ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators

Description

The primary aim of this study is to test the effects of excitation of ventral striatal circuitry via DBS (e.g. DBS-on versus DBS-off) on reward motivation. The investigators predict that stimulation will increase subject willingness to expend effort for rewards and facilitate motivation for reward learning. The investigators further predict that individual differences in the effects of DBS on reward motivation as will be associated with effects of DBS treatment on anhedonic symptoms.

Study Start Date

June 2012

Estimated Completion Date

December 2017

Interventions

  • Device: Medtronic IPG Neurostimulator

Specialties

  • Psychiatry: Anxiety
  • Neurology: Neuroradiology
  • Radiology: Neuroradiology

MeSH Terms

  • Depressive Disorder
  • Major Depressive Disorder
  • Medtronic IPG Neurostimulator

Study ID

Massachusetts General Hospital -- 2011P002821

Status

Unknown

Trial ID

NCT01590862

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

60

Sponsor

Massachusetts General Hospital

Inclusion Criteria

  • Deep brain stimulator implantation performed at least three months prior to study

Exclusion Criteria

  • Subjects unable to visualize stimulus objects with correction
  • Dementia or other known cognitive deficit

Gender

Both

Ages

18 Years to 70 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles Darin D Dougherty MD None ddougherty@partners.org
Massachusetts General Hospital - Charlestown, Massachusetts 2.9 miles Anna L Gilmour BA 617-726-9281 agilmour@partners.org

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