Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Description

This randomized phase III trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed high-risk acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) and giving the drugs in different doses and in different combinations may kill more cancer cells.

Study Start Date

February 2012

Estimated Completion Date

August 2021

Interventions

  • Drug: clofarabine
  • Drug: doxorubicin hydrochloride
  • Drug: dexamethasone
  • Drug: Prednisone
  • Drug: leucovorin calcium
  • Drug: Mercaptopurine
  • Drug: Methotrexate
  • Drug: pegaspargase
  • Drug: vincristine sulfate
  • Drug: Etoposide
  • Drug: Leucovorin Calcium
  • Drug: Thioguanine
  • Drug: methotrexate
  • Drug: cytarabine
  • Drug: mercaptopurine tablet
  • Drug: Clofarabine
  • Drug: Cyclophosphamide
  • Drug: Cytarabine
  • Other: Laboratory Biomarker Analysis
  • Drug: etoposide
  • Drug: hydrocortisone sodium succinate
  • Drug: thioguanine
  • Drug: Doxorubicin Hydrochloride
  • Drug: Hydrocortisone Sodium Succinate
  • Drug: Pegaspargase
  • Drug: Vincristine Sulfate
  • Radiation: selective external radiation therapy
  • Radiation: Radiation Therapy
  • Drug: cyclophosphamide
  • Drug: mercaptopurine
  • Drug: prednisone
  • Drug: Dexamethasone

Specialties

  • Oncology: Leukemia/Lymphoma,Pharmacology/Therapy
  • Pharmacy: Chemotherapy/Oncology,Drug Interactions,Drug Trials

MeSH Terms

  • Leukemia, Lymphoid

Study ID

National Cancer Institute (NCI) -- CDR0000706370

Status

Recruiting

Trial ID

NCT01406756

Study Type

Interventional

Trial Phase

Phase 3

Enrollment Quota

4895

Sponsor

National Cancer Institute (NCI)

DISEASE CHARACTERISTICS:
  • Patients must have newly diagnosed B-precursor acute lymphoblastic leukemia (ALL)
  • patients with Down syndrome (DS) are also eligible
  • Patients must have one of the following:
  • NCI high-risk ALL or NCI standard-risk ALL with central nervous system (CNS), testicular leukemia, and/or steroid pre-treatment, and be enrolled in COG AALL08B1
  • patients that begin therapy on this study (AALL1131) prior to enrollment on COG AALL08B1 are ineligible
  • NCI standard-risk ALL, be enrolled in COG AALL08B1 or COG AALL0932 and completed AALL0932 induction treatment and been classified as high-risk or very high-risk
  • Patients with BCR-ABL1 (Philadelphia chromosome positive) are not eligible for post-induction therapy on this study
  • non-DS patients may be eligible to enroll in COG AALL0622 or successor COG Ph+ ALL trial by day 15 induction
  • DS HR-ALL patients with induction failure or BCR-ABL1 are not eligible for post-induction
  • No VHR-ALL patients with significant hepatic dysfunction at the time of post-induction randomization defined as:
  • Direct bilirubin > 1.5 times upper limit of normal (ULN) for age
  • SGPT (ALT) >= 3 times ULN for age
  • Lipase > 2.0 times ULN for age
  • Patients cannot have secondary ALL that developed after treatment of a prior malignancy with cytotoxic chemotherapy PATIENT CHARACTERISTICS:
  • White blood cell count (WBC) criteria:
  • Age 1-9.99 years: WBC >= 50 000/ÎŒL
  • Age 10-30.99 years: Any WBC
  • Age 1-30.99 years: Any WBC with:
  • Testicular leukemia
  • CNS leukemia (CNS3)
  • Steroid pretreatment
  • No very high-risk (VHR) acute lymphoblastic leukemia (ALL) patients with hepatitis B or C infection or history of cirrhosis at the time of post-induction randomization
  • Negative pregnancy test
  • Patients of childbearing potential must agree to use an effective birth control method
  • Female patients who are lactating must agree to stop breast-feeding PRIOR CONCURRENT THERAPY:
  • See Disease Characteristics
  • Patients must not have received any prior cytotoxic chemotherapy for the current diagnosis of acute lymphoblastic leukemia (ALL) or any cancer diagnosed previously, with the exception of steroids and intrathecal cytarabine for the current diagnosis of ALL
  • Patients receiving prior steroid therapy may be eligible
  • No concurrent intensity-modulated radiotherapy
  • Gender

    Both

    Ages

    1 Year to 30 Years

    Accepts Healthy Volunteers

    No

    Study Locations and Contact Information (306)

