Understanding How Cognitive Remediation Works

Description

This study is aimed at evaluating whether the computer-based cognitive exercises in the Thinking Skills for Work (TSW) program are critical to improving work and cognitive outcomes in consumers with serious mental illness and cognitive impairment enrolled in supported employment (SE), or whether a streamlined version of TSW without this component (the Cognitive Skills for Work (CSW) program) is equally effective for some or all consumers. An RCT will be conducted at two sites (Mental Health Center of Greater Manchester in New Hampshire and Thresholds Inc. in Illinois) with 244 consumers randomly assigned to one of two groups (122 each, with approximately 122 participants having schizophrenia or schizoaffective disorder and 122 of the participants having other diagnoses): 1) TSW, or 2) CSW. The TSW and CSW programs will be delivered by the same Cognitive Specialists, who will work as members of the SE team to integrate cognitive and vocational services. All participants will continue to receive SE services. Participants will be assessed at baseline, post-treatment (4-6 months after completion of the active teaching components of TSW or CSW), and 1- and 2-year post-baseline to evaluate cognitive functioning, symptoms, and quality of life. All work outcomes will be tracked weekly.

Study Start Date

September 2012

Estimated Completion Date

January 2017

Interventions

  • Behavioral: The Thinking Skills for Work Program
  • Behavioral: The Cognitive Skills for Work Program

Specialties

  • Psychiatry: Mood Disorders,Psychotherapy/analysis,Schizophrenia/Psychosis

MeSH Terms

  • Bipolar Disorder
  • Depressive Disorder, Major
  • Mental Disorders
  • Psychotic Disorders
  • Schizophrenia

Study ID

Boston University -- 2837E

Status

Unknown

Trial ID

NCT01683539

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

244

Sponsor

Boston University

Inclusion Criteria

  • Chronic mental disorder
  • Minimum age 18.
  • Unemployed
  • Wants employment
  • Fluent in English.
  • Cognitively impaired, as defined by 1.0 SD below normative scores in memory or executive functioning
  • Willing and legally able to provide informed consent to participate in study. Subjects with court appointed legal guardians will be included.

Exclusion Criteria

    -History of neurological conditions that impair cognition

Gender

Both

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
The Mental Health Center of Greater Manchester - Manchester, New Hampshire 45.1 miles None None None
Thresholds - Chicago, Illinois 849.4 miles None None None

ClinicalTrialsLocator.com provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from ClinicalTrials.gov. This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.