Estimating Apnea Phenotypes From Polysomnography: Oxygen


This study seeks to employ advanced methods to estimate the individual factors contributing to sleep apnea from standard recordings made during routine clinical sleep studies. This study focuses on breathing control or "loop gain" as one of the factors contributing to sleep apnea. Increased levels of oxygen in the air is known to make breathing more stable by lowering "loop gain". Here, the goal of this study is to use a new method capable of detecting a reduction in loop gain with oxygen. The investigators also aim to test whether a high loop gain measured at baseline/placebo predicts a greater improvement in sleep apnea with oxygen therapy.

Study Start Date

November 2012

Estimated Completion Date

July 2016


  • Other: Sham
  • Drug: Inspired oxygen (40%)


  • Internal Medicine: Clinical Pharmacology,Pulmonology
  • Pulmonology: Apnea/Sleep Disorders,Clinical Pharmacology
  • Family Medicine: Clinical Pharmacology,General Medicine
  • Pharmacy: Drug Trials
  • Physician Assistant: Clinical Pharmacology,Family Medicine,General Medicine

MeSH Terms

  • Sleep Apnea Syndromes
  • Sleep Apnea, Central
  • Sleep Apnea, Obstructive

Study ID

Brigham and Women's Hospital -- 2005P001296-O2PSG



Trial ID


Study Type


Trial Phase


Enrollment Quota



Brigham and Women's Hospital

Inclusion Criteria

  • Apnea/hypopnea index >20 events per hour
  • Age 20-79 years

Exclusion Criteria

  • COPD with desaturation (resting SpO2<96%)
  • Use of respiratory stimulants or depressants
  • Pregnancy




20 Years to 79 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Scott SANDS PhD None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.