Effects of Topiramate on Adolescent Alcohol Use: Efficacy and Mechanisms

Description

This study will help to determine whether the medication, topiramate, reduces alcohol use among adolescents with alcohol dependence. It will also help answer the question, "How does topiramate reduce drinking in teenagers?" Understanding how topiramate may reduce drinking in adolescents would allow for a more targeted pharmacotherapeutic approach to treatment and help to identify additional medications that may hold promise for improving treatment outcomes for youth.

Study Start Date

July 2012

Estimated Completion Date

August 2016

Interventions

  • Drug: Placebo
  • Drug: Topiramate

Specialties

  • Pediatrics: Adol/Youth Medicine,Child/Adolescent Psych,Clinical Pharmacology
  • Psychiatry: Child/Adolescent Psych,Neuro/Psych Pharmacol,Substance Abuse
  • Family Medicine: Adol/Youth Medicine,Clinical Pharmacology,Substance Abuse
  • Pharmacy: Drug Trials,Neuro/Psych pharmacology

MeSH Terms

  • Alcohol Drinking
  • Alcoholism

Study ID

Brown University -- R01 AA007850-21

Status

Unknown

Trial ID

NCT01641445

Study Type

Interventional

Trial Phase

Phase 1/Phase 2

Enrollment Quota

160

Sponsor

Brown University

Inclusion Criteria

  • 14-20 years old (inclusive)
  • Non-treatment seeking for alcohol abuse or dependence
  • Interest in reducing alcohol use
  • Able to read simple English

Exclusion Criteria

  • Alcohol or substance abuse treatment in the past 30 days
  • Clinically significant medical abnormalities
  • History of renal impairment, renal stones, or unstable hypertension
  • Body mass index lower than 18
  • Pregnant, nursing, or refusal to use reliable birth control, if female
  • Non-stabilized psychotropic medication
  • Medications that may effect alcohol use or a carbonic anhydrase inhibitor
  • Suicidal or psychotic
  • Clinically significant alcohol withdrawal symptoms
  • Impaired cognitive functioning
  • Living with an active study participant

Gender

Both

Ages

14 Years to 20 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
Brown University Center for Alcohol and Addiction Studies - Providence, Rhode Island 40.5 miles None None None
Brown University Center for Alcohol and Addiction Studies - Providence, Rhode Island 40.5 miles Robert Jr 401-863-6658 Robert_Miranda_Jr@Brown.EDU

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