Understanding How Cognitive Remediation Works
This study is aimed at evaluating whether the computer-based cognitive exercises in the Thinking Skills for Work (TSW) program are critical to improving work and cognitive outcomes in consumers with serious mental illness and cognitive impairment enrolled in supported employment (SE), or whether a streamlined version of TSW without this component (the Cognitive Skills for Work (CSW) program) is equally effective for some or all consumers. An RCT will be conducted at two sites (Mental Health Center of Greater Manchester in New Hampshire and Thresholds Inc. in Illinois) with 244 consumers randomly assigned to one of two groups (122 each, with approximately 122 participants having schizophrenia or schizoaffective disorder and 122 of the participants having other diagnoses): 1) TSW, or 2) CSW. The TSW and CSW programs will be delivered by the same Cognitive Specialists, who will work as members of the SE team to integrate cognitive and vocational services. All participants will continue to receive SE services. Participants will be assessed at baseline, post-treatment (4-6 months after completion of the active teaching components of TSW or CSW), and 1- and 2-year post-baseline to evaluate cognitive functioning, symptoms, and quality of life. All work outcomes will be tracked weekly.
Study Start Date
Estimated Completion Date
- Behavioral: The Thinking Skills for Work Program
- Behavioral: The Cognitive Skills for Work Program
- Psychiatry: Mood Disorders,Psychotherapy/analysis,Schizophrenia/Psychosis
- Bipolar Disorder
- Depressive Disorder, Major
- Mental Disorders
- Psychotic Disorders
Boston University -- 2837E
- Chronic mental disorder
- Minimum age 18.
- Wants employment
- Fluent in English.
- Cognitively impaired, as defined by 1.0 SD below normative scores in memory or executive functioning
- Willing and legally able to provide informed consent to participate in study. Subjects with court appointed legal guardians will be included.
-History of neurological conditions that impair cognition
18 Years and older
Accepts Healthy Volunteers
Study Locations and Contact Information (2)
|The Mental Health Center of Greater Manchester - Manchester, New Hampshire||45.1 miles||None||None||None|
|Thresholds - Chicago, Illinois||849.4 miles||None||None||None|