Adaptive Interventions for Minimally Verbal Children With ASD in the Community


Adaptive Interventions for Minimally Verbal Children with ASD in the Community, seeks support to construct an adaptive intervention that utilizes two efficacious interventions (JASP-EMT and CORE- DTT) that have shown promise for optimizing the number of unique socially communicative and spontaneously spoken words in minimally verbal children with ASD. The study utilizes a novel sequential multiple assignment-randomized trial to evaluate and construct an optimal adaptive intervention. A total of 192 minimally verbal school aged children with an Autism Spectrum Disorder (aged 5 to 8 years of age) will participate across four sites, UCLA, University of Rochester, Vanderbilt University and Weill Cornell Medical Center with methodological and statistical support from University of Michigan.

Study Start Date

January 2013

Estimated Completion Date

January 2018


  • Behavioral: JASP-EMT
  • Behavioral: DTT


  • Cardiology: Congenital
  • Pediatrics: Pediatric Cardiology

MeSH Terms

  • Autistic Disorder
  • Behavioral: DTT

Study ID

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) -- RO1HD073975



Trial ID


Study Type


Trial Phase


Enrollment Quota



Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Inclusion Criteria

  • Clinical diagnosis of autism
  • At least 4.5 years old, and not older than 8.0 years
  • Displays less than 20 spontaneous, unique, and socially communicative words during screening assessments
  • At least 18 months developmental age
  • Currently in school

Exclusion Criteria

  • Diagnosis of syndrome or degenerative disorder
  • Poorly controlled seizures




54 Months to 8 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (4)

Study Location Distance Name Phone Email
Weill Cornell Medical College - White Plains, New York 29.7 miles Catherine Lord PhD None
University of Rochester - Rochester, New York 260.4 miles Tristram Smith PhD None
Vanderbilt University - Nashville, Tennessee 810.5 miles Ann Kaiser PhD None
University of California Los Angeles - Los Angeles, California 2,498.9 miles Connie Kasari PhD 310-825-8342 provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.