"Dusting" Versus "Basketing" - Treatment Of Intrarenal Stones

Description

The purpose of this study is to evaluate outcomes of an established procedure for treatment of kidney stones that are present within the inner aspect of the kidney. This procedure is called flexible ureteroscopy, which involves placing a small camera through the urethra while anesthetized (asleep), up the ureter (the tube connecting kidney and bladder) and into the kidney to the kidney stone. Then, the stone is broken into tiny fragments using a small laser called a Holmium laser. While this treatment is a well-established option for treatment of these stones, there are several different techniques used to help eliminate them from the kidney. Some urologists treat the stone by a method called "active" extraction whereby the ureteroscope is passed back and forth into the kidney to remove all visible stone fragments. Others use a method called "dusting" whereby the stones are broken into tiny fragments or "dust" with the intention that achieving such a small stone size will allow the stones to pass spontaneously. There has not been a systematic and rigorous comparison of these techniques in terms of treatment outcomes. By collecting information on the success of treatment, the investigators hope to provide benchmark data for future studies of kidney stone treatment and improve the care of all patients who need surgery for their kidney stones. The investigators hypothesize that the stone free rate for renal stone(s) 5-15 mm is around 90% and that the stone clearance rate with be 20% higher in those patients that undergo complete stone fragment extraction versus those that undergo stone dusting (residual fragments < 2mm).

Study Start Date

April 2013

Estimated Completion Date

December 2016

Interventions

No interventions cited

Specialties

  • Urology: Kidney,Stone Disease
  • Nephrology: Stone Disease

MeSH Terms

  • Kidney Calculi
  • Lithotripsy, Laser
  • Ureteroscopy

Study ID

Mayo Clinic -- 12-002553

Status

Unknown

Trial ID

NCT01619735

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

150

Sponsor

Mayo Clinic

Inclusion Criteria

  • Radiopaque renal stones above the level of the ureteropelvic junction
  • Kidney stones must range from 5 to 15 mm in size or in the case of multiple stones the conglomerate diameter (additive maximal diameter of all stones on axial imaging of computed tomography) of 5-15 mm is required for inclusion
  • Patient must be a suitable operative candidate for flexible ureteroscopy

Exclusion Criteria

  • Will include concomitant stones in the ureter
  • Patients who have had prior ipsilateral upper urinary tract reconstructive procedures or history of ipsilateral ureteral stricture
  • Patients who have undergone prior radiotherapy to the abdomen or pelvis and those who have a neurogenic bladder or spinal cord injury
  • Pregnant subjects

Gender

Both

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (17)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles None None None
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles Brian Eisner MD 617-726-2000 beisner@partners.org
Dartmouth University - Hanover, New Hampshire 110.4 miles None None None
Dartmouth University - Hanover, New Hampshire 110.4 miles Vernon M Pais MD None Vernon.M.Pais.Ju@hitchcock.org
Bellevue Hospital - New York, New York 186.5 miles None None None
James Buchanan Brady Urological Institute - Baltimore, Maryland 356.0 miles None None None
James Buchanan Brady Urological Institute - Baltimore, Maryland 356.0 miles Brian Matlaga MD MPH 410-502-7710 bmatlagq@jhmi.edu
Cleveland Clinic - Cleveland, Ohio 544.9 miles None None None
Cleveland Clinic - Cleveland, Ohio 544.9 miles Carl Sarkissian None sarkisc@ccf.org
Duke University - Durham, North Carolina 609.0 miles Michael Lipkin MD 919-681-5506 michael.lipkin@duke.edu
Duke University - Durham, North Carolina 609.0 miles None None None
Ohio State University - Columbus, Ohio 641.8 miles None None None
Vanderbilt University School of Medicine - Nashville, Tennessee 944.2 miles Nicole Miller MD 615-322-5000 Nicole.miller@Vanderbilt.Edu
Vanderbilt University School of Medicine - Nashville, Tennessee 944.2 miles None None None
Mayo Clinic - Scottsdale, Arizona 2,280.6 miles None None None
UCSD - San Diego, California 2,582.6 miles Roger Sur MD 619-543-2628 None
UCSD - San Diego, California 2,582.6 miles None None None

ClinicalTrialsLocator.com provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from ClinicalTrials.gov. This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.