Predicting Successful Sleep Apnea Treatment With Acetazolamide in Heart Failure Patients


The ultimate goal is to improve our understanding of the pathophysiology and resistance to effective treatment of sleep disordered breathing in patients with heart failure, with a focus on selecting patients that will benefit specifically from acetazolamide treatment. The study addresses three primary hypotheses: 1) Acetazolamide treatment will reduce the apnea-hypopnea index and improve markers of heart-failure severity in heart-failure patients with sleep apnea. 2) Acetazolamide will provide the greatest improvement in patients with the least severe ventilatory control instability (lowest loop gain). 3) Acetazolamide will act primarily via stabilizing ventilatory control (reducing loop gain), rather than via improvement to upper airway anatomy, pulmonary congestion, and cardiac function.

Study Start Date

August 2011

Estimated Completion Date

July 2016


  • Drug: Acetazolamide
  • Drug: Placebo


  • Cardiology: Heart Failure
  • Internal Medicine: Cardiology,Clinical Pharmacology,Pulmonology
  • Pulmonology: Apnea/Sleep Disorders,Clinical Pharmacology
  • Pharmacy: Drug Trials

MeSH Terms

  • Acetazolamide
  • Heart Failure
  • Sleep Apnea Syndromes

Study ID

Brigham and Women's Hospital -- 2011-P-000049/1



Trial ID


Study Type


Trial Phase


Enrollment Quota



Brigham and Women's Hospital

Inclusion Criteria

  • LVEF<50%
  • Age 18-80

Exclusion Criteria

  • severe obstructive respiratory disease
  • unstable heart failure status
  • recent use of positive airway pressure therapy
  • current use of medications known to affect ventilation
  • severe kidney disease
  • hemoglobin <9.5g/dl (moderate-severe anemia)




18 Years to 80 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles Scott A Sands PhD None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.