Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study

Description

The investigators propose to examine both resting state activity and functional activity during rumination and during self-processing to study the relationship between neural correlates of rumination/self-focus and self-processing in major depression and bipolar disorder.

Study Start Date

January 2013

Estimated Completion Date

November 2016

Interventions

  • Other: Functional Magnetic Resonance Imaging (fMRI)

Specialties

  • Nursing: Mental Health
  • Psychiatry: Anxiety,Mood Disorders
  • Family Medicine: Psychiatry
  • Radiology: MRI

MeSH Terms

  • Bipolar Disorder
  • Depression
  • Functional Magnetic Resonance Imaging
  • Major

Study ID

Massachusetts General Hospital -- 2012P000714

Status

Unknown

Trial ID

NCT02253225

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

60

Sponsor

Massachusetts General Hospital

Inclusion Criteria Healthy Controls:
  • Right-handed (as determined by the Handedness Inventory
  • Oldfield, 1971)
  • Normal or corrected-to normal vision and hearing Exclusion Criteria for Healthy Controls:
  • Any current or past psychiatric history
  • Significant medical, psychiatric or neurological illness
  • Currently taking antidepressants, mood stabilizers, or benzodiazepines
  • Positive MR screen (e.g., metal implant, claustrophobia, etc) Inclusion Criteria for Patients with Major Depression:
  • Current diagnosis of MDD
  • Right-handed (as determined by the Handedness Inventory
  • Oldfield, 1971)
  • Normal or corrected-to normal vision and hearing Exclusion Criteria for MDD Patients:
  • If a history of substance abuse, at least 6 months in remission
  • Current suicidal ideation or history of suicide attempts
  • Positive MR screen (e.g., metal implant, claustrophobia, etc) Inclusion Criteria for patients with BPAD:
  • Current diagnosis of BPAD
  • Right-handed (as determined by the Handedness Inventory
  • Oldfield, 1971)
  • Normal or corrected-to normal vision and hearing Exclusion Criteria for BPAD Patients:
  • If a history of substance abuse, at least 6 months in remission
  • Current suicidal ideation or history of suicide attempts
  • Positive MR screen (e.g., metal implant, claustrophobia, etc)
  • Gender

    Both

    Ages

    18 Years to 64 Years

    Accepts Healthy Volunteers

    Accepts Healthy Volunteers

    Study Locations and Contact Information (1)

    Study Location Distance Name Phone Email
    Massachusetts General Hospital - Boston, Massachusetts 2.8 miles Casey Hearing 617-726-7591 chearing@mgh.harvard.edu

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