Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors

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Description

The primary purpose of the study is to increase our knowledge of receptor function in the brains of people who are heavy drinkers and taking naltrexone (NTX), a medication that has been approved for the treatment of alcohol dependence. Receptors are special molecules in the brain to which other molecules (neurotransmitters) attach during the normal every-day workings of the brain. Drugs can bind to those receptor molecules as well. Recent evidence suggests that kappa opioid receptors (KOR's) may play an important role in alcohol drinking behavior. This study will try to determine if naltrexone's ability to attach to these receptors is related to its effectiveness. We will use PET (positron emission tomography) for this study. PET is a type of imaging device found in nuclear medicine. It is used for tracking the presence of injected radioactive materials in the body.

Study Start Date

February 2011

Estimated Completion Date

June 2018

Interventions

Drug: Naltrexone

Specialties

Psychiatry: Neuropsych Sciences,Substance Abuse
Neurology: Neuropsych Sciences
Family Medicine: Substance Abuse
Radiology: CT/SPECT/PET

MeSH Terms

Alcohol Drinking
Drinking Behavior
Naltrexone

Study ID

Yale University -- 1011007710

Status

Unknown

Trial ID

NCT01625611

Study Type

Interventional

Trial Phase

Phase 1

Enrollment Quota

Sponsor

Yale University

Inclusion Criteria

Ages 21-50
Able to read English at 6th grade level or higher and to complete study evaluations
Regular alcohol drinker

Exclusion Criteria

Individuals who are seeking alcohol treatment
Medical conditions that would contraindicate the use of study medication
Regular use of other substances

Gender

Both

Ages

21 Years to 50 Years

Accepts Healthy Volunteers

Study Locations and Contact Information (2)

Study Location	Distance	Name	Phone	Email
Sac Cmhc - New Haven, Connecticut	17.3 miles	None	None	None
Sac Cmhc - New Haven, Connecticut	17.3 miles	Nicholas Franco BA	203-974-7679	nicholas.franco@yale.edu

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