Flavors and E-cigarette Effects in Adolescent Smokers

Description

This study is to examine if inhaled doses of menthol that produce low and high cooling effects change the appeal of e-cigarettes containing low and high doses of nicotine in adolescent smokers. The hypothesis is that the combination of nicotine and menthol, when compared with menthol or nicotine alone, will result in greater increase in liking of an e-cigarette and greater reduction in nicotine withdrawal.

Study Start Date

October 2014

Estimated Completion Date

August 2018

Interventions

  • Other: High Dose Menthol
  • Drug: Nicotine
  • Other: Low Dose Menthol

Specialties

  • Psychiatry : Substance Abuse
  • Family Medicine: Substance Abuse
  • Nurse Practitioner: Substance Abuse

MeSH Terms

  • Low Dose Menthol
  • Tobacco Use Disorder

Study ID

Yale University -- 1307012312

Status

Unknown

Trial ID

NCT02179034

Study Type

Interventional

Trial Phase

Phase 1

Enrollment Quota

60

Sponsor

Yale University

Inclusion Criteria

  • Ages 16-19 years
  • Able to read and write
  • Cigarette smoker
  • Use of e-cigarettes in the past 30 days

Exclusion Criteria

  • Seeking smoking cessation treatment
  • Current/lifetime criteria for dependence on another psychoactive substance as diagnosed using the Diagnostic Interview Schedule for Children-IV (DISC-IV)
  • Daily use of alcohol or marijuana or use of any other drugs including cocaine, opiates, stimulants
  • Regular use of psychoactive drugs including anxiolytics, antidepressants and other psychostimulants
  • Current or past history of psychosis or other psychiatric diagnosis such as major depression
  • Any significant current medical condition

Gender

Both

Ages

16 Years to 19 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
CMHC - New Haven, Connecticut 17.3 miles Amanda Liss BA 203-974-7418 amanda.liss@yale.edu

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