Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis


The objective of this study is to evaluate the potential of Topicort® (desoximetasone) Topical Spray, 0.25% to suppress hypothalmic pituitary adrenal axis function. The secondary objectives are to evaluate the efficacy parameters, pharmacokinetics and adverse event profile.

Study Start Date

December 2014

Estimated Completion Date

April 2016


  • Drug: Topicort® (desoximetasone) Topical Spray, 0.25%
  • Drug: Topicort® (desoximetasone) Topical Spray, 0.25%


  • Pharmacy: Antimicrobials
  • Dermatology: Clinical Pharmacology,Psoriasis
  • Physician Assistant: Dermatology

MeSH Terms

  • Plaque Psoriasis
  • Psoriasis

Study ID

Taro Pharmaceuticals USA -- DSXS-1303



Trial ID


Study Type


Trial Phase

Phase 4

Enrollment Quota



Taro Pharmaceuticals USA

Inclusion Criteria

  • Patients aged 7 years and older must have provided written assent accompanied by written informed consent from patient's representative
  • Clinical diagnosis of stable plaque psoriasis with involvement of ? 10% body surface area (excluding face and scalp)
  • Physicians Global Assessment score of 3 or 4 at baseline

Exclusion Criteria

  • Has other dermatological conditions that may interfere with clinical assessments
  • Allergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results
  • History of an adverse reaction to Cortrosyn™ or similar test reagents
  • Chronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation




2 Years to 17 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Taro Pharmaceuticals USA Inc - Hawthorne, New York 29.6 miles Natalie Yantovskiy None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.