Naltrexone and Memantine Effects on Alcohol Drinking Behaviors


The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors. Participants will be randomized to receive a combination of these medications over a one week period and then participate in a laboratory session. During this session, participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. These medications are hypothesized to reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period.

Study Start Date

January 2012

Estimated Completion Date

January 2017


  • Drug: Naltrexone and Placebo
  • Drug: Naltrexone and memantine


  • Psychiatry: Substance Abuse
  • Family Medicine: Substance Abuse

MeSH Terms

  • Alcohol Drinking
  • Naltrexone

Study ID

Yale University -- 1005006779



Trial ID


Study Type


Trial Phase

Phase 2

Enrollment Quota



Yale University

Inclusion Criteria

  • Ages 21-50
  • Able to read English at 6th grade level or higher and to complete study evaluations
  • Regular alcohol drinker

Exclusion Criteria

  • Individuals who are seeking alcohol treatment
  • Medical conditions that would contraindicate the use of study medication
  • Regular use of other substances




21 Years to 50 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Sac Cmhc - New Haven, Connecticut 17.3 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.