    Study Location Distance Name Phone Email
    Yale University - New Haven, Connecticut 18.1 miles None None None
    Stony Brook University Medical Center - Stony Brook, New York 22.8 miles None None None
    Stony Brook University Medical Center - Stony Brook, New York 22.8 miles Robert I Parker 800-862-2215 None
    New York Medical College - Valhalla, New York 28.9 miles Jessica C Hochberg 914-594-3794 None
    New York Medical College - Valhalla, New York 28.9 miles None None None
    Winthrop University Hospital - Mineola, New York 38.5 miles None None None
    Winthrop University Hospital - Mineola, New York 38.5 miles Mark E Weinblatt 866-946-8476 None
    The Steven and Alexandra Cohen Childrens Medical Center of New York - New Hyde Park, New York 39.6 miles None None None
    The Steven and Alexandra Cohen Childrens Medical Center of New York - New Hyde Park, New York 39.6 miles Arlene S Redner 718-470-3470 None
    Connecticut Childrens Medical Center - Hartford, Connecticut 46.8 miles None None None
    Mount Sinai Medical Center - New York, New York 46.8 miles Birte Wistinghausen 212-824-7320 jenny.figueroa@mssm.edu
    Mount Sinai Medical Center - New York, New York 46.8 miles None None None
    Hackensack University Medical Center - Hackensack, New Jersey 47.6 miles None None None
    Laura and Isaac Perlmutter Cancer Center at NYU Langone - New York, New York 50.2 miles None None None
    Weill Medical College of Cornell University - New York, New York 50.7 miles None None None
    Saint Josephs Regional Medical Center - Paterson, New Jersey 52.3 miles None None None
    Saint Josephs Regional Medical Center - Paterson, New Jersey 52.3 miles Mary A Bonilla 973-754-2909 None
    Newark Beth Israel Medical Center - Newark, New Jersey 61.3 miles Peri Kamalakar 973-926-7230 None
    Newark Beth Israel Medical Center - Newark, New Jersey 61.3 miles None None None
    Saint Barnabas Medical Center - Livingston, New Jersey 63.4 miles None None None
    Saint Barnabas Medical Center - Livingston, New Jersey 63.4 miles None None None
    Overlook Hospital - Summit, New Jersey 67.9 miles None None None
    Overlook Hospital - Summit, New Jersey 67.9 miles Steven L Halpern 973-971-5900 None
    Baystate Medical Center - Springfield, Massachusetts 70.9 miles None None None
    Morristown Medical Center - Morristown, New Jersey 71.1 miles None None None
    Rutgers Cancer Institute of New JerseyRobert Wood Johnson University Hospital - New Brunswick, New Jersey 79.6 miles None None None
    Saint Peters University Hospital - New Brunswick, New Jersey 80.6 miles None None None
    Albany Medical Center - Albany, New York 103.6 miles None None None
    Rhode Island Hospital - Providence, Rhode Island 104.1 miles None None None
    Rhode Island Hospital - Providence, Rhode Island 104.1 miles Jennifer J Greene Welch 401-444-1488 None
    University of Massachusetts Medical School - Worcester, Massachusetts 106.5 miles None None None
    University of Massachusetts Medical School - Worcester, Massachusetts 106.5 miles Christopher P Keuker 508-856-3216 cancer.research@umassmed.edu
    Lehigh Valley Hospital Muhlenberg - Bethlehem, Pennsylvania 115.9 miles None None None
    Saint Christophers Hospital for Children - Philadelphia, Pennsylvania 129.6 miles Akash Nahar 215-427-8991 None
    Saint Christophers Hospital for Children - Philadelphia, Pennsylvania 129.6 miles None None None
    Childrens Hospital of Philadelphia - Philadelphia, Pennsylvania 134.5 miles None None None
    Floating Hospital for Children at Tufts Medical Center - Boston, Massachusetts 137.7 miles None None None
    Massachusetts General Hospital Cancer Center - Boston, Massachusetts 137.9 miles Howard Weinstein 212-639-7202 None
    Massachusetts General Hospital Cancer Center - Boston, Massachusetts 137.9 miles None None None
    Alfred I duPont Hospital for Children - Wilmington, Delaware 155.5 miles None None None
    Alfred I duPont Hospital for Children - Wilmington, Delaware 155.5 miles Jeffrey H Schwartz 904-697-3529 None
    Dartmouth Hitchcock Medical Center - Lebanon, New Hampshire 175.0 miles None None None
    Geisinger Medical Center - Danville, Pennsylvania 176.4 miles None None None
    Geisinger Medical Center - Danville, Pennsylvania 176.4 miles Jagadeesh Ramdas 570-271-5251 None
