fracture


This research study is evaluating bone mineral density in childhood cancer survivors who have a history of bone fracture.

Study Start Date

May 2015

Estimated Completion Date

June 2018


  • Other: Peripheral quantitative computed tomography (pQCT)
  • Other: Dual energy x-ray absorptiometry (DXA)


  • Emergency Medicine: Orthopedics/Sports Med
  • Orthopedics: Trauma
  • Physician Assistant: Emergency/Trauma

MeSH Terms

  • Fractures, Bone

Study ID

Dana-Farber Cancer Institute -- 14-411



Trial ID


Study Type


Trial Phase


Enrollment Quota



Dana-Farber Cancer Institute

Inclusion Criteria

  • History of childhood cancer
  • Age ? 8 years and < 20 years at time of enrollment
  • ? 2 years since completion of cancer-directed therapy for first cancer
  • Received chemotherapy for treatment of childhood cancer
  • History of bone fracture after the conclusion of chemotherapy*
  • Not currently receiving cancer-directed therapy
  • Signed written informed consent (by parent if patient is < 18 years of age, or by patient, if he or she is ?18 years of age)
  • Patient assent for those ?10 years of age and < 18 years of age for whom a parent provides informed consent (*History of bone fracture will be based on patient/parent report of fracture occurrence and will be confirmed in review of the medical record whenever feasible.)

Exclusion Criteria

  • Current treatment with bisphosphonates (as of time of enrollment)
  • Current treatment with the anticonvulsant depakote (at time of enrollment)
  • Currently pregnant




8 Years to 20 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
Dana Farber Cancer Institute - Boston, Massachusetts 2.6 miles Lynda Vrooman MD 617-632-2659
Boston Childrens Hospital - Boston, Massachusetts 2.6 miles Lynda Vrooman MD 617-632-2659 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.