SYN120 a Dual 5-HT6/5-HT2A Antagonist Proof of Concept Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE)


The purpose of this study placebo-controlled, randomized, double-blind study is to assess the safety and efficacy of SYN120 in patients with Parkinson's disease dementia (PDD) already treated with a stable dose of a cholinesterase inhibitor.

Study Start Date

December 2014

Estimated Completion Date

December 2016


  • Drug: SYN120
  • Drug: Placebo


  • Neurology: Movement Disorders
  • Physician Assistant: Neurology

MeSH Terms

  • Dementia
  • Parkinson Disease
  • SYN120

Study ID

Biotie Therapies Inc. -- SYN120-CL03



Trial ID


Study Type


Trial Phase

Phase 2

Enrollment Quota



Biotie Therapies Inc.

Inclusion Criteria

  • Parkinson's Disease Dementia
  • Patient has a routine caregiver
  • Taking a stable cholinesterase inhibitor.
  • Patient has a Montreal Cognitive Assessment (MoCA) 10-23 inclusive

Exclusion Criteria

  • History of any significant neurologic or psychiatric disease other than PD
  • Any other condition or clinically significant abnormal findings that would make the patient unsuitable for the study
  • Unpredictable motor fluctuations that would interfere with administering assessments




50 Years and older

Accepts Healthy Volunteers


Study Locations and Contact Information (12)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles Grace Bwala 617-643-0654
Parkinsons Disease Movement Disorder Center - Philadelphia, Pennsylvania 269.5 miles Eugenia Mamikonyan 215-615-3085
Department of Neurology University of Maryland Parkinsons Disease Movement Disorder Center - Baltimore, Maryland 358.9 miles Michelle Cines RNMDCRCC 410-328-0157
Medical University of South Carolina - Charleston, South Carolina 821.2 miles Shonna Jenkins 843-732-9115
Northwestern University Feinberg School of Medicine - Chicago, Illinois 847.9 miles Karen Williams 312-503-0755
Rush University Medical Center - Chicago, Illinois 851.3 miles Lucia Blasucci RN 312-563-2900
University of Iowa Carver College of Medicine - Iowa City, Iowa 1,048.9 miles Jeri Sieren 319-356-8744
The University of Alabama at Birmingham - Birmingham, Alabama 1,052.1 miles Ashlee Rawlins RN 205-975-2894
Parkinsons Disease Movement Disorder Center of Boca Raton - Boca Raton, Florida 1,221.8 miles Fannie Levinson 561-392-1818
Parkinsons Disease Movement Disorder Center University of Kansas Medical Center - Kansas City, Kansas 1,277.1 miles April Langhammer BACCRP 913-588-6989
Baylor Univeristy - Houston, Texas 1,609.9 miles Farah Ismail 713-798-6902
UC San Diego - La Jolla, California 2,583.7 miles Lisette Moreno 858-822-1399 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.