    Penn State Hershey Childrens Hospital - Hershey, Pennsylvania 188.9 miles Lisa M McGregor 717-531-6012 None
    Penn State Hershey Childrens Hospital - Hershey, Pennsylvania 188.9 miles None None None
    State University of New York Upstate Medical University - Syracuse, New York 194.1 miles None None None
    State University of New York Upstate Medical University - Syracuse, New York 194.1 miles Karol H Kerr 315-464-5476 None
    Johns Hopkins UniversitySidney Kimmel Cancer Center - Baltimore, Maryland 219.6 miles None None None
    Maine Childrens Cancer Program - Scarborough, Maine 220.4 miles None None None
    University of MarylandGreenebaum Cancer Center - Baltimore, Maryland 222.5 miles None None None
    Sinai Hospital of Baltimore - Baltimore, Maryland 223.1 miles None None None
    University of Vermont College of Medicine - Burlington, Vermont 225.8 miles None None None
    University of Vermont College of Medicine - Burlington, Vermont 225.8 miles Alan C Homans 802-656-4101 None
    Childrens National Medical Center - Washington, District of Columbia 255.3 miles Jeffrey S Dome 202-884-2549 None
    Childrens National Medical Center - Washington, District of Columbia 255.3 miles None None None
    MedStar Georgetown University Hospital - Washington, District of Columbia 258.0 miles None None None
    University of Rochester - Rochester, New York 260.4 miles Jeffrey R Andolina 585-275-5830 None
    University of Rochester - Rochester, New York 260.4 miles None None None
    Inova Fairfax Hospital - Falls Church, Virginia 265.0 miles Marshall A Schorin 703-208-6650 None
    Inova Fairfax Hospital - Falls Church, Virginia 265.0 miles None None None
    Roswell Park Cancer Institute - Buffalo, New York 310.8 miles None None None
    Roswell Park Cancer Institute - Buffalo, New York 310.8 miles Barbara J Bambach 877-275-7724 None
    Eastern Maine Medical Center - Bangor, Maine 336.7 miles Sam W Lew 207-973-4274 None
    Eastern Maine Medical Center - Bangor, Maine 336.7 miles None None None
    Virginia Commonwealth UniversityMassey Cancer Center - Richmond, Virginia 338.8 miles None None None
    Childrens HospitalKings Daughters - Norfolk, Virginia 343.3 miles None None None
    Childrens HospitalKings Daughters - Norfolk, Virginia 343.3 miles Eric J Lowe 757-668-7243 None
    Childrens Hospital of Pittsburgh of UPMC - Pittsburgh, Pennsylvania 354.7 miles None None None
    University of Virginia Cancer Center - Charlottesville, Virginia 357.0 miles None None None
    West Virginia University Healthcare - Morgantown, West Virginia 371.3 miles None None None
    Childrens Hospital Medical Center of Akron - Akron, Ohio 431.1 miles None None None
    Rainbow Babies and Childrens Hospital - Cleveland, Ohio 434.6 miles None None None
    Cleveland Clinic Foundation - Cleveland, Ohio 435.4 miles Aron Flagg 866-223-8100 None
    Cleveland Clinic Foundation - Cleveland, Ohio 435.4 miles None None None
    East Carolina University - Greenville, North Carolina 448.9 miles George E Hucks 252-744-2391 None
    East Carolina University - Greenville, North Carolina 448.9 miles None None None
    Carilion Clinic Childrens Hospital - Roanoke, Virginia 452.6 miles None None None
    Carilion Clinic Childrens Hospital - Roanoke, Virginia 452.6 miles Mandy M Atkinson 540-981-7376 None
    Duke University Medical Center - Durham, North Carolina 474.7 miles None None None
    UNC Lineberger Comprehensive Cancer Center - Chapel Hill, North Carolina 482.1 miles Stuart H Gold 877-668-0683 cancerclinicaltrials@med.unc.edu
    UNC Lineberger Comprehensive Cancer Center - Chapel Hill, North Carolina 482.1 miles None None None
    West Virginia University Charleston - Charleston, West Virginia 487.0 miles None None None
    Saint John Hospital and Medical Center - Detroit, Michigan 504.8 miles Hadi Sawaf 313-343-3166 None
    Saint John Hospital and Medical Center - Detroit, Michigan 504.8 miles None None None
    Wayne State UniversityKarmanos Cancer Institute - Detroit, Michigan 512.3 miles None None None
    Nationwide Childrens Hospital - Columbus, Ohio 518.1 miles None None None
    Beaumont Childrens HospitalRoyal Oak - Royal Oak, Michigan 519.0 miles Laura K Gowans 248-551-7695 None
