Clinical and Biological Predictors of Chemotherapy Toxicity in Older Adults

Description

The goal of this study is to develop a "bedside to bench" model of clinical and biological predictors for toxicity to adjuvant and neoadjuvant chemotherapy in older adults with breast cancer. The investigators will develop a predictive model using clinical and biological predictors of toxicity to adjuvant and neoadjuvant chemotherapy in older adults with breast cancer. The investigators will also determine the association between clinical and biological factors and reduced relative dose intensity of the prescribed chemotherapy regimen. In addition, the investigators will explore specific chemotherapy toxicities associated with reduced relative dose intensity of a prescribed regimen.

Study Start Date

September 2011

Estimated Completion Date

September 2016

Interventions

No interventions cited

Specialties

  • Obstetrics & Gynecology: Breast
  • Family Medicine: Geriatrics
  • Oncology: Breast

MeSH Terms

  • Breast Neoplasms

Study ID

City of Hope Medical Center -- 11127

Status

Unknown

Trial ID

NCT01472094

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

700

Sponsor

City of Hope Medical Center

Inclusion Criteria

  • Patients with stages I-III breast cancer receiving adjuvant or neoadjuvant chemotherapy
  • Able to understand English
  • Able to provide informed consent
  • Patients age ?65 and of any performance status are eligible

Exclusion Criteria

  • Patients with metastatic disease

Gender

Both

Ages

65 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (27)

Study Location Distance Name Phone Email
DanaFarber Cancer Institute - Boston, Massachusetts 2.4 miles None None None
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles None None None
Rhode Island Hospital - Providence, Rhode Island 41.0 miles Mary Anne Fenton MD 401-444-5394 MFenton@Lifespan.org
Rhode Island Hospital - Providence, Rhode Island 41.0 miles None None None
Yale University - New Haven, Connecticut 119.2 miles None None None
HofstraNorthLIJ Cancer Institute - New Hyde Park, New York 174.6 miles Myra Barginear MD 516-734-8745 mbarginear@NSHS.edu
HofstraNorthLIJ Cancer Institute - New Hyde Park, New York 174.6 miles None None None
Memorial SloanKettering Cancer Center - New York, New York 187.1 miles None None None
Fox Chase Cancer Center - Philadelphia, Pennsylvania 261.7 miles None None None
Fox Chase Cancer Center - Philadelphia, Pennsylvania 261.7 miles Efrat Dotan MD 215-728-3545 Efrat.dotan@fccc.edu
Thomas Jefferson University - Philadelphia,, Pennsylvania 269.5 miles None None None
Thomas Jefferson University - Philadelphia,, Pennsylvania 269.5 miles Andrew Chapman DO 215-955-8979 Andrew.chapman@jefferson.edu
University of Rochester Medical Center - Rochester, New York 335.8 miles Supriya Mohile MD 585-273-4150 Supriya_Mohile@URMC.Rochester.edu
University of Rochester Medical Center - Rochester, New York 335.8 miles None None None
Roswell Park Cancer Institute - Buffalo, New York 397.2 miles Tracey OConnor MD 716-845-4074 Tracey.O'Connor@roswellpark.org
Roswell Park Cancer Institute - Buffalo, New York 397.2 miles None None None
University of Virginia Health System - Charlottesville, Virginia 493.5 miles Erika Ramsdale MD 434-297-7782 eer2x@virginia.edu
University of Virginia Health System - Charlottesville, Virginia 493.5 miles None None None
Case Western Reserve University - Cleveland, Ohio 544.0 miles None None None
University of North Carolina - Chapel Hill, North Carolina 615.9 miles None None None
Wake Forest University - Winston-Salem, North Carolina 654.9 miles Heidi Klepin MD 336-713-6920 hklepin@wakehealth.edu
Wake Forest University - Winston-Salem, North Carolina 654.9 miles None None None
University of Chicago - Chicago, Illinois 848.0 miles None None None
Washington University St Louis - St. Louis, Missouri 1,039.5 miles Tanya Wildes MD 314-747-8468 None
Washington University St Louis - St. Louis, Missouri 1,039.5 miles None None None
City of Hope Medical Center - Duarte, California 2,578.2 miles None None None
City of Hope Medical Center - Duarte, California 2,578.2 miles Arti Hurria MD 626-256-4673 ahurria@coh.org

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