The Effects of Head Trauma on Collegiate Athletes
Recently, researchers and clinicians have examined many different forms of concussion testing aimed to assess if a brain injury has occurred and to what degree it affects the individual being tested. Due to the multifaceted and complex presentation of concussive injuries and the unknown effects of repeated head trauma, it is unlikely that a single test of physiological or behavioral function will reflect the full range of injury-related damages from a concussive event or from a series of cumulative head traumas, as well as the injury response within brain tissue. However, by combining a variety of objective assessments which may detect structural and functional alterations following head trauma into a single study, a clearer understanding of the multi-faceted presentation resulting from head trauma may be identified. The identification of biomarkers and the utilization of objective and clinically feasible tools will provide a method to assess three domains across multiple systems affected by head trauma: 1) the prognostic value of initial concussion assessments to identify injury severity and factors responsible for prolonged recovery, 2) the temporal window of recovery and potential vulnerability of brain tissue post-injury, and 3) the long-term alterations associated with repeated head trauma exposure.
Study Start Date
Estimated Completion Date
No interventions cited
- Neurology: Trauma
- Family Medicine: Sports Medicine
- Emergency Medicine: Neurology/Neurosurgery,Trauma
- Brain Concussion
- Brain Injuries
- Craniocerebral Trauma
Children's Hospital Boston -- IRB-P00016469
Children's Hospital Boston
1. Participation on a Harvard University varsity athletic team
2. Medically cleared to participate in sport, as determined by Harvard medical staff
3. Diagnosed with concussion by Harvard medical staff, and agreement to participate in
the post-injury component of the study within five days of injury (post-concussion
4. No diagnosed concussion within the previous year of evaluation (control group)
1. A history of epilepsy, prior seizure, or any previous abnormal EEG finding or
abnormal brain imaging (CT or MRI) finding, as reported by the patient.
2. Any pre-existing neurological disorder, including but not limited to stroke,
intracranial hemorrhage, any movement disorder, and cerebral palsy.
3. Any currently active psychiatric condition, including specifically major depression,
bipolar disorder or schizophrenia. A history of a psychiatric condition but no
ongoing psychiatric episode (e.g. not currently undergoing treatment for a major
depressive episode) would not be an exclusion.
4. Any unstable medical condition
5. For the transcranial Doppler ultrasound component of the study only, subjects with
infection, history of seizure, cardioactive drug participation, presence of deep vein
thrombosis, cervical injury (structural or vascular), gross motor deficits, or skull
fractures will be excluded.
18 Years to 25 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Study Locations and Contact Information (1)
|Boston Childrens Hospital - Boston, Massachusetts||2.6 miles||David Howell||781-216-2865||David.Howell2@childrens.harvard.edu|