    William Beaumont HospitalRoyal Oak - Royal Oak, Michigan 519.0 miles None None None
    Beaumont Childrens HospitalRoyal Oak - Royal Oak, Michigan 519.0 miles None None None
    Wake Forest University Health Sciences - Winston-Salem, North Carolina 523.1 miles None None None
    Wake Forest University Health Sciences - Winston-Salem, North Carolina 523.1 miles Thomas B Russell 336-713-6771 None
    Mercy Childrens Hospital - Toledo, Ohio 534.5 miles None None None
    The Toledo HospitalToledo Childrens Hospital - Toledo, Ohio 538.2 miles Jamie L Dargart 419-824-1842 None
    The Toledo HospitalToledo Childrens Hospital - Toledo, Ohio 538.2 miles None None None
    C S Mott Childrens Hospital - Ann Arbor, Michigan 545.4 miles None None None
    Hurley Medical Center - Flint, Michigan 550.2 miles None None None
    Dayton Childrens Hospital - Dayton, Ohio 582.8 miles None None None
    Dayton Childrens Hospital - Dayton, Ohio 582.8 miles Ayman A ElSheikh 800-237-1225 None
    Novant Health Presbyterian Medical Center - Charlotte, North Carolina 585.2 miles None None None
    Carolinas Medical CenterLevine Cancer Institute - Charlotte, North Carolina 586.6 miles Joel A Kaplan 704-381-9901 joel.kaplan@carolinashealthcare.org
    Carolinas Medical CenterLevine Cancer Institute - Charlotte, North Carolina 586.6 miles None None None
    Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio 611.0 miles None None None
    Cincinnati Childrens Hospital Medical Center - Cincinnati, Ohio 611.0 miles Maureen M OBrien 513-636-3549 maureen.obrien@cchmc.org
    Mission HospitalMemorial Campus - Asheville, North Carolina 637.2 miles None None None
    University of KentuckyMarkey Cancer Center - Lexington, Kentucky 639.4 miles None None None
    Bronson Methodist Hospital - Kalamazoo, Michigan 642.3 miles None None None
    Bronson Methodist Hospital - Kalamazoo, Michigan 642.3 miles Jeffrey S Lobel 800-227-2345 None
    Helen DeVos Childrens Hospital at Spectrum Health - Grand Rapids, Michigan 648.5 miles None None None
    Palmetto Health Richland - Columbia, South Carolina 651.8 miles None None None
    Palmetto Health Richland - Columbia, South Carolina 651.8 miles Ronnie W Neuberg 803-434-3680 None
    BILO Charities Childrens Cancer Center - Greenville, South Carolina 667.6 miles Nichole L Bryant 864-241-6251 None
    BILO Charities Childrens Cancer Center - Greenville, South Carolina 667.6 miles None None None
    Greenville Cancer Treatment Center - Greenville, South Carolina 667.6 miles None None None
    Greenville Cancer Treatment Center - Greenville, South Carolina 667.6 miles Cary E Stroud 864-241-6251 None
    East Tennessee Childrens Hospital - Knoxville, Tennessee 682.9 miles None None None
    East Tennessee Childrens Hospital - Knoxville, Tennessee 682.9 miles Ray C Pais 865-541-8266 None
    Saint Vincent Hospital and Health Care Center - Indianapolis, Indiana 686.2 miles None None None
    Riley Hospital for Children - Indianapolis, Indiana 686.4 miles None None None
    Riley Hospital for Children - Indianapolis, Indiana 686.4 miles Robert J Fallon 888-823-5923 ctsucontact@westat.com
    Medical University of South Carolina - Charleston, South Carolina 691.2 miles None None None
    Medical University of South Carolina - Charleston, South Carolina 691.2 miles Jacqueline M Kraveka 843-792-9321 None
    Kosair Childrens Hospital - Louisville, Kentucky 696.1 miles None None None
    Georgia Regents University Medical Center - Augusta, Georgia 720.1 miles Colleen H McDonough 706-721-1663 cancer@georgiahealth.edu
    Georgia Regents University Medical Center - Augusta, Georgia 720.1 miles None None None
    University of Chicago Comprehensive Cancer Center - Chicago, Illinois 744.7 miles None None None
    Lurie Childrens HospitalChicago - Chicago, Illinois 745.5 miles Elaine R Morgan 773-880-4562 None
    Lurie Childrens HospitalChicago - Chicago, Illinois 745.5 miles None None None
    University of Illinois - Chicago, Illinois 748.9 miles None None None
    University of Illinois - Chicago, Illinois 748.9 miles Mary L Schmidt 312-355-3046 None
    Advocate Childrens HospitalOak Lawn - Oak Lawn, Illinois 752.8 miles Rebecca E McFall 847-723-7570 None
    Advocate Childrens HospitalOak Lawn - Oak Lawn, Illinois 752.8 miles None None None
