Mindfulness Therapy on Disrupted Sleep in Bipolar Disorder


The investigators propose to investigate the efficacy of a brief (4-session) Body Scan (BS) meditation intervention for individuals with bipolar I disorder with insomnia (i.e. difficulties falling or staying asleep). The investigators will compare the Body Scan intervention with a 4-session brief supportive psychotherapy (SP) intervention. The investigators hypothesize that the Body Scan will improve objective sleep quantity and quality.

Study Start Date

February 2013

Estimated Completion Date

February 2016


  • Behavioral: Brief Supportive Psychotherapy (SP)
  • Behavioral: Body Scan (BS) Meditation Intervention


  • Internal Medicine: Neurology,Psychiatry
  • Psychiatry: Mood Disorders
  • Neurology: Neuropsych Sciences,Sleep

MeSH Terms

  • Bipolar Disorder
  • Bipolar Disorder
  • Disorders of Excessive Somnolence
  • Parasomnias
  • Sleep Disorders

Study ID

Massachusetts General Hospital -- 2012P002550



Trial ID


Study Type


Trial Phase


Enrollment Quota



Massachusetts General Hospital

Inclusion Criteria

  • Men and women age 18-65
  • DSM-IV diagnosis of bipolar I disorder
  • HAM-D-17 score < 12 (i.e. low or no depressive symptoms)
  • YMRS score < 8 (i.e. no or low manic symptoms)
  • Optimized, stable maintenance pharmacotherapy at maximum tolerated dosages in accordance with the revised Texas Implementation of Medication Algorithm
  • DSM-IV insomnia A and B criteria are met (i.e. difficulty initiating or maintaining sleep, for at least 1 month) as operationally defined by: 1. Insomnia Severity Index score of > 15 (moderate clinical insomnia) 2. M1 derived average actigraphic total sleep time < 6 hours, and < 40% average total sleep time in high frequency coupling, as measured with the M1 device over 5 days pre-randomization, corresponding to < 1SD below the mean of the M1 normative comparison sample of healthy control participants.

Exclusion Criteria

  • DSM-IV bipolar I disorder subtype rapid cycling
  • DSM-IV manic or mixed episode in the past 2 months
  • DSM-IV major depressive episode in the past 2 months
  • Psychotropic medication not in accordance with the revised Texas Implementation of Medication Algorithm
  • Pregnancy
  • Medical illness or non-psychiatric medical treatment that is the likely cause of the sleep disturbance or interferes with study participation
  • Neurologic disorder, previous ECT, or history of head trauma (i.e. known structural brain lesion)
  • Current or past history of selected DSM-IV Axis I disorders other than bipolar disorder including: organic mental disorder, substance abuse within the past 12 months and/or history of substance abuse for > 1 year
  • past or current substance dependence (including alcohol), schizophrenia, delusional disorder, psychotic disorders not otherwise specified
  • Axis I disorder that needs to be the primary focus of treatment (e.g. current DSM-IV anxiety disorder that disrupts sleep)
  • Sleep apnea, restless leg syndrome, or narcolepsy
  • Concurrent psychotherapy to BS or SP.




18 Years to 65 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles None None None

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