Functional Applications of Hyperpolarized 129Xe MRI


The overall objectives of our study are to determine the capabilities of hyperpolarized 129Xe MRI to measure lung function and its potential to sensitively detect pulmonary disease and its progression in COPD. We hypothesize that measurement of alveolar surface area, septal thickness, and capillary transit time measured with hyperpolarized 129Xe will correlate better with quality of life measures in COPD subjects than traditional diagnostic measures such as spirometry and Computed Tomography.

Study Start Date

January 2013

Estimated Completion Date

November 2016


  • Drug: Hyperpolarized 129Xe gas


  • Internal Medicine: Pulmonology
  • Pulmonology: COPD,Diagnostic/Lung Function
  • Radiology: MRI

MeSH Terms

  • Chronic Obstructive Pulmonary Disease
  • Hyperpolarized
  • Lung Diseases
  • Obstructive

Study ID

Brigham and Women's Hospital -- Hyperpolarized xenon



Trial ID


Study Type


Trial Phase

Phase 1/Phase 2

Enrollment Quota



Brigham and Women's Hospital

Inclusion Criteria

  • Age 18-80 For Healthy nonsmoker subjects:
  • No current physician diagnosed medical disease requiring active medication
  • No smoking history, defined as less than 100 cigarettes smoked in a lifetime
  • Normal spirometry: FEV1/FVC ? 0.70, FEV1 ? 80% predicted For Subjects who have participated in the COPDGene Study
  • Post-bronchodilator spirometry: FEV1 > 40% predicted

Exclusion Criteria

  • MR contraindications: e.g., electrical implants such as cardiac pacemakers, ferromagnetic implants such as prostheses, claustrophobia
  • Pregnancy or suspected pregnancy
  • Use of continuous oxygen
  • Use of antibiotics and/or systemic corticosteroids (new prescription or increased dose) for an exacerbation of lung disease or any lung infection in the past four weeks
  • Uncontrolled cancer, as defined as ongoing radiation therapy, ongoing chemotherapy
  • A heart attack in the past three months




18 Years to 80 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Brigham Womens Hospital - Boston, Massachusetts 2.6 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.