    Advocate Lutheran General Hospital - Park Ridge, Illinois 756.1 miles None None None
    Advocate Childrens HospitalPark Ridge - Park Ridge, Illinois 756.1 miles None None None
    Advocate Lutheran General Hospital - Park Ridge, Illinois 756.1 miles None None None
    Loyola University Medical Center - Maywood, Illinois 757.2 miles None None None
    Memorial University Medical Center - Savannah, Georgia 769.1 miles None None None
    Midwest Childrens Cancer Center - Milwaukee, Wisconsin 769.3 miles Richard L Tower 414-805-4380 None
    Midwest Childrens Cancer Center - Milwaukee, Wisconsin 769.3 miles None None None
    Saint Vincent Hospital - Green Bay, Wisconsin 781.9 miles John R Hill 920-433-8889 None
    Saint Vincent Hospital - Green Bay, Wisconsin 781.9 miles None None None
    T C Thompson Childrens Hospital - Chattanooga, Tennessee 782.3 miles None None None
    T C Thompson Childrens Hospital - Chattanooga, Tennessee 782.3 miles Manoo G Bhakta 423-778-7289 None
    Childrens Healthcare of Atlanta Egleston - Atlanta, Georgia 795.6 miles Glen Lew 404-785-1112 None
    Childrens Healthcare of Atlanta Egleston - Atlanta, Georgia 795.6 miles None None None
    Vanderbilt UniversityIngram Cancer Center - Nashville, Tennessee 811.9 miles None None None
    University of Wisconsin Hospital and Clinics - Madison, Wisconsin 839.6 miles None None None
    Saint Jude Midwest Affiliate - Peoria, Illinois 854.2 miles Karen S Fernandez 309-655-3258 None
    Saint Jude Midwest Affiliate - Peoria, Illinois 854.2 miles None None None
    Southern Illinois University School of Medicine - Springfield, Illinois 867.7 miles Gregory P Brandt 217-545-7929 None
    Southern Illinois University School of Medicine - Springfield, Illinois 867.7 miles None None None
    Marshfield Clinic - Marshfield, Wisconsin 889.0 miles Michael J McManus 715-389-4457 None
    Marshfield Clinic - Marshfield, Wisconsin 889.0 miles None None None
    Nemours Childrens ClinicJacksonville - Jacksonville, Florida 890.4 miles None None None
    Nemours Childrens ClinicJacksonville - Jacksonville, Florida 890.4 miles Jeffrey H Schwartz 904-697-3529 None
    Childrens Hospital of Alabama - Birmingham, Alabama 915.7 miles Alyssa T Reddy 888-823-5923 ctsucontact@westat.com
    University of Alabama at Birmingham Cancer Center - Birmingham, Alabama 915.7 miles None None None
    Childrens Hospital of Alabama - Birmingham, Alabama 915.7 miles None None None
    Cardinal Glennon Childrens Medical Center - Saint Louis, Missouri 917.7 miles None None None
    Cardinal Glennon Childrens Medical Center - Saint Louis, Missouri 917.7 miles William S Ferguson 314-268-4000 None
    Washington University School of Medicine - Saint Louis, Missouri 919.8 miles None None None
    Washington University School of Medicine - Saint Louis, Missouri 919.8 miles Robert J Hayashi 800-600-3606 info@siteman.wustl.edu
    Mercy Hospital Saint Louis - Saint Louis, Missouri 929.1 miles None None None
    University of IowaHolden Comprehensive Cancer Center - Iowa City, Iowa 948.5 miles Mariko Sato 800-237-1225 None
    University of IowaHolden Comprehensive Cancer Center - Iowa City, Iowa 948.5 miles None None None
    University of Florida - Gainesville, Florida 951.0 miles William B Slayton 352-273-8675 trials@cancer.ufl.edu
    University of Florida - Gainesville, Florida 951.0 miles None None None
    Florida Hospital Orlando - Orlando, Florida 989.4 miles None None None
    Nemours Childrens Clinic Orlando - Orlando, Florida 992.3 miles None None None
    UF Cancer Center at Orlando Health - Orlando, Florida 992.3 miles None None None
    Arnold Palmer Hospital for Children - Orlando, Florida 992.3 miles None None None
    Nemours Childrens Hospital - Orlando, Florida 996.6 miles Jeffrey H Schwartz 904-697-3529 None
    Nemours Childrens Hospital - Orlando, Florida 996.6 miles None None None
    Mayo Clinic - Rochester, Minnesota 997.5 miles None None None
    University of Missouri Ellis Fischel - Columbia, Missouri 1,017.6 miles None None None
    University of Missouri Ellis Fischel - Columbia, Missouri 1,017.6 miles None None None
    Columbia Regional - Columbia, Missouri 1,017.8 miles Thomas W Loew 573-884-4277 loewt@health.missouri.edu
    Columbia Regional - Columbia, Missouri 1,017.8 miles None None None
