GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration
The investigators plan to explore the effects of acute pre-treatment with the glucagon like peptide-1 (GLP-1) agonist, exenatide versus placebo, on the subjective (e.g., euphoric) and behavioral effects (e.g., self-administration) of cocaine in experienced, non-treatment seeking users of the drug. Additionally, the investigators plan to explore the effects of sub-chronic (5-day) treatment with exenatide as compared to placebo on the subjective (e.g., euphoric) and behavioral (self-administration) effects of cocaine in experienced, non-treatment seeking users of the drug.
Study Start Date
Estimated Completion Date
- Drug: exenatide
- Drug: placebo
- Drug: cocaine hydrochloride
- Family Medicine: Substance Abuse
- Nurse Practitioner: Substance Abuse
- Cocaine Dependence
Yale University -- 1409014655
1. age 18
- 50 years, 2. voluntary, written, informed consent, 3. physically healthy by medical history, physical, neurological, ECG, and laboratory examinations, 4. DSM-IV criteria for Cocaine Abuse (305.60) or Cocaine Dependence (304.20) 5. recent street cocaine use in excess of amounts to be administered in the current study, 6. intravenous and/or smoked (crack/ freebase) use, 7. positive urine toxicology screen for cocaine, 8. for females, non-lactating, no longer of child-bearing potential (or agree to practice effective contraception during the study), and a negative serum pregnancy (?-HCG) test.
1. Other drug dependence (except nicotine) as determined by urine toxicology or
2. < 1 year of cocaine dependence,
3. a primary major DSM-IV psychiatric diagnosis (schizophrenia, bipolar disorder, etc.),
unrelated to cocaine,
4. a history of significant medical (cardiovascular) or neurological illness, ie prior
myocardial infarction, current active symptoms of cardiovascular disease / angina,
evidence of cocaine-related cardiovascular symptoms, prior arrhythmias or need for
cardiovascular resuscitation, neurovascular events such as transient ischemic
attacks, stroke, and/or seizures Parameters re: elevations in vital signs are now
explicitly specified under "Safety features built into our one-day
5. current use of psychotropic and/or potentially psychoactive prescription medication,
6. seeking treatment for drug abuse/dependence (for experimental cocaine component),
7. physical or laboratory (?-HCG) evidence of pregnancy.
8. current use of any medication (prescription or over-the-counter) determined to cause
potential drug interactions by the study physicians.
18 Years to 50 Years
Accepts Healthy Volunteers
Study Locations and Contact Information (1)
|Connecticut Mental Health Center - New Haven, Connecticut||17.3 miles||Edward Gaiser BAemail@example.com|