Study of the Intravitreal Implantation of NT-503-3 Encapsulated Cell Technology (ECT) for the Treatment of Recurrent Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)


Prospective, multi-center 2-stage study. Stage 1 (Phase I) is open-label with all patients treated with the NT-503-3 ECT implant. Stage 1 (Phase I) patients will undergo explantation at year 2. Those who, in the opinion of the investigator, are still candidates for continued anti-VEGF therapy will be re-implanted with a new NT-503-3 investigational product and followed for an additional 12 weeks before study exit. Stage 2 (Phase II) is a separate, randomized, masked phase during which eligible patients will be randomized to the NT-503-3 group or the control group. Clinical Hypotheses: - NT-503-3 ECT is comparable to Eylea® injected intravitreally every 8 weeks in the prevention of vision loss due to recurrent CNV secondary to AMD - NT-503-3 ECT has an acceptable safety profile

Study Start Date

September 2014

Estimated Completion Date

March 2018


  • Drug: Eylea® injected intravitreally administered every 8 weeks
  • Drug: NT-503-3 ECT implantation
  • Drug: Eylea® injected intravitreally administered every 8 weeks


  • Ophthalmology: Retina
  • Physician Assistant: Ophthalmology

MeSH Terms

  • Choroidal Neovascularization
  • Eye Diseases
  • Macular Degeneration
  • Retinal Degeneration

Study ID

Neurotech Pharmaceuticals -- NT-503-3-AMD-001



Trial ID


Study Type


Trial Phase

Phase 1/Phase 2

Enrollment Quota



Neurotech Pharmaceuticals


Inclusion Criteria

  • Diagnosis of Active (recurrent or persistent) subfoveal CNV lesions secondary to AMD in one eye
  • Prior Intravitreal Anti-VEGF injections Key

Exclusion Criteria

  • Significant subretinal hemorrhage
  • Significant Scar and/or, fibrosis
  • Suspected retinal angiomatous proliferation (RAP) or polypoidal choroidopathy, or pigment epithelial tears or rips




50 Years and older

Accepts Healthy Volunteers


Study Locations and Contact Information (32)

Study Location Distance Name Phone Email
Ophthalmic Consultants of Boston - Boston, Massachusetts 2.8 miles Jeffrey S Heier MD 617-367-4800
Retina Center of New Jersey LLC - Bloomfield, New Jersey 192.8 miles Patrick Higgins MD 973-707-5632
NJ Retina - New Brunswick, New Jersey 217.0 miles Daniel B Roth MD None
Mid Atlantic Retina - Philadelphia, Pennsylvania 269.5 miles Allen Ho MD 215-928-3095
The Retina Group of Washington - Chevy Chase, Maryland 391.7 miles Michael M Lai MD 301-656-8100
Cumberland Valley Retina Consultants PC - Hagerstown, Maryland 393.7 miles Allen Y Hu MD 310-467-4592
Cleveland Clinic - Cleveland, Ohio 544.9 miles Rishi Singh MD 216-445-9497
William Beaumont HospitalOphthalmology Research - Royal Oak, Michigan 616.2 miles George A Williams MD 248-551-2175
University of Michigan Kellogg Eye Center - Ann Arbor, Michigan 644.6 miles Grant Comer MD None None
Wake Forest Baptist Health Eye Center - Winston-Salem, North Carolina 659.2 miles Craig Greven MD 336-716-4091
Palmetto Retina Center LLC - Florence, South Carolina 736.8 miles W Lloyd Clark MD 803-931-0077
Retina Associates of Kentucky - Lexington, Kentucky 765.5 miles Thomas W Stone MD 859-263-3900
Western Carolina Retinal Associates - Asheville, North Carolina 774.5 miles William Z Bridges Jr MD 828-255-8008 None
Illinois Retina Associates - Oak Park, Illinois 856.7 miles Mathew W MacCumber MD PhD 773-871-8444
Southeast Retina Center PC - Augusta, Georgia 857.6 miles Dennis M Marcus MD 706-650-0061
Medical College of Wisconsin - Milwaukee, Wisconsin 862.1 miles David Weinberg MD 414-456-7840
Illinois Retina Associates SC - Joliet, Illinois 876.5 miles John S Pollack MD 815-744-7515
Georgina Retina PC - Marietta, Georgia 933.9 miles Robert Stoltz MD PhD 404-299-5209
Lifelong Vision Foundation - Chesterfield, Missouri 1,053.3 miles Nancy Holekamp MD 636-728-0111 None
Center for Retina and Macular Disease - Winter Haven, Florida 1,161.3 miles Michael Tolentino MD 863-297-5400
Retina Health Center - Ft. Myers, Florida 1,253.5 miles Alexander M Eaton MD 239-337-3337 None
National Ophthalmic Research Institute - Ft. Myers, Florida 1,255.3 miles Paul A Raskauskas MD 239-938-1284
Black Hills Regional Eye Institute - Rapid City, South Dakota 1,612.9 miles Prema Abraham MD 605-341-2000
Medical Center Ophthalmology Associates - San Antonio, Texas 1,769.8 miles Michael A Singer MD None
Colorado Retina Associates - Golden, Colorado 1,779.3 miles Brian Joondeph MD None
Valley Retina Institute PA - McAllen, Texas 1,902.3 miles Victor H Gonzalez MD 956-631-8875 None
Associated Retina Consultants Ltd - Phoenix, Arizona 2,294.3 miles Alan Gordon MD None None
Sierra Eye Associates - Reno, Nevada 2,519.5 miles Arshad Khanani MD 775-329-0286 None
Retina Northwest PC - Portland, Oregon 2,538.8 miles Michael S Lee MD None None
Jacobs Retina Center at UCSD - La Jolla, California 2,581.5 miles William R Freeman MD 858-822-3170 None
University of California Irvine The Gavin Herbert Eye Institute - Irvine, California 2,587.5 miles Baruch D Kuppermann MD PhD 949-824-6256
RetinaVitreous Associates Medical Group - Beverly Hills, California 2,601.9 miles David Boyer MD 310-854-6201 None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.