    University of MinnesotaMasonic Cancer Center - Minneapolis, Minnesota 1,040.9 miles None None None
    University of MinnesotaMasonic Cancer Center - Minneapolis, Minnesota 1,040.9 miles Peter M Gordon 612-624-2620 None
    Childrens Hospitals and Clinics of Minnesota Minneapolis - Minneapolis, Minnesota 1,042.1 miles None None None
    Blank Childrens Hospital - Des Moines, Iowa 1,056.2 miles None None None
    Blank Childrens Hospital - Des Moines, Iowa 1,056.2 miles Wendy L WoodsSwafford 515-241-6729 None
    Saint Josephs HospitalChildrens HospitalTampa - Tampa, Florida 1,057.7 miles Dana A Obzut 800-882-4123 None
    Saint Josephs HospitalChildrens HospitalTampa - Tampa, Florida 1,057.7 miles None None None
    Tampa General Hospital - Tampa, Florida 1,058.1 miles Cameron K Tebbi 800-882-4123 hkourtellis@tgh.org
    Tampa General Hospital - Tampa, Florida 1,058.1 miles None None None
    All Childrens Hospital - Saint Petersburg, Florida 1,073.3 miles Gregory A Hale 727-767-2423 HamblinF@allkids.org
    All Childrens Hospital - Saint Petersburg, Florida 1,073.3 miles None None None
    Saint Marys Hospital - West Palm Beach, Florida 1,074.8 miles Narayana Gowda 888-823-5923 ctsucontact@westat.com
    Saint Marys Hospital - West Palm Beach, Florida 1,074.8 miles None None None
    Nemours Childrens Clinic Pensacola - Pensacola, Florida 1,076.6 miles Jeffrey H Schwartz 904-697-3529 None
    Nemours Childrens Clinic Pensacola - Pensacola, Florida 1,076.6 miles None None None
    University of South Alabama - Mobile, Alabama 1,103.2 miles None None None
    Broward Health Medical Center - Fort Lauderdale, Florida 1,118.6 miles Hector M RodriguezCortes 954-355-5346 None
    Broward Health Medical Center - Fort Lauderdale, Florida 1,118.6 miles None None None
    University of Mississippi Medical Center - Jackson, Mississippi 1,118.9 miles None None None
    University of Mississippi Medical Center - Jackson, Mississippi 1,118.9 miles Gail C Megason 601-815-6700 None
    Lee Memorial Health System - Fort Myers, Florida 1,124.1 miles None None None
    Memorial Regional HospitalJoe DiMaggio Childrens Hospital - Hollywood, Florida 1,125.0 miles Iftikhar Hanif 954-265-2234 None
    Memorial Regional HospitalJoe DiMaggio Childrens Hospital - Hollywood, Florida 1,125.0 miles None None None
    University of Arkansas for Medical Sciences - Little Rock, Arkansas 1,131.5 miles None None None
    Golisano Childrens Hospital of Southwest Florida - Fort Myers, Florida 1,133.3 miles Emad K Salman 239-343-5333 None
    Golisano Childrens Hospital of Southwest Florida - Fort Myers, Florida 1,133.3 miles None None None
    The Childrens Mercy Hospital - Kansas City, Missouri 1,136.3 miles Maxine L Hetherington 816-234-3265 None
    The Childrens Mercy Hospital - Kansas City, Missouri 1,136.3 miles None None None
    University of Miami Miller School of MedicineSylvester Cancer Center - Miami, Florida 1,141.0 miles None None None
    University of Miami Miller School of MedicineSylvester Cancer Center - Miami, Florida 1,141.0 miles None None None
    Nicklaus Childrens Hospital - Miami, Florida 1,146.3 miles None None None
    Baptist Hospital of Miami - Miami, Florida 1,152.7 miles Doured Daghistani 800-599-2456 cancerinfo@baptisthealth.net
    Baptist Hospital of Miami - Miami, Florida 1,152.7 miles None None None
    University of Nebraska Medical Center - Omaha, Nebraska 1,182.2 miles Minnie Abromowitch 402-955-3949 None
    University of Nebraska Medical Center - Omaha, Nebraska 1,182.2 miles None None None
    Childrens Hospital and Medical Center of Omaha - Omaha, Nebraska 1,184.3 miles None None None
    Tulane University Health Sciences Center - New Orleans, Louisiana 1,223.7 miles None None None
    Childrens Hospital New Orleans - New Orleans, Louisiana 1,225.9 miles None None None
    Ochsner Medical Center Jefferson - New Orleans, Louisiana 1,227.0 miles None None None
    Sanford Medical CenterFargo - Fargo, North Dakota 1,230.1 miles None None None
    Sanford Medical CenterFargo - Fargo, North Dakota 1,230.1 miles Samuel O Anim 701-234-6161 None
    Natalie Warren Bryant Cancer Center at Saint Francis - Tulsa, Oklahoma 1,274.3 miles None None None
    University of Oklahoma Health Sciences Center - Oklahoma City, Oklahoma 1,371.2 miles None None None
