The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)


Total knee replacement is associated with severe post-operative pain. The purpose of this study is to compare two methods of treatment for pain control following Total Knee Replacement with an accelerated physical therapy protocol to aid the achievement of rehab milestones.

Study Start Date

November 2014

Estimated Completion Date

June 2016


  • Drug: Midazolam
  • Device: 8 MHz. Chiba needle, 22 G / 4 inches
  • Drug: Bupivacaine
  • Drug: Normal saline
  • Drug: Dexamethasone
  • Drug: Morphine
  • Drug: Cefazolin
  • Drug: Methylprednisolone
  • Drug: Propofol


  • Rheumatology: Osteoarthritis
  • Anesthesiology: Pain Management
  • Orthopedics: Knee,Surgical Technique

MeSH Terms

  • Osteoarthritis
  • Propofol

Study ID

Hospital for Special Surgery, New York -- 2014-018



Trial ID


Study Type


Trial Phase

Phase 4

Enrollment Quota



Hospital for Special Surgery, New York

Inclusion Criteria

  • Patients with osteoarthritis scheduled for primary tricompartmental total knee arthroplasty with a participating surgeon
  • Age 18 to 80 years
  • Planned use of regional anesthesia
  • Ability to follow study protocol
  • English speaking (secondary outcomes include questionnaires validated in English only)

Exclusion Criteria

    Hepatic or renal insufficiency Patients younger than 18 years old and older than 80 Patients intending to receive general anesthesia Patients planning to go to rehab post operatively Patients scheduled to go into the OR after 12 pm Allergy or intolerance to one of the study medications Patients with an ASA of IV Chronic gabapentin/pregabalin use (regular use for longer than 3 months) Chronic opioid use (taking opioids for longer than 3 months) Diabetes Patients on workers compensation or disability




18 Years to 80 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Hospital for Special Surgery - New York, New York 48.5 miles Enrique Goytizolo MD 212-606-1036 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.