    University of Oklahoma Health Sciences Center - Oklahoma City, Oklahoma 1,371.2 miles Rene Y McNallKnapp 405-271-4272 julie-traylor@ouhsc.edu
    UT SouthwesternSimmons Cancer CenterDallas - Dallas, Texas 1,414.8 miles Tamra L Slone 214-648-7097 None
    UT SouthwesternSimmons Cancer CenterDallas - Dallas, Texas 1,414.8 miles None None None
    Medical City Dallas Hospital - Dallas, Texas 1,417.3 miles None None None
    Cook Childrens Medical Center - Fort Worth, Texas 1,449.7 miles None None None
    M D Anderson Cancer Center - Houston, Texas 1,475.7 miles None None None
    Baylor College of Medicine - Houston, Texas 1,475.7 miles Timothy C Griffin 713-798-1354 burton@bcm.edu
    Baylor College of Medicine - Houston, Texas 1,475.7 miles None None None
    Scott and White Memorial Hospital - Temple, Texas 1,513.0 miles Guy H Grayson 254-724-5407 None
    Scott and White Memorial Hospital - Temple, Texas 1,513.0 miles None None None
    Dell Childrens Medical Center of Central Texas - Austin, Texas 1,559.8 miles None None None
    Texas Tech University Health Science CenterAmarillo - Amarillo, Texas 1,605.8 miles None None None
    Texas Tech University Health Science CenterAmarillo - Amarillo, Texas 1,605.8 miles None None None
    Methodist Childrens Hospital of South Texas - San Antonio, Texas 1,635.9 miles None None None
    University of Texas Health Science Center at San Antonio - San Antonio, Texas 1,635.9 miles None None None
    Childrens Hospital of San Antonio - San Antonio, Texas 1,636.8 miles Timothy C Griffin 713-798-1354 burton@bcm.edu
    Childrens Hospital of San Antonio - San Antonio, Texas 1,636.8 miles None None None
    Covenant Childrens Hospital - Lubbock, Texas 1,654.2 miles None None None
    Covenant Childrens Hospital - Lubbock, Texas 1,654.2 miles Latha Prasannan 806-725-8000 jaccresearch@covhs.org
    Driscoll Childrens Hospital - Corpus Christi, Texas 1,655.7 miles None None None
    Driscoll Childrens Hospital - Corpus Christi, Texas 1,655.7 miles M C Johnson 361-694-5311 None
    Childrens Hospital Colorado - Aurora, Colorado 1,658.2 miles Kelly W Maloney 720-777-6672 None
    Childrens Hospital Colorado - Aurora, Colorado 1,658.2 miles None None None
    Rocky Mountain Hospital for ChildrenPresbyterian Saint Lukes Medical Center - Denver, Colorado 1,665.3 miles Jennifer J Clark 866-775-6246 None
    Rocky Mountain Hospital for ChildrenPresbyterian Saint Lukes Medical Center - Denver, Colorado 1,665.3 miles None None None
    Vannie Cook Childrens Clinic - McAllen, Texas 1,767.1 miles None None None
    University of New Mexico Cancer Center - Albuquerque, New Mexico 1,854.7 miles Koh B Boayue 505-272-6972 None
    University of New Mexico Cancer Center - Albuquerque, New Mexico 1,854.7 miles None None None
    University of New Mexico Cancer Center - Albuquerque, New Mexico 1,856.4 miles None None None
    University of New Mexico Cancer Center - Albuquerque, New Mexico 1,856.4 miles Michael J Burke 414-955-4198 mmburke@mcw.edu
    El Paso Childrens Hospital - El Paso, Texas 1,946.0 miles None None None
    El Paso Childrens Hospital - El Paso, Texas 1,946.0 miles Lisa L Hartman 888-823-5923 ctsucontact@westat.com
    Primary Childrens Hospital - Salt Lake City, Utah 2,000.4 miles None None None
    Primary Childrens Hospital - Salt Lake City, Utah 2,000.4 miles Phillip E Barnette 801-585-5270 None
    The University of Arizona Medical CenterUniversity Campus - Tucson, Arizona 2,164.2 miles None None None
    Saint Lukes Mountain States Tumor Institute - Boise, Idaho 2,176.6 miles None None None
    Cardon Childrens Medical Center - Mesa, Arizona 2,176.9 miles Xiaxin Li 602-747-9738 None
    Cardon Childrens Medical Center - Mesa, Arizona 2,176.9 miles None None None
    Phoenix Childrens Hospital - Phoenix, Arizona 2,181.7 miles None None None
    Providence Sacred Heart Medical Center and Childrens Hospital - Spokane, Washington 2,201.6 miles None None None
    Nevada Cancer Research Foundation CCOP - Las Vegas, Nevada 2,270.3 miles Jonathan Bernstein 702-384-0013 None
    Nevada Cancer Research Foundation CCOP - Las Vegas, Nevada 2,270.3 miles None None None
    Childrens Specialty Center of Nevada II - Las Vegas, Nevada 2,271.0 miles Jonathan Bernstein 702-384-0013 None
    Childrens Specialty Center of Nevada II - Las Vegas, Nevada 2,271.0 miles None None None
    Sunrise Hospital and Medical Center - Las Vegas, Nevada 2,271.0 miles None None None
    University Medical Center of Southern Nevada - Las Vegas, Nevada 2,272.6 miles None None None
    Summerlin Hospital Medical Center - Las Vegas, Nevada 2,278.7 miles None None None
    Seattle Childrens Hospital - Seattle, Washington 2,424.5 miles None None None
    Mary Bridge Childrens Hospital and Health Center - Tacoma, Washington 2,436.7 miles None None None
    Loma Linda University Medical Center - Loma Linda, California 2,437.5 miles Antranik A Bedros 909-558-3375 None
    Loma Linda University Medical Center - Loma Linda, California 2,437.5 miles None None None
    Madigan Army Medical Center - Tacoma, Washington 2,442.6 miles None None None
    Legacy Emanuel Childrens Hospital - Portland, Oregon 2,466.8 miles None None None
    Oregon Health and Science University - Portland, Oregon 2,468.2 miles None None None
    Oregon Health and Science University - Portland, Oregon 2,468.2 miles Bill H Chang 503-494-1080 trials@ohsu.edu
    Rady Childrens Hospital San Diego - San Diego, California 2,469.3 miles None None None
    Rady Childrens Hospital San Diego - San Diego, California 2,469.3 miles William D Roberts 858-966-5934 None
    City of Hope Comprehensive Cancer Center - Duarte, California 2,472.0 miles None None None
    Naval Medical Center San Diego - San Diego, California 2,472.1 miles Shelton A Viola 619-532-8712 None
    Naval Medical Center San Diego - San Diego, California 2,472.1 miles None None None
    Childrens Hospital of Orange County - Orange, California 2,477.9 miles Violet Shen 714-997-3000 None
    Childrens Hospital of Orange County - Orange, California 2,477.9 miles None None None
    Southern California Permanente Medical Group - Downey, California 2,487.8 miles None None None
    Southern California Permanente Medical Group - Downey, California 2,487.8 miles Robert M Cooper 626-564-3455 None
    Childrens Hospital Los Angeles - Los Angeles, California 2,489.4 miles None None None
    Miller Childrens and Womens Hospital Long Beach - Long Beach, California 2,493.3 miles None None None
    CedarsSinai Medical Center - Los Angeles, California 2,495.4 miles None None None
    Los Angeles Biomedical Research Institute at HarborUCLA Medical Center - Torrance, California 2,498.1 miles Joseph L Lasky 888-662-8252 None
    Los Angeles Biomedical Research Institute at HarborUCLA Medical Center - Torrance, California 2,498.1 miles None None None
    Mattel Childrens Hospital UCLA - Los Angeles, California 2,499.3 miles None None None
    Mattel Childrens Hospital UCLA - Los Angeles, California 2,499.3 miles Theodore B Moore 562-933-7802 tmoore3@memorialcare.org
    Sutter General Hospital - Sacramento, California 2,536.1 miles None None None
    University of California Davis Comprehensive Cancer Center - Sacramento, California 2,536.2 miles None None None
    Santa Barbara Cottage Hospital - Santa Barbara, California 2,554.6 miles None None None
    Kaiser PermanenteOakland - Oakland, California 2,592.6 miles Steven K Bergstrom 626-564-3455 None
    Kaiser PermanenteOakland - Oakland, California 2,592.6 miles None None None
    Lucile Packard Childrens Hospital Stanford University - Palo Alto, California 2,600.0 miles Neyssa M Marina 650-498-7061 clinicaltrials@med.stanford.edu
    Lucile Packard Childrens Hospital Stanford University - Palo Alto, California 2,600.0 miles None None None
    UCSF Medical CenterMission Bay - San Francisco, California 2,603.0 miles None None None
    UCSF Medical CenterParnassus - San Francisco, California 2,606.4 miles None None None
    UCSF Medical CenterParnassus - San Francisco, California 2,606.4 miles None None None
    Providence Alaska Medical Center - Anchorage, Alaska 3,365.1 miles None None None
    Tripler Army Medical Center - Honolulu, Hawaii 5,000.9 miles None None None
    Kapiolani Medical Center for Women and Children - Honolulu, Hawaii 5,002.3 miles None None None
    University of Hawaii Cancer Center - Honolulu, Hawaii 5,002.7 miles None None None

    ClinicalTrialsLocator.com provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from ClinicalTrials.